Driven equilibrium magnetic resonance imaging of articular cartilage: Initial clinical experience

Gold, Garry E.; Fuller, Samuel E.; Hargreaves, Brian A.; Stevens, Kathryn J.; Beaulieu, Christopher F.

doi:10.1002/jmri.20276

Cited by 74 publications

(46 citation statements)

References 19 publications

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“…Yoshioka et al used this sequence in 35 osteoarthritic knees and correlated the imaging findings with arthroscopy; in their study, the fatsuppressed three-dimensional DEFT images showed results similar to SPGR and PD-w FSE sequences with high sensitivities yet relatively low specificities [16]. Gold et al compared 3D-DEFT and T2-FSE sequences in 104 consecutive patients with knee pain and used arthroscopy in 24 patients as a standard of reference [28]. These investigators found that the 3D-DEFT sequences provided excellent synovial fluid-to-cartilage contrast while preserving signal from cartilage, giving this method a high cartilage SNR.…”

Section: What Field Strength Should Be Used To Image Cartilage?mentioning

confidence: 99%

Cartilage imaging: motivation, techniques, current and future significance

2006

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Cartilage repair techniques and pharmacological therapies are currently areas of major clinical interest and research, in particular to prevent and treat osteoarthritis. MR imaging-based techniques to visualize cartilage are prerequisites to guide and monitor these therapies. In this review article, standard MR imaging sequences are described, including proton density-weighted fast spin echo, spoiled gradient echo and dual echo steady state sequences. In addition, new sequences that have been developed and are currently being investigated are presented, including driven equilibrium Fourier transform and steady-state free precession-based imaging. Using high-field MR imaging at 3.0-T, visualization of cartilage and the related pathology has been improved. Volumetric quantitative cartilage MR imaging was developed as a tool to monitor the progression of osteoarthritis and to evaluate new pharmacological cartilage protective therapies. The most exciting developments, however, are in the field of cartilage matrix assessment with quantitative dGEMRIC, T2 and T1rho mapping techniques. These techniques aim at detecting cartilage damage at a stage when changes are potentially still reversible, before cartilage tissue is lost. There is currently substantial interest in these techniques from rheumatologists and orthopedists; radiologists therefore need to keep up with these developments.

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Section: What Field Strength Should Be Used To Image Cartilage?mentioning

confidence: 99%

Cartilage imaging: motivation, techniques, current and future significance

2006

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“…Three-dimensional imaging sequences of the knee have been tested and previously evaluated [6][7][8][9][10][11], but most of these were gradient echo sequences, and given different image contrast had limitations in replacing 2D T2-or IM FSE sequences for evaluating internal knee derangements.…”

Section: Introductionmentioning

confidence: 99%

Isotropic 3D fast spin-echo imaging versus standard 2D imaging at 3.0 T of the knee—image quality and diagnostic performance

et al. 2009

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Isotropic 3D fast spin-echo imaging versus standard 2D imaging at 3.0 T of the knee-image quality and diagnostic performance Abstract The objective of this study was to compare a newly developed fat-saturated intermediate-weighted (IM-w) 3D fast spin-echo (FSE) sequence with standard 2D IM-w FSE sequences regarding image quality and diagnostic performance in assessing abnormal findings of the knee. MR imaging was performed at 3.0 T in 50 patients. Images were assessed independently by three radiologists. Image quality was rated significantly higher (p<0.05) for the 2D versus the 3D FSE sequences. Sensitivity for cartilage lesions was slightly higher for the 3D sequence, but specificity was lower. Low contrast objects were better visualized with 2D sequences, while high contrast objects were better shown with the 3D sequence. Confidence scores were higher for 2D than for 3D sequences, but differences were not significant. In conclusion, isotropic 3D FSE IM-w imaging may enhance standard knee MRI by increased visualization of high contrast lesions; however, 3D FSE image quality was lower.

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“…The main limitation of current MR protocols for evaluating the articular cartilage of the knee joint is their inability to identify early cartilage degeneration and superficial posttraumatic cartilage defects, which may progress to more advanced osteoarthritis (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The low sensitivity of these protocols is primarily attributed to suboptimal spatial resolution (19).…”

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confidence: 99%