Purpose The research explores the shift to Quality 4.0, examining the move towards a data-focussed transformation within organizational frameworks. This transition is characterized by incorporating Industry 4.0 technological innovations into existing quality management frameworks, signifying a significant evolution in quality control systems. Despite the evident advantages, the practical deployment in the Indian manufacturing sector encounters various obstacles. This research is dedicated to a thorough examination of these impediments. It is structured around a set of pivotal research questions: First, it seeks to identify the key barriers that impede the adoption of Quality 4.0. Second, it aims to elucidate these barriers' interrelations and mutual dependencies. Thirdly, the research prioritizes these barriers in terms of their significance to the adoption process. Finally, it contemplates the ramifications of these priorities for the strategic advancement of manufacturing practices and the development of informed policies. By answering these questions, the research provides a detailed understanding of the challenges faced. It offers actionable insights for practitioners and policymakers implementing Quality 4.0 in the Indian manufacturing sector.Design/methodology/approach Employing Interpretive Structural Modelling and Matrix Impact of Cross Multiplication Applied to Classification, the authors probe the interdependencies amongst fourteen identified barriers inhibiting Quality 4.0 adoption. These barriers were categorized according to their driving power and dependence, providing a richer understanding of the dynamic obstacles within the Technology–Organization–Environment (TOE) framework.Findings The study results highlight the lack of Quality 4.0 standards and Big Data Analytics (BDA) tools as fundamental obstacles to integrating Quality 4.0 within the Indian manufacturing sector. Additionally, the study results contravene dominant academic narratives, suggesting that the cumulative impact of organizational barriers is marginal, contrary to theoretical postulations emphasizing their central significance in Quality 4.0 assimilation.Practical implications This research provides concrete strategies, such as developing a collaborative platform for sharing best practices in Quality 4.0 standards, which fosters a synergistic relationship between organizations and policymakers, for instance, by creating a joint task force, comprised of industry leaders and regulatory bodies, dedicated to formulating and disseminating comprehensive guidelines for Quality 4.0 adoption. This initiative could lead to establishing industry-wide standards, benefiting from the pooled expertise of diverse stakeholders. Additionally, the study underscores the necessity for robust, standardized Big Data Analytics tools specifically designed to meet the Quality 4.0 criteria, which can be developed through public-private partnerships. These tools would facilitate the seamless integration of Quality 4.0 processes, demonstrating a direct route for overcoming the barriers of inadequate standards.Originality/value This research delineates specific obstacles to Quality 4.0 adoption by applying the TOE framework, detailing how these barriers interact with and influence each other, particularly highlighting the previously overlooked environmental factors. The analysis reveals a critical interdependence between “lack of standards for Quality 4.0” and “lack of standardized BDA tools and solutions,” providing nuanced insights into their conjoined effect on stalling progress in this field. Moreover, the study contributes to the theoretical body of knowledge by mapping out these novel impediments, offering a more comprehensive understanding of the challenges faced in adopting Quality 4.0.