Drop-on-demand printing of personalised orodispersible films fabricated by precision micro-dispensing

Tam, Chak Hin; Alexander, Matthew S.; Belton, Peter; Qi, Sheng

doi:10.1016/j.ijpharm.2021.121279

Cited by 14 publications

(2 citation statements)

References 41 publications

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“…Polymer-Based Pharma-Inks: In polymer-based pharma-inks, a single or multiple polymers from synthetic or natural sources is used for the formulation of the ink. Synthetic polymers, such as polyvinylpyrrolidone (PVP), [6,87] polyethylene glycol (PEG), [88] polyvinyl alcohol (PVA), [89] poly(lactic-co-glycolic acid) (PLGA), [87] and semisynthetic polymers, such as methyl cellulose (MC), ethyl cellulose (EC) hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), microcrystalline cellulose (MCC), and hydroxypropyl methylcellulose (HPMC), [90] are instrumental in improving the viscosity and surface tension of the ink, preventing nozzle clogging, and ensuring the consistent formation of droplets during the printing process. These polymers also play a critical role in controlling drug release, enabling the development of dosage forms with precisely regulated drug release profiles.…”

Section: Content-based Classificationmentioning

confidence: 99%

Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

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Section: Content-based Classificationmentioning

confidence: 99%

Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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“…3D printing) has been attracting attention due to its high flexibility and cost-effectiveness. Currently, additive manufacturing methods are widely used in manufacturing personalized products such as medical implants [8].…”

Section: Introductionmentioning

confidence: 99%

Personalized Product Design Through Digital Fabrication

Minnoye

Tajdari

Doubrovski

et al. 2022

Volume 2: 42nd Computers and Information in Engineering Conference (CIE)

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Personalized designs bring added value to the products and the users. Meanwhile, they also pose challenges to the product design process as each product differs. In this paper, with the focus on personalized fit, we present an overview as well as details of the personalized design process based on design practice. The general workflow of personalized product design is introduced first. Then different steps in the workflow such as human data/parameters acquisition, computational design, design for digital fabrication, and product evaluation are presented. Tools and methods that are often used in different steps in the process are also outlined where in human data acquisition, 3D scanning, and digital human models are addressed. For computational design, the use of computational thinking tools such as abstraction, decomposition, pattern recognition and algorithms are discussed. In design for digital fabrication, additive manufacturing methods (e.g. FDM), and their requirements on the design are highlighted. For product evaluation, both functional evaluation and usability evaluation are considered and the evaluation results can be the starting point of the next design iteration. Finally, several case studies are presented for a better understanding of the workflow, the importance of different steps in the workflow and the deviations in the approach regarding different contexts. In conclusion, we intend to provide designers a holistic view of the design process in designing personalized products as well as help practitioners trigger innovations regarding each step of the process.

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