Drop size distribution in highly concentrated liquid–liquid dispersions using a light back scattering method

Lovick, J; Mouza, A.A.; Paras, S.V.; Lye, Gary J.; Angeli, Panagiota

doi:10.1002/jctb.1205

Cited by 65 publications

(55 citation statements)

References 30 publications

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“…12 This is because for a particle size less than 20 μm, the light backscattering instruments may receive backscattered light instead of reflected light from particles which tends to oversize the particles. 29 The ORM was used successfully in analyzing system changes such as a change of drop size distributions (DSD) at different power inputs.…”

Section: Methods Of Measurementmentioning

confidence: 99%

“…11 Existing data on drop size and distributions are limited for unstable dispersions and highly dispersed phase fractions caused by the difficulty of performing measurements under such conditions. 12 Available measurement techniques such as image analysis techniques are not suitable at high concentration because there is a tendency of drop overlapping in the images 13 and fast acting equipment are required to capture rapid changes in unstable dispersions. In this work, the suitability and limitations of laser systems and image analysis techniques on drop size measurements are focused.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Review on Measurement Techniques for Drop Size Distribution in a Stirred Vessel

Abidin

Raman

Nor

2013

Ind. Eng. Chem. Res.

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A literature review on measurements of drop size distribution in liquid−liquid dispersion produced in a stirred vessel is presented in this work. The methods of measurement can be classified into in situ and external measurement. Two main groups of measurement techniques, namely, a laser system and image analysis, are reviewed. Several issues regarding the applications of the techniques and possible ways to overcome the problems are discussed. The suitability of different techniques depends on the operating conditions and properties of the drops. Laser systems provide fast in situ measurements which are useful for online monitoring and detecting process changes but unable to deliver reliable drop size and distribution values. In situ image analysis techniques could give accurate measurement of drop size, but a long time is required to analyze drops from a large number of images. However with development of automated image analysis, analysis time can be reduced. Therefore real-time monitoring and process control by image analysis techniques can be possible.

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Section: Methods Of Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review on Measurement Techniques for Drop Size Distribution in a Stirred Vessel

Abidin

Raman

Nor

2013

Ind. Eng. Chem. Res.

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“…Two acrylic columns having internal diameters of 25 and 140 mm are used. A rigid borescope [22][23][24][25][26][27][28][29][30][31] (Olympus) with a 60 o field of view and 0 o direction of view is used to obtain particle images in a dynamic system. The borescope has a diameter of 6 mm and length of 250 mm.…”

Section: Methodsmentioning

confidence: 99%

Determination of Actual Object Size Distribution from Direct Imaging

Hossain¹,

Chen²,

Yang³

et al. 2009

Ind. Eng. Chem. Res.

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Direct imaging is a technique commonly used in the study of particle, bubble, and droplet size distribution in a dynamic system. Objects such as particles, bubbles, and droplets can be present at various distances from the imaging device when images are captured. Hence, the location of the object will need to be known in order to determine the actual size of an individual object. However, the location of the object cannot be determined from a single image. A single calibration scale defined at the focusing plane is normally used for the determination of all the object sizes from images. When the focus is close to the imaging device, the change in magnification with location is large. The size distribution obtained from the use of a single calibration scale would thus give a considerable deviation from the actual size distribution. In this study, a statistical method is proposed to reconstruct the actual object size distribution from the experimental object size distribution obtained from images using a single calibration scale defined at the focusing plane. Experiments are performed to validate the accuracy of the proposed method on the particle size distribution determination in a settling system. The stability of the proposed method is also analyzed theoretically for imaging devices with different depth-of-field (DOF), focusing location, and change in magnification with distance.

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“…Galindo et al (2000) operating with a 15% (v/v) oil-aqueous system at 250 rpm reported mean droplet size in non-aerated conditions of roughly 100 mm. Lovick et al (2005) in a 40% (v/v) oil-aqueous system at 350 rpm obtained droplets with a diameter of about 45 mm.…”

Section: Two-phase Aqueous-organic Systemmentioning

confidence: 99%

Scaling‐up of complex whole‐cell bioconversions in conventional and non‐conventional media

Marques

Carvalho

Fernandes

2010

Biotech & Bioengineering

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The use of whole cells is becoming a more common approach in pharmaceutical and agrochemical industries in order to obtain pure compounds with fewer production steps, higher yields, and cleaner processes, as compared to those achieved with traditional strategies. Whole cells are often used as enzymes pools, in particular when multi-step reactions and/or co-factor regeneration are envisaged. Nonetheless, published information on the scale-up of such systems both in aqueous and in two-phase aqueous-organic systems is relatively scarce. The present work aims to evaluate suitable scale-up criteria in conventional and non-conventional medium for a whole-cell bioconversion that uses resting cells of Mycobacterium sp. NRRL B-3805 to cleave the side chain of beta-sitosterol, a poorly water-soluble substrate. The experiments were performed in 24-well microtiter plates and in 250 mL shaken flasks as orbital stirred systems, and in 300 mL stirred tanks as mechanically stirred systems. Results show that productivity yields were similar in all scales tested, when maintaining oxygen mass transfer coefficients constant in aqueous systems, or when maintaining constant volumetric power consumption in aqueous-organic two-phase systems.

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Drop size distribution in highly concentrated liquid–liquid dispersions using a light back scattering method

Cited by 65 publications

References 30 publications

Review on Measurement Techniques for Drop Size Distribution in a Stirred Vessel

Review on Measurement Techniques for Drop Size Distribution in a Stirred Vessel

Determination of Actual Object Size Distribution from Direct Imaging

Scaling‐up of complex whole‐cell bioconversions in conventional and non‐conventional media

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