Dropout is a global and complex phenomenon affecting all universities. This study aimed at investigating the intrinsic and extrinsic factors causing dropout at the Open University of Mauritius (OU). Secondary data about 1885 learners were collected for five intakes and three levels of study - foundation, undergraduate and Master courses. The dropout rates were 46.08%, 39.14% and 17.31% respectively, showing that those with previous tertiary education were less likely to drop out of studies. Analysis of data from 96 completed questionnaires revealed that female learners were more persistent in their studies while mature students were less likely to drop out from university. Personal and career-related issues were the major causes leading to attrition at OU. Sub causes included wrong choice in programmes, inadequate tutorial support and lack of employer’s support. Corrective actions suggested include providing counselling sessions before registration and during studies, implementing strategies to help students develop time management skills, developing courses in line with industry requirements and improving tutor’s support. The low attrition rate at OU is probably because most of its learners are working adults who are able to shoulder learning with greater responsibility. This is also because OU has maximised on technology to reach out to learners, hence mitigating isolation.