Drops in the cell ocean: new roles for non-coding RNAs in liquid–liquid phase separation

Li, Mingyue; Thorne, Rick F.; Zhang, Xu Dong; Wu, Mian; Chen, Song

doi:10.1007/s42764-022-00091-0

GENOME INSTAB. DIS.

2022

DOI: 10.1007/s42764-022-00091-0

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Drops in the cell ocean: new roles for non-coding RNAs in liquid–liquid phase separation

Mingyue Li

Rick F. Thorne

Xu Dong Zhang

et al.

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Cited by 3 publications

References 154 publications

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Pericentromeric satellite RNAs as flexible protein partners in the regulation of nuclear structure

Lopes,

Louzada,

Gama‐Carvalho

et al. 2024

WIREs RNA

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Pericentromeric heterochromatin is mainly composed of satellite DNA sequences. Although being historically associated with transcriptional repression, some pericentromeric satellite DNA sequences are transcribed. The transcription events of pericentromeric satellite sequences occur in highly flexible biological contexts. Hence, the apparent randomness of pericentromeric satellite transcription incites the discussion about the attribution of biological functions. However, pericentromeric satellite RNAs have clear roles in the organization of nuclear structure. Silencing pericentromeric heterochromatin depends on pericentromeric satellite RNAs, that, in a feedback mechanism, contribute to the repression of pericentromeric heterochromatin. Moreover, pericentromeric satellite RNAs can also act as scaffolding molecules in condensate subnuclear structures (e.g., nuclear stress bodies). Since the formation/dissociation of nuclear condensates provides cell adaptability, pericentromeric satellite RNAs can be an epigenetic platform for regulating (sub)nuclear structure. We review current knowledge about pericentromeric satellite RNAs that, irrespective of the meaning of biological function, should be functionally addressed in regular and disease settings.This article is categorized under: RNA Methods > RNA Analyses in Cells RNA in Disease and Development > RNA in Disease

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Pericentromeric satellite RNAs as flexible protein partners in the regulation of nuclear structure

Lopes,

Louzada,

Gama‐Carvalho

et al. 2024

WIREs RNA

View full text Add to dashboard Cite

show abstract

The role of long noncoding RNAs in liquid–liquid phase separation

Zhang

et al. 2023

Cellular Signalling

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Reciprocal interactions between lncRNAs and MYC in colorectal cancer: partners in crime

Lei,

Zhu,

Yao

et al. 2024

Cell Death Dis

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Proto-oncogenic MYC is frequently dysregulated in colorectal cancer (CRC). In the past decades, long noncoding RNAs (lncRNAs) have emerged as important regulators in cancers, acting as scaffolds, molecular decoys, post-transcriptional regulators, and others. Interestingly, lncRNAs are able to control MYC expression both at transcriptional and post-transcriptional levels. It is suggested that the reciprocal interaction of MYC and lncRNAs often occurs in CRC. MYC can affect the cell fate by promoting or inhibiting the transcription of some lncRNAs. At the same time, some lncRNAs can also affect MYC expression or transcriptional activity, and in turn decide the cell fate. In this review we summarized the current knowledge about the MYC and lncRNA axis, focusing on its mutual regulation, roles in CRC, and proposed potential therapeutic prospects for CRC treatment.

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Drops in the cell ocean: new roles for non-coding RNAs in liquid–liquid phase separation

Cited by 3 publications

References 154 publications

Pericentromeric satellite RNAs as flexible protein partners in the regulation of nuclear structure

Pericentromeric satellite RNAs as flexible protein partners in the regulation of nuclear structure

The role of long noncoding RNAs in liquid–liquid phase separation

Reciprocal interactions between lncRNAs and MYC in colorectal cancer: partners in crime

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