Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development

Wang, Xiao Chun; Liu, Ziguang; Jin, Li

doi:10.1007/s10495-019-01527-x

Cited by 5 publications

(1 citation statement)

References 58 publications

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“…As JNK signaling plays signi cant roles in regulating apoptotic cell death [42][43][44][45], dSTK10 depletiontriggered developmental apoptosis may depend on JNK pathway activation. In agreement with this assumption, knockdown of dSTK10, but not lacZ, by ptc-Gal4 resulted in upregulated expression of TRE-RFP (Fig.…”

Section: Depletion Of Dstk10 Promotes Jnk Pathway Activationmentioning

confidence: 99%

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosis

Sun

Zhu

et al. 2023

Preprint

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Background The c-Jun N-terminal kinase (JNK) pathway is an evolutionarily conserved regulator of cell death, which is essential for coordinating tissue homeostasis. In this study, we have characterized the Drosophila Ste20-like kinase dSTK10 as a novel modulator of JNK pathway-mediated apoptotic cell death. Results First, ectopic JNK signaling-triggered cell death is enhanced in heterozygous dSTK10 mutants, and suppressed by dSTK10 overexpression. Second, depletion of dSTK10 activates JNK signaling, which results in enhanced apoptosis and impaired tissue homeostasis. In addition, genetic epistasis analysis suggests that dSTK10 acts upstream of or in parallel to Hep to regulate JNK-mediated apoptotic cell death. Moreover, dSTK10 is necessary and sufficient for preventing physiologic JNK signaling-mediated cell death in development. Furthermore, introduction of STK10, the human ortholog of dSTK10, into Drosophila restores dSTK10 depletion-induced cell death and compromised tissue homeostasis. Lastly, knockdown of STK10 in human cancer cells also leads to JNK activation. Conclusions Thus, this study has uncovered an evolutionarily conserved role of dSTK10/STK10 in blocking JNK signaling, which is required for cell death inhibition and tissue homeostasis maintenance in Drosophila development.

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Section: Depletion Of Dstk10 Promotes Jnk Pathway Activationmentioning

confidence: 99%

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosis

Sun

Zhu

et al. 2023

Preprint

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show abstract

Effects of cadmium on osteoblast cell line: Exportin 1 accumulation, p-JNK activation, DNA damage and cell apoptosis

Wang

et al. 2021

Ecotoxicology and Environmental Safety

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Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis

Li,

Zhu,

Sun

et al. 2023

Cell Div

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Background The c-Jun N-terminal kinase (JNK) pathway is an evolutionarily conserved regulator of cell death, which is essential for coordinating tissue homeostasis. In this study, we have characterized the Drosophila Ste20-like kinase Slik as a novel modulator of JNK pathway-mediated apoptotic cell death. Results First, ectopic JNK signaling-triggered cell death is enhanced by slik depletion whereas suppressed by Slik overexpression. Second, loss of slik activates JNK signaling, which results in enhanced apoptosis and impaired tissue homeostasis. In addition, genetic epistasis analysis suggests that Slik acts upstream of or in parallel to Hep to regulate JNK-mediated apoptotic cell death. Moreover, Slik is necessary and sufficient for preventing physiologic JNK signaling-mediated cell death in development. Furthermore, introduction of STK10, the human ortholog of Slik, into Drosophila restores slik depletion-induced cell death and compromised tissue homeostasis. Lastly, knockdown of STK10 in human cancer cells also leads to JNK activation, which is cancelled by expression of Slik. Conclusions This study has uncovered an evolutionarily conserved role of Slik/STK10 in blocking JNK signaling, which is required for cell death inhibition and tissue homeostasis maintenance in development.

show abstract

Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development

Cited by 5 publications

References 58 publications

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosis

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosis

Effects of cadmium on osteoblast cell line: Exportin 1 accumulation, p-JNK activation, DNA damage and cell apoptosis

Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis

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