2005
DOI: 10.1016/j.mrgentox.2005.02.002
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Drosophila wing-spot test for genotoxic assessment of pollutants in water samples from urban and industrial origin

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Cited by 16 publications
(8 citation statements)
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“…The lack of clear differences in the genotoxicity of samples from Sites 1 and 2 may be due to resuspension or trophic transference of particle-bound mutagens that are reintroduced into the water column. Similar results were obtained by Amaral et al [2005], who observed genotoxicity in surface waters collected from the Caí River (Rio Grande do Sul, Brazil), which is impacted by untreated urban discharges. Although mitotic recombination was involved in these responses, the genotoxicity of these samples was partially due to mutational events.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…The lack of clear differences in the genotoxicity of samples from Sites 1 and 2 may be due to resuspension or trophic transference of particle-bound mutagens that are reintroduced into the water column. Similar results were obtained by Amaral et al [2005], who observed genotoxicity in surface waters collected from the Caí River (Rio Grande do Sul, Brazil), which is impacted by untreated urban discharges. Although mitotic recombination was involved in these responses, the genotoxicity of these samples was partially due to mutational events.…”
Section: Discussionsupporting
confidence: 88%
“…Because of the broad spectrum of genetic end points that can be monitored, the somatic genotoxicity assays in Drosophila are considered excellent candidates for monitoring the genotoxicity of environmental contaminants [Graf et al, 1996]. They have proven to be highly sensitive for the detection of environmental genotoxic agents in airborne particulate matter, especially PAHs [Graf and Singer, 1989;Delgado-Rodriguez et al, 1995, and in aquatic environments, showing sufficient sensitivity to evaluate the impact of environmental contaminants present in unprocessed water samples [Amaral et al, 2005[Amaral et al, , 2006.…”
Section: Introductionmentioning
confidence: 99%
“…Fish sampling was carried out in March 2003, and water samples were collected at the same time according to Vargas et al [1993] and Amaral et al [2005]. Analyses for pH, dissolved oxygen (DO), and metal content performed on these samples are shown in Table I.…”
Section: Collection Sites and Samplingmentioning
confidence: 99%
“…It has been touted as a high throughput screening method by virtue that it is a single generation test requiring minimal handling of flies. The SMART test continues to be used extensively in assays of compounds and mixtures ranging from polycyclic aromatic hydrocarbons (PAHs) to polluted river water [30]. Yet, the SMART assay has limitations with respect to the requirements of HTS needed for chemical libraries of today due to the materials and time needed to treat and culture larvae and subsequently determine adult wing spot frequency.…”
Section: Examples Of Measurable Endpoints In Drosophila Toxicologymentioning
confidence: 99%