Drotaverine hydrochloride for augmentation of labor

Singh, Kanwardeep; Jain, Pragya; Goel, Neerja; Saxena, Ashok Kumar

doi:10.1016/s0020-7292(03)00276-5

Cited by 53 publications

(52 citation statements)

References 4 publications

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“…Regarding the duration of 3 rd stage of labor in the present study, the mean time was shorter in HBB group. This result is near to the study done by Singh KC et al (2004) which showed that the mean time of 3 rd stage of labor was about 9.33minutes 13 . C/S and assisted vaginal delivery rates in this study were comparable to the result found by Shobha et al (2006) which showed the rate of spontaneous vaginal delivery was 84% with only one case of C/S and about 15% of assisted vaginal delivery 12 .…”

Section: Methodssupporting

confidence: 72%

The effect of hyoscine N– butyl bromide on the duration of active phase of labor

Alani

Salim

2013

ZJMS

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Background and objective: Hyoscine N-butyl bromide acts by inhibiting cholinergic transmission in pelvic parasympathetic ganglia and antagonizing muscarinic receptors of smooth muscles in the abdomen and pelvic organs, thus relieving spasm aiding to cervical dilation. This study is to assess the efficacy of Hyoscine butyl bromide on cervical dilation in multigravid pregnant women during the active phase of labor. Methods: A randomized clinical prospective trial was conducted in maternity hospital in Sulaimaniyah, from 1 st of January to the 1 st of July 2010. Women were consecutively randomized into: the study group (A) who received 40 mg Hyoscine N-butyl bromide by slow intravenous injection in the active phase of first stage of labor and the control group (B) who received 2ml of normal saline. Each group consists of 130 patients after excluding high risk pregnancy. Results: Mean duration of active phase of labor was 142.69 min, 258.00 min in group A and B, respectively (p-value < 0 .001). Mode of delivery and neonatal outcome were comparable. No adverse maternal or fetal effects were noted. Conclusion: Intravenous Hyoscine N-Butyl Bromide shortens the duration of active phase of labor without any unwanted fetal or maternal effects, also it effectively shortens the 2 nd and 3 rd stages of labor.

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Section: Methodssupporting

confidence: 72%

The effect of hyoscine N– butyl bromide on the duration of active phase of labor

Alani

Salim

2013

ZJMS

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“…9 Although methods to increase uterine contractility such as amniotomy and oxytocics are also used to accelerate cervical dilatation, but these methods are also associated with complications. 10 In the present study we observed an initial cervical dilatation to be lying in the range of 3-4 cm ( Table 2).…”

Section: Discussionsupporting

confidence: 61%

“…Similarly for drotaverine hydrochloride too Table 6: Distribution of subjects in three groups according to mode of delivery. 14 Khosla et al, 15 Singh et al 10 Have shown a proven efficacy of drotaverine hydrochloride over placebo and other drugs. These results are in agreement with our study.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of the effect of drotaverine hydrochloride with hyoscine butylbromide in first stage of labor

Srivastava

Sinha

Sharma

et al. 2015

Int J Basic Clin Pharmacol

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“…2,3,5 The incorporation of partogram was helped to earlier recognition of dystocia and implementation of measures at the same time. 7 There was no major difference in the percentage of normal delivery in the study as well as control groups. This was in accordance with the observations of other studies.…”

Section: Discussionmentioning

confidence: 67%

A clinical study on the effect of programmed labor on feto-maternal outcome

Chikkagowdra

2016

Int J Reprod Contracept Obstet Gynecol

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Background: Stress of labor pain disturbs the maternal autonomic functions and liberates catecholamines which predisposes to dysfunctional labor and compromise fetal oxygenation. Freedom from pain improves the environment for both mother and fetus and therapy improves obstetric outcome. The objective of the study was to evaluate the efficacy of programmed labor protocol in providing shorter, safer and relatively pain free deliveries. Methods: 100 primigravidae with term pregnancy (37-41 wks) meeting inclusion criteria were enrolled in the study. Alternate women were allocated to two groups-study group (50) and control group (50). Programmed labor protocol was initiated in study group and control group were managed expectantly as per hospital protocol. Feto maternal outcome variables were noted. Results: In study group there was a marked reduction of the active phase of labor. The mean duration of cervical dilatation was nearly double (2.3+/-0.3 cm/hr) than the control group (1.2+/-0.4cm/hr) resulting in shortening of the duration of both first as well as second stage in the study group. In the study there was 66% of women has good pain relief 20% of women has moderate pain relief. No neonatal mortality or life threatening complications were seen in both the groups. Conclusions: Programmed labor protocol can be used by all clinicians with high benefit and safety margin.

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Drotaverine hydrochloride for augmentation of labor

Abstract: Drotaverine hydrochloride is safe and effective in accelerating labor, but not effective in lessening labor pain.

Cited by 53 publications

References 4 publications

The effect of hyoscine N– butyl bromide on the duration of active phase of labor

The effect of hyoscine N– butyl bromide on the duration of active phase of labor

A comparative study of the effect of drotaverine hydrochloride with hyoscine butylbromide in first stage of labor

A clinical study on the effect of programmed labor on feto-maternal outcome

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