Drug Action on Digestive System

Holz, S

doi:10.1146/annurev.pa.08.040168.001131

Cited by 3 publications

(2 citation statements)

References 105 publications

(114 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand production of gastric ulcer would require the revitalizations of gastric mucosa by a high doe of histamine prior to the action of gastric juice. Even before 1962 some authors insisted on different origins of experimental ulcers of the stomach and duodenum [7] . In another study the evaluation of Aspirin+Pylorus Ligation (APL) and Alcohol (AL) induced acute gastric ulcer models and ulcer-healing activity using acetic acid-induced (AC) chronic ulcer model in rats.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Muralidhar¹,

Balaji²,

Bandopadhyay³

et al. 2009

American J. of Pharmacology and Toxicology

View full text Add to dashboard Cite

Problem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg −1 significantly protected the onset of coldresistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer was 42.00±2.30 and in UlGen treated rats showed 10.00±1.62. Using alcian blue stain to study the mucus secretion by mucosal cells carried out histological examination of gastric glandular mucosa. Results: The volume and acidity of gastric juice in pyloric-ligated rats was reduced in treated rats. Gastric volume (mL 100 g −1 ) in control rats showed 4.12±0.32 and in UlGen treated rats showed 2.50±0.20. Conclusion: UlGen, Cytoprotective effect may be due to the enhancement of defensive mechanism through an improvement of gastric cytoprotection as well as acid inhibition.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Muralidhar¹,

Balaji²,

Bandopadhyay³

et al. 2009

American J. of Pharmacology and Toxicology

View full text Add to dashboard Cite

show abstract

“…The hydrazine adduct, however, is unusually stable, with a K i of 10 mm, which is approximately 80 times lower than the K m of SAM. [9] The reactivity of hydrazines and hydrazides with PLP-dependent transaminases has been known for decades, [27] and the kinetics of inhibition were studied in detail long ago. [28] More recently, there have been a number of attempts to increase the potency of inhibitors of PLP-dependent enzymes that contain a reactive hydrazide.…”

Section: Stabilization Of An Azo-quinonoid Intermediatementioning

confidence: 99%

Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

et al. 2014

View full text Add to dashboard Cite

7,8-diaminopelargonic acid synthase (BioA) of Mycobacterium tuberculosis is a recently validated target for therapeutic intervention in the treatment of tuberculosis (TB). Using biophysical fragment screening and structural characterization of compounds, we have identified a potent aryl hydrazine inhibitor of BioA that reversibly modifies the pyridoxal-5’-phosphate (PLP) cofactor, forming a stable quinonoid. Analogous hydrazides also form covalent adducts that can be observed crystallographically but are incapable of inactivating the enzyme. In the X-ray crystal structures, small molecules induce unexpected conformational remodeling in the substrate binding site. We compare these conformational changes to those induced upon binding of the substrate (7-keto-8-aminopelargonic acid), and characterize the inhibition kinetics and the X-ray crystal structures of BioA with the hydrazine compound and analogs to unveil the mechanism of this reversible covalent modification.

show abstract

Science and Principles of Toxicology

2002

Food Science and Technology

View full text Add to dashboard Cite

Drug Action on Digestive System

Cited by 3 publications

References 105 publications

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

Science and Principles of Toxicology

Contact Info

Product

Resources

About