Drug addictions: new insight into causes, comorbidity and potential treatments

Follow-up Study of Drug Use, Depression, and Anxiety Reduction and Quality of Life in Addicts on Methadone Maintenance Therapy

“…Depression has a high prevalence among addicts. In this study, depression was the most commonly observed disorder, which is consistent with the results of Goldberg and Lin (27) and Holmes (28) studies. Over a relatively short period, MMT could have beneficial effects on many aspects of the life of addicts by decreasing anxiety and depression and increasing their quality of life.…”

G2B reviews: Epigenetics, epitranscriptomics, microRNAs and more: Emerging approaches to the study of genes, brain and behavior

“…Novel treatment strategies is also the topic of a review by Szumlinski and Shin , and specifically the potential for new pharmaceutical approaches to reducing craving for psychostimulant drugs, such as cocaine. These authors survey a growing body of research demonstrating that drug‐craving correlates with abnormally high activity of rodent prefrontal cortical regions, a literature that was the focus of an issue of Genes, Brain and Behavior dedicated to addiction . Szumlinski and Shin draw upon evidence that this hyper‐excitability is related to excess prefontal glutamate transmission, and importantly, to reduced (metabotropic MGlu1/5) glutamate receptor driven by excess kinase signaling therein.…”