Drug Administration

Nebendahl, Klaus; Hauff, Peter

doi:10.1007/978-3-642-12945-2_8

Cited by 5 publications

(8 citation statements)

References 48 publications

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“…Instead enteral route should be adopted to administer drug because it allows administration of large amount of non-sterile solutions. Moreover, absorption of the substance takes place over the whole length of gastro-intestinal tract (Nebendahl and Hauff, 2011).…”

Section: Discussionmentioning

confidence: 99%

Management of diabetic complications: A chemical constituents based approach

Singh

Kaur

Kishore

et al. 2013

Journal of Ethnopharmacology

121

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Section: Discussionmentioning

confidence: 99%

Management of diabetic complications: A chemical constituents based approach

Singh

Kaur

Kishore

et al. 2013

Journal of Ethnopharmacology

121

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“…As with other practical issues discussed in this article, some basic considerations apply before it is possible to answer this question correctly. Basic principles of how to properly choose the route of administration are comprehensively summarized by Nebendahl and Hauff [26]. The following just gives a summary of some of their recommendations.…”

Section: Pitfalls In the Route Of Administration And The Pharmacokinementioning

confidence: 99%

“…So, if i. p. injection is not the method of choice, what should be the preferred route of administration? According to Nebendahl and Hauff [26], the preferred route of administration is the enteral one which involves the introduction of substances into the gastrointestinal tract via the mouth using a feeding needle. The advantage of enteral administration is the fact that it makes it possible to give comparatively large amounts of nonsterile substances or solutions.…”

Section: Pitfalls In the Route Of Administration And The Pharmacokinementioning

confidence: 99%

“…These microorganisms are found under physiological conditions only in the large intestine, and the enzymatic metabolism applies only to those substances that are not absorbed in the upper intestinal tract. The disadvantage of oral administration therefore is that enzymes of microorganisms can alter substances before they are absorbed in the bowel [26]. If the metabolites are not biologically active, the administration of these substances might not be affected.…”

Section: Pitfalls In the Route Of Administration And The Pharmacokinementioning

confidence: 99%

“…Considering the advantages and disadvantages of oral and intraperitoneal administration, what would be the easiest method of administration? According to Nebendahl and Hauff [26], the simplest method to administer a substance is to mix it with food or drinking water. However, this method is neither very accurate nor is it practicable with substances that are insoluble or chemically unstable.…”

Section: Pitfalls In the Route Of Administration And The Pharmacokinementioning

confidence: 99%

See 2 more Smart Citations

What Is the Best Strategy for Preclinical Testing of Botanicals? A Critical Perspective

Butterweck

Nahrstedt

2012

Planta Med

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The development of a new drug is generally marked by a number of preclinical investigations in a sequential order with regard to contents and logic. However, ethnopharmacology often uses the ?reverse pharmacology? approach, which is based on anecdotal therapeutic effects of plants in ancient texts or based on the empirical knowledge of traditional healers. While this approach could successfully lead to new therapeutic applications by using sophisticated techniques and appropriate bioassays in a logical order, unfortunately there is an exponentially increasing number of reports of pharmacological effects of botanical extracts with insignificant bioactivities obtained in often irrelevant in vitro bioassays. The interpretation based on in vitro data can only be misleading since the pharmacokinetic properties of a compound are ignored, unacceptable high dosages of extracts are tested, or metabolism to inactive metabolites is not considered. Further, many natural products are prodrugs that need to be metabolized in vivo by the intestinal microflora or by mammalian phase I/II metabolism. Frequently, attempts are made to master poor pharmacokinetics by administering the extract intraperitoneally or intravenously, clearly moving away from the traditional oral application. In this review article, it is proposed that preclinical testing strategies of botanicals should start with the in vivo examination of extracts in relevant animal models to substantiate the ethnopharmacological/ethnopharmaceutical use, followed by bioguided fractionation processes using an adequate in vitro model, further followed by pharmacokinetic studies and final in vivo testing of isolated compounds. With our article we would like to encourage authors, reviewers and editors to implement this strategy for the design of experiments and for the reviewing and editing process of manuscripts.

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PRECLINICAL (IN VIVO) AND LABORATORY (IN VITRO) EVIDENCE OF PHYTOMEDICINE EFFICACY

Abdul

Huang

2015

Phytotherapies

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Drug Administration

Cited by 5 publications

References 48 publications

Management of diabetic complications: A chemical constituents based approach

Management of diabetic complications: A chemical constituents based approach

What Is the Best Strategy for Preclinical Testing of Botanicals? A Critical Perspective

PRECLINICAL (IN VIVO) AND LABORATORY (IN VITRO) EVIDENCE OF PHYTOMEDICINE EFFICACY

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