Drug allergy in Sjögren's syndrome

Katz, Joseph; Marmary, Yitzhak; Livneh, Avraham; Danon, Yehuda L.

doi:10.1016/0140-6736(91)92202-d

Cited by 13 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high number of allergic reactions in the SjÎgren's syndrome group is comparable to the ¢ndings of Katz et al (5). In contrast to previous reports we found a high frequency of trimethoprim [or sulfamethoxazole-trimethoprim (SMX-TMP)] associated non-allergic reactions.…”

Section: Resultssupporting

confidence: 80%

“…The reaction is di¡erent from type I immediate hypersensitivity reaction and typically includes fever, malaise, head-and backache, and often central nervous system symptoms such as confusion and even aseptic meningitis (3). SjÎgren's syndrome patients have previously been suggested to have a high overall frequency of allergic drug reactions (4), but only one report has been published during the last twenty years (5).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Adverse Drug Reactions in Sjögren's Syndrome: Frequent allergic reactions and a specific trimethoprim-associated systemic reaction

Antonen

Markula²,

Pertovaara³

et al. 1999

Scandinavian Journal of Rheumatology

View full text Add to dashboard Cite

Trimethoprim-associated systemic reactions, including aseptic meningitis, have been reported to be very rare adverse drug reactions. Patients with Sjögren's syndrome have been overrepresented, but no epidemiological surveys of the reaction have been conducted. To study the overall frequency of adverse drug reactions, and especially trimethoprim-associated reactions, we interviewed 85 primary Sjögren's syndrome patients and compared the results with those of 45 similarly interviewed osteoarthritis patients. Antimicrobial allergy was more common among Sjögren's syndrome patients than in osteoarthritis patients (46% vs. 27%). Eleven Sjögren's syndrome patients (13%), but no osteoarthritis patient, had experienced at least a partial, non-allergic systemic reaction with trimethoprim. Of them five (6%) had had a full-blown systemic reaction including both chills/fever and headache/backache and at least one of the following: malaise, vomiting, dizziness, confusion or meningeal irritation. Our findings confirm that allergic reactions to antimicrobials are frequent in Sjögren's syndrome. In addition to allergic reactions Sjögren's syndrome patients are prone to a specific trimethoprim-associated systemic reaction. This should be remembered when prescribing antimicrobials.

show abstract

Section: Resultssupporting

confidence: 80%

mentioning

confidence: 99%

Adverse Drug Reactions in Sjögren's Syndrome: Frequent allergic reactions and a specific trimethoprim-associated systemic reaction

Antonen

Markula²,

Pertovaara³

et al. 1999

Scandinavian Journal of Rheumatology

View full text Add to dashboard Cite

show abstract

“…Other risk factors for developing adverse drug reactions involve chemistry of the drug, degree of drug exposure (dose, duration, and frequency), genetic and constitutional factors, and concurrent medical illness (4,5). The frequency of drug allergy is increasing in patients with SLE or Sjogren's syndrome (6,7), but our patient, who suffered from RSD, had no past or family history of drug allergy or such disorders. Some data suggest that an immunological mechanism is associ-ated with the pathogenesis of RSD (8).…”

Section: Discussionmentioning

confidence: 77%

A Case of Drug Eruption Due to Simultaneous Sensitization with Three Different Kinds of Drugs

Nagayama

Nakamura

Shinkai

1996

The Journal of Dermatology

View full text Add to dashboard Cite

We reported a case of drug eruption induced by combined treatment with three different kinds of drugs, amoxapine, mexiletine hydrochloride and cefaclor. A 63-year-old Japanese woman suffering from 11 years of standing reflex sympathetic dystrophy developed multiple erythematous papules on her trunk and extremities after taking 14 kinds of drugs. The provocation challenge produced positive reactions to amoxapine, mexiletine hydrochloride, and cefaclor, but was negative to the other drugs. We discussed the mechanism of simultaneous sensitization to three different kinds of drugs in our case.

show abstract

“…The high anti‐SS‐A antibody titer and severe dry eyes suggested Sjögren's syndrome or another autoimmune disease, although no other autoimmune symptoms were observed. Patients with Sjögren's syndrome have higher rates of drug allergies than healthy individuals 3 , and autoimmune factors may facilitate the development of TEN.…”

Section: Figurementioning

confidence: 99%