Drug and Hormonal Regulation of the Beta-Adrenergic Receptor—Adenylate Cyclase System

Stiles, Gary L.

doi:10.1007/978-1-4612-0463-3_8

Cited by 4 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In animal production, b-agonists have been determined to be potent growth promoters leading to increased skeletal muscle mass and protein accretion and/or decreased fat deposition. The b-adrenergic responsiveness is considered, in general, to be dependent on b-adrenergic receptor density (Stiles, 1991;Kim et al 1992). Further, chickens have been shown to be insensitive to b-agonist administration (Weppelman, 1984;Wellenreiter, 1991).…”

Section: Discussionmentioning

confidence: 99%

Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

et al. 1999

View full text Add to dashboard Cite

The present study was conducted to determine the role of α-lipoic acid (LA) in plasma metabolites, hepatic O2 consumption, and β-adrenergic response in broilers. In Expt 1, 12-d-old female broiler chicks were divided into three dietary groups and fed on diets with or without LA (5 or 50 mg/kg) until 4 or 6 weeks of age, as a 2 × 3 factorial arrangement. The dietary LA had no effect on growth rates (body weight, abdominal fat, breast muscle, and liver). The higher level of LA increased plasma non-esterified fatty acid and decreased plasma triacylglycerol concentrations only at 6 weeks of age. A 42 % increase in hepatic respiration was observed in the 4-week-old chickens given 50 mg LA/kg diet. In Expt 2, 3-d-old female broiler chicks were treated with or without dietary LA at 50 mg/kg. At 30 and 31 d old, isoproterenol (2 mg/kg body weight per h) was continuously infused into a wing vein for 2 h, and changes in plasma glucose, triacylglycerol, and non-esterified fatty acid concentrations were analysed. Isoproterenol increased plasma glucose over basal levels maximally at 60 min. Furthermore, the glucose increase in the LA-treated chickens was 35% greater than that of the controls at this time. Plasma non-esterified fatty acid and triacylglycerol concentrations were decreased by the isoproterenol infusion, regardless of LA administration. Therefore, the present study suggests that dietary LA has repartitioning effects on energy metabolism in chickens (although this depends on age-related metabolic state) and is a possible facilitator in the β-adrenergic response of plasma glucose to a β-agonist.

show abstract

Section: Discussionmentioning

confidence: 99%

Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

et al. 1999

View full text Add to dashboard Cite

show abstract

“…This receptor up-or downregulation is known from long-lasting β-receptor agonist or antagonist therapy respectively, and from physiological alterations of the catecholamine concentrations [33]. A reduced or increased activity of sympathoadrenal system following physical conditioning does not support, however, a generalized adaptive mechanism of the β-adrenergic system because catecholamine responses to training are tissue specific.…”

Section: Discussionmentioning

confidence: 96%

“…An inverse relationship between agonist levels and β-adrenoceptor function has been described extensively [33]. This receptor up-or downregulation is known from long-lasting β-receptor agonist or antagonist therapy respectively, and from physiological alterations of the catecholamine concentrations [33].…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Adaptations of the β-adrenoceptor-adenylyl cyclase system in rat skeletal muscle to endurance physical training

Nieto

Díaz‐Laviada

Malpartida

et al. 1997

Pfl�gers Archiv European Journal of Physiology

View full text Add to dashboard Cite

beta-Adrenergic mechanisms may be important in the adaptation of skeletal muscle to endurance training. beta-Adrenergic signal transduction was examined in the gastrocnemius muscle of rats submitted to a progressive, 12-week treadmill running program and compared with sedentary controls. beta-Adrenoceptor density was significantly lower in exercised rats than in controls. The affinity constant for [125I]-(-) iodocyanopindolol binding was not different among the various groups. Adenosine cyclic monophosphate formation was significantly decreased in trained animals when isoproterenol plus guanosine triphosphate or forskolin plus Mn2+ were used to stimulate adenylyl cyclase. Immunoblot analyses revealed that the amount of the alpha-subunit of stimulatory guanine nucleotide-binding protein (Gs,alpha), both the small and the large isoforms, also decreased with physical exercise. Thus, the present report shows that endurance training results in alterations in beta-adrenergic receptor density, adenylyl cyclase activity and Gs protein level in rat gastrocnemius muscle.

show abstract

Structure and Function of the Adrenergic Receptor Family

Roth

Lefkowitz

Caron

1991

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Drug and Hormonal Regulation of the Beta-Adrenergic Receptor—Adenylate Cyclase System

Cited by 4 publications

References 80 publications

Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

Adaptations of the β-adrenoceptor-adenylyl cyclase system in rat skeletal muscle to endurance physical training

Structure and Function of the Adrenergic Receptor Family

Contact Info

Product

Resources

About