Drug Assay in Ground Tissues: Example of Ketoprofen Diffusion into Tonsillar Tissue

Lapicque, Françoise; Jankowski, R.; Netter, Patrick; Bannwarth, B; Guillemin, Christine; Béné, Marie‐Christine; Monot, C.; Wayoff, M

doi:10.1002/jps.2600790909

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…45 Moreover, KLS is able to penetrate extensively into the upper airways, making it an optimal solution in the treatment of inflammation in course of pharyngitis, otitis, sinusitis. 46,47 The lysine salt of ketoprofen also demonstrated an analgesic activity two times stronger than ketoprofen. 48 One of the main improvements of the salification process with the amino acid lysine was the possibility to reduce the effective daily dosage (DDD) versus ketoprofen.…”

Section: Ketoprofen and Respiratory Infectionsmentioning

confidence: 99%

Clinical use of ketoprofen lysine salt: a reappraisal in adolescents with acute respiratory infections

Marseglia,

Ciprandi

2023

Allergol Immunopathol

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Upper respiratory infections are widespread, and they are mainly of viral etiology. It has to be remarked that every infection is always associated with an inflammatory response. Inflammation implicates a cascade of bothersome symptoms, including fever, pain (headache, myalgia, and arthralgia), malaise, and respiratory complaints. As a result, anti-inflammatory medications could be beneficial as they act on different pathogenetic pathways. The ketoprofen lysine salt (KLS) has a potent anti-inflammatory activity associated with effective analgesic and antipyretic effects and has a valuable safety profile. However, adolescents present peculiar psychological characteristics that determine their difficulty to be managed. In this regard, an adolescent with a respiratory infection requires a prompt and adequate cure. KLS, thanks to its pharmacologic profile, could be favorably used in this regard. A recent primary-care experience outlined its effectiveness in this issue.

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Section: Ketoprofen and Respiratory Infectionsmentioning

confidence: 99%

Clinical use of ketoprofen lysine salt: a reappraisal in adolescents with acute respiratory infections

Marseglia,

Ciprandi

2023

Allergol Immunopathol

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“…Tissue specimens were reduced to fine powder using a freeze grinder filled with liquid nitrogen, by means of an alternating electromagnetic field, as previously described [4]. Tissue specimens were reduced to fine powder using a freeze grinder filled with liquid nitrogen, by means of an alternating electromagnetic field, as previously described [4].…”

Section: Analytical Proceduresmentioning

confidence: 99%

Tenoxicam concentrations in synovium and joint cartilage in humans

et al. 1991

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Tenoxicam is an NSAID of the oxicam group. Its distribution in articular tissues was investigated in 12 patients who required total arthroplasty of the hip. They were given tenoxicam 20 mg once daily for 8 to 30 days before surgery. Blood, synovium and cartilage samples were taken concurrently during surgery, about 14 hours after the last tenoxicam dose. The tissues were ground using a freeze grinder. Tenoxicam was assayed by HPLC. Tenoxicam concentrations averaged 6.21 +/- 3.81 micrograms/ml in plasma, 7.56 +/- 4.67 micrograms/g in synovium and 2.05 +/- 1.43 micrograms/g in cartilage. The individual synovium/cartilage ratios ranged from 1.9 to 9.7. Finally tenoxicam exhibited more affinity for its target organ (synovial tissue) than for joint cartilage.

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pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery

Sousa¹,

Nunes

Proença³

et al. 2012

Colloids and Surfaces B: Biointerfaces

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Drug Assay in Ground Tissues: Example of Ketoprofen Diffusion into Tonsillar Tissue

Cited by 4 publications

References 20 publications

Clinical use of ketoprofen lysine salt: a reappraisal in adolescents with acute respiratory infections

Clinical use of ketoprofen lysine salt: a reappraisal in adolescents with acute respiratory infections

Tenoxicam concentrations in synovium and joint cartilage in humans

pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery

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