Drug/bioactive eluting chitosan composite foams for osteochondral tissue engineering

Samie, Muhammad; Khan, Ather Farooq; Rahman, Saeed Ur; Iqbal, Haffsah; Yameen, Muhammad Arfat; Chaudhry, Aqif Anwar; Galeb, Hanaa A.; Halcovitch, Nathan R.; Hardy, John G.

doi:10.1016/j.ijbiomac.2022.12.293

Cited by 12 publications

(29 citation statements)

References 92 publications

(90 reference statements)

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“…Composite materials, which are a combination of components of sometimes very different properties into one common system, are one of the most interesting pursuits of contemporary material chemistry. Polysaccharide nanocomposites have become important materials over the last decade [1][2][3][4][5][6]. They are a novel method of preparing of soft and hard nanomaterials based on hydrogels and metal or carbon nanostructures, respectively, as well as creating a great alternative to nanocomposites based on synthetic polymers.…”

Section: Introductionmentioning

confidence: 99%

Chitosan–Silica Composites for Adsorption Application in the Treatment of Water and Wastewater from Anionic Dyes

Błachnio

Zienkiewicz-Strzałka

Deryło–Marczewska

et al. 2023

IJMS

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A series of new types of composites (biopolymer–silica materials) are proposed as selective and effective adsorbents. A new procedure for the synthesis of chitosan–nanosilica composites (ChNS) and chitosan–silica gel composites (ChSG) using geometrical modification of silica and mechanosorption of chitosan is applied. The highest adsorption efficiency was achieved at pH = 2, hence the desirability of modifications aimed at stabilizing chitosan in such conditions. The amount of chitosan in the synthesis grew to 1.8 times the adsorption capacity for the nanosilica-supported materials and 1.6 times for the silica gel-based composites. The adsorption kinetics of anionic dyes (acid red AR88) was faster for ChNS than for ChSG, which results from a silica-type effect. The various structural, textural, and physicochemical aspects of the chitosan–silica adsorbents were analyzed via small-angle X-ray scattering, scanning electron microscopy, low-temperature gas (nitrogen) adsorption, and potentiometric titration, as well as their adsorption effectiveness towards selected dyes. This indicates the synergistic effect of the presence of dye-binding groups of the chitosan component, and the developed interfacial surface of the silica component in composites.

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Section: Introductionmentioning

confidence: 99%

Chitosan–Silica Composites for Adsorption Application in the Treatment of Water and Wastewater from Anionic Dyes

Błachnio

Zienkiewicz-Strzałka

Deryło–Marczewska

et al. 2023

IJMS

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“…The scaffold was loaded with triamcinolone acetonide (to counter the elevated levels of tumor necrosis factor-α and interleukins at the defect site that downregulates ECM production) or transforming growth factor-β1 (for pro-osteogenic activity). The drug-loaded scaffold served dual functionality in terms of local delivery within the extracellular environment, along with facilitating support for the cells to organize [189].…”

Section: Cartilage Tissue Regenerationmentioning

confidence: 99%

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

et al. 2023

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Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.

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“…However, the significant differences between the articular cartilage and subchondral tissue have limited the success of OC tissue engineering 9,10 . Selection of appropriate biomaterials, fabrication methods, structural design of multilayered or gradient 3D scaffolds, cells, and different culture conditions are crucial requirements for a successful development of suitable constructs for mimicking the native physiological function and mechanochemical environment of OC tissues 11–13 …”

Section: Introductionmentioning

confidence: 99%

“…9,10 Selection of appropriate biomaterials, fabrication methods, structural design of multilayered or gradient 3D scaffolds, cells, and different culture conditions are crucial requirements for a successful development of suitable constructs for mimicking the native physiological function and mechanochemical environment of OC tissues. [11][12][13] The developed scaffold manufacturing techniques have helped researchers to fabricate multilayered scaffolds (compared to the single or bilayered ones), in which an intermediate layer exists between the bony and chondral layers 14,15 to resemble the role of native calcified cartilage. Such multilayered structures are anticipated to closely mimic the OC tissue microstructure and endure the joint shear forces after implantation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of rabbit adipose derived stem cells fate in perfused multilayered silk fibroin composite scaffold for Osteochondral repair

Zadegan,

Vahidi,

Nourmohammadi

et al. 2024

J Biomed Mater Res

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Development of osteochondral tissue engineering approaches using scaffolds seeded with stem cells in association with mechanical stimulations has been recently considered as a promising technique for the repair of this tissue. In this study, an integrated and biomimetic trilayered silk fibroin (SF) scaffold containing SF nanofibers in each layer was fabricated. The osteogenesis and chondrogenesis of stem cells seeded on the fabricated scaffolds were investigated under a perfusion flow. 3‐Dimethylthiazol‐2,5‐diphenyltetrazolium bromide assay showed that the perfusion flow significantly enhanced cell viability and proliferation. Analysis of gene expression by stem cells revealed that perfusion flow had significantly upregulated the expression of osteogenic and chondrogenic genes in the bone and cartilage layers and downregulated the hypertrophic gene expression in the intermediate layer of the scaffold. In conclusion, applying flow perfusion on the prepared integrated trilayered SF‐based scaffold can support osteogenic and chondrogenic differentiation for repairing osteochondral defects.

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Drug/bioactive eluting chitosan composite foams for osteochondral tissue engineering

Cited by 12 publications

References 92 publications

Chitosan–Silica Composites for Adsorption Application in the Treatment of Water and Wastewater from Anionic Dyes

Chitosan–Silica Composites for Adsorption Application in the Treatment of Water and Wastewater from Anionic Dyes

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Evaluation of rabbit adipose derived stem cells fate in perfused multilayered silk fibroin composite scaffold for Osteochondral repair

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