Drug delivery: Brain food

Hoag, Hannah

doi:10.1038/510s6a

Cited by 4 publications

(1 citation statement)

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“…In regenerative neuroscience, the combined implantation of cells and different biomaterials to increase the viability of cellular grafts constitutes a very promising approach in full expansion [9]. In this context hydrogels rise as a powerful and versatile group of architectonic elements for cell encapsulation and brain reconstruction due to their special chemical and physical structures with stiffness modules in the range of the soft tissues such as the brain.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality

et al. 2018

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Abstract:The use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring normal brain function in neurodegenerative diseases and cerebrovascular disorders. Hydrogel polymers show unique mechanical stiffness properties in the range of living soft tissues such as nervous tissue. Furthermore, the use of these polymers drastically enhances the engraftment of stem cells as well as their capacity to produce and deliver neuroprotective and neuroregenerative factors in the host tissue. Along this article, we review past and current trends in experimental and translational research to understand the opportunities, benefits, and types of tentative hydrogel-based applications for the treatment of cerebral disorders. Although the use of hydrogels for brain disorders has been restricted to the experimental area, the current level of knowledge anticipates an intense development of this field to reach clinics in forthcoming years.

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Section: Introductionmentioning

confidence: 99%