Drug Delivery: Dendritic Mesoporous Silica Nanoparticles for pH‐Stimuli‐Responsive Drug Delivery of TNF‐Alpha (Adv. Healthcare Mater. 13/2017)

Abstract

In article number 1700012, Helmut Jonuleit and co-workers utilize dendritic mesoporous silica nanoparticles for drug delivery to increase the efficacy of anti-tumor drug TNF-a, while decreasing its side-effects.

Kinetically Controlled Dendritic Mesoporous Silica Nanoparticles: From Dahlia- to Pomegranate-like Structures by Micelle Filling

“…Moreover, MSNs have been used as templates in the preparation of soft polymer- and carbon-based materials with broad applications. − Traditional MSNs such as SBA-15 and MCM-41 type materials have relatively small pore sizes. The successful synthesis of KCC-1 with both large dendritic pores (5–30 nm) and monodispersed uniform particle sizes (250–450 nm) has sparked significant interest in synthesis − and applications of this new type of dendritic MSNs (DMSNs), specifically in the cellular delivery of various cargo molecules. ,,− Significant progress has been made in the structural control over DMSNs (e.g., particle size, ,, pore size, ,,, and bimodal pores ,,, ) and their assembly strategies, including biphasic synthesis, microemulsion templating, ,, the aggregation of composite micelles in the presence of competing anions in aqueous systems, , and the assembly from lamellar subunits. ,, To date, these mechanisms are mainly focused on the formation of DMSNs as an end product. The structural heterogeneity of DMSNs controlled by reaction kinetics as well as its significance in the applications of DMSNs has rarely been reported.…”