Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems

Abstract

Over the past few decades the mucoadhesive buccal drug delivery system has received a great deal of attention to develop mucoadhesive dosage forms to enable the prolonged retention at the site of action, providing a controlled release of drug for improved therapeutic outcome. Mucoadhesive drug delivery gives facility to include a permeation enhancer/enzyme inhibitor or pHmodifier in the formulation and versatility in designing as multidirectional or unidirectional release systems for local and systemic action. Local delivery to tissues of the oral cavity has a number of applications, including treatment of local conditions such as periodontal disease, bacterial and fungal infections, and aphthous stomatitis and vesiculo bullous diseases. For the treatment of chronic diseases, the mucoadhesive buccal drug delivery system allows easily accessibility and is generally well-accepted for administeringdrugs by systemic action.

Chemical Modification of Hyaluronic Acid for Intraoral Application

“…Furthermore, the in vitro wash‐off test on porcine buccal mucosa confirmed the mucoadhesive findings as shown in Figure . The obtained results are explained by the evidential theory of enhanced mucoadhesive properties of thiolated HA in view of the formation of covalent bonds between thiol groups of the polymer and CYS‐rich subdomains of glycoproteins in the mucus layer . Freshly excised porcine mucosa was used as the substrate to assess the in vitro mucoadhesive strength.…”

“…The obtained results are explained by the evidential theory of enhanced mucoadhesive properties of thiolated HA in view of the formation of covalent bonds between thiol groups of the polymer and CYS-rich subdomains of glycoproteins in the mucus layer. 36,37 Freshly excised porcine mucosa was used as the substrate to assess the in vitro mucoadhesive strength. A prolonged residence time also leads to a better patient compliance because the interval of drug application can be reduced and an increased concentration of the drug at the target site can be achieved by this close attachment.…”

Hot-melts in buccoadhesive patches: An approach for bioavailability enhancement of highly-metabolized drugs with short elimination half-life

“…One of the approaches to overcome this problem is to formulate such drugs into buccoadhesive patches that will help to avoid the extensive first pass effect of the drug in the liver and thus enhance its bioavailability [1]. If these drugs are also characterized by short elimination half-life that necessitates frequent administration, drug extended release is required.…”

Review on Mucoadhesive Drug Delivery System with Special Emphasis on Buccal Route: An Important Tool in Designing of Novel Controlled Drug Delivery System for the Effective Delivery of Pharmaceuticals

“…Wide varieties of polymers are use from that chitosan has greatest binding capacity than other. Viscous liquid formulations are preferred to coat buccal cavity either as vehicle or as protectant [39].…”

“…The following formula can be used for determining the tensile strength of buccal mucoadhesive device. For the measurement of tensile strength, various instruments are used that are as follows [39].…”