Drug delivery system based on nanobubbles

Jin, Juan; Yang, Li; Chen, Feng; Gu, Ning

doi:10.1002/idm2.12050

Cited by 55 publications

(32 citation statements)

References 166 publications

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“…In the traditional method, hydrophobic molecular dyes are directly encapsulated by surfactants, [ 14 ] leading to aggregation‐caused quenching (ACQ) in nanoparticles due to insufficiently disassembled dyes ( Figure a). Conversely, the co‐assembly strategy inhibits the occurrence of ACQ by ensuring sufficient disassembly of the dyes, which obviously improves their brightness performance.…”

Section: Resultsmentioning

confidence: 99%

Ultra‐Bright Heptamethine Dye Clusters Based on a Self‐Adaptive Co‐Assembly Strategy for NIR‐IIb Biomedical Imaging

Dang,

Liu,

et al. 2023

Advanced Materials

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Despite the wide range of applications of bright NIR‐II polymethine scaffolds in biomedical imaging, their solvatochromism and aggregation‐caused quenching (ACQ) effects in aqueous solutions limit their inherent brightness using traditional encapsulation methods, and effective hydrophilization strategies are still scarce. Here, we synthesize and PEGylate a new set of Flav dyes, followed by manufacturing DSPE@FlavP2000 nanoparticles using a self‐adaptive co‐assembly strategy to overcome these limitations. FlavP2000 can autonomously adjust its conformation when co‐assembled with DSPE‐PEG2000, resulting in high‐efficiency luminescence (approximately 44.9% fluorescence of Flav in DMSO). DSPE@FlavP2000 enables NIR‐IIb (>1500 nm) angiography with high signal‐to‐noise ratios. Notably, this co‐assembly can occur in situ between FlavP2000 with proteins in the living body based on a novel mechanism of brightness activation induced by disassembly (BAD), achieving consistent brightness as DSPE@FlavP2000 in blood or serum. The self‐adaptive co‐assembly strategy can be enhanced by incorporating an IPA moiety, which dynamically binds to albumin, to prolong the dye's blood circulation time. Thus, the “enhanced” BAD is successfully applied to long‐term vascular imaging and sciatic nerve imaging. Both the self‐adaptive co‐assembly strategy and BAD phenomenon improve the selectivity and availability of the hydrophilization methods, paving the way for efficient biological applications of polymethine dyes.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Ultra‐Bright Heptamethine Dye Clusters Based on a Self‐Adaptive Co‐Assembly Strategy for NIR‐IIb Biomedical Imaging

Dang,

Liu,

et al. 2023

Advanced Materials

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“…Therefore, use of nanobubble technology to promote germination in high-value plants has the potential to improve seed utilization and reduce germination costs, while increasing the market competitiveness and genetic biodiversity of recalcitrant seeds. Moreover, this novel finding suggests that BONB technology may not only advance the market for recalcitrant seeds and their biological value, but also will have an impact in medical applications such as ultrasound imaging, drug delivery, and cancer therapy 40 , 41 .…”

Section: Discussionmentioning

confidence: 98%

Accelerated germination of aged recalcitrant seeds by K+-rich bulk oxygen nanobubbles

Kim

Shoji²,

Kobayashi³

et al. 2023

Sci Rep

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Bulk nanobubbles, measuring less than 200 nm in water, have shown their salient properties in promoting growth in various species of plants and orthodox seeds, and as potential drug-delivery carriers in medicine. Studies of recalcitrant seeds have reported markedly increased germination rates with gibberellin treatment; however, neither the mechanism promoting germination nor the implication for food safety is well elucidated. In our study, recalcitrant wasabi (Eutrema japonicum) seeds treated with bulk oxygen nanobubbles (BONB) containing K+, Na+, and Cl− (BONB-KNaCl) showed significantly accelerated germination. As germination progressed, 99% of K+ ions in the BONB-KNaCl medium were absorbed by the seeds, whereas Ca2+ ions were released. These results suggest that the germination mechanism involves the action of K+ channels for migration of K+ ions down their concentration gradient and Ca2+ pumps for the movement of Ca2+ ions, the first potential discovery in germination promotion in recalcitrant seeds using nutrient solutions with BONB-KNaCl.

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“…The US employs high-frequency sound waves emitted from a transducer placed against the skin and reflected differently by different organs and tissues. The contrast of ultrasound is dependent on the sound speed, sound attenuation, backscatter, and imaging algorithm [ 19 , 29 , 30 , 31 ].…”

Section: Ultrasound (Us)mentioning

confidence: 99%

The Role of Molecular Imaging in Personalized Medicine

Salih

Elliyanti

Alkatheeri³

et al. 2023

JPM

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The concept of personalized medicine refers to the tailoring of medical treatment to each patient’s unique characteristics. Scientific advancements have led to a better understanding of how a person’s unique molecular and genetic profile makes them susceptible to certain diseases. It provides individualized medical treatments that will be safe and effective for each patient. Molecular imaging modalities play an essential role in this aspect. They are used widely in screening, detection and diagnosis, treatment, assessing disease heterogeneity and progression planning, molecular characteristics, and long-term follow-up. In contrast to conventional imaging approaches, molecular imaging techniques approach images as the knowledge that can be processed, allowing for the collection of relevant knowledge in addition to the evaluation of enormous patient groups. This review presents the fundamental role of molecular imaging modalities in personalized medicine.

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Drug delivery system based on nanobubbles

Cited by 55 publications

References 166 publications

Ultra‐Bright Heptamethine Dye Clusters Based on a Self‐Adaptive Co‐Assembly Strategy for NIR‐IIb Biomedical Imaging

Ultra‐Bright Heptamethine Dye Clusters Based on a Self‐Adaptive Co‐Assembly Strategy for NIR‐IIb Biomedical Imaging

Accelerated germination of aged recalcitrant seeds by K+-rich bulk oxygen nanobubbles

The Role of Molecular Imaging in Personalized Medicine

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