Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15

Abstract

In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1–SBA-15|EO5: 8–36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionally, SBA-15 loaded with EO (SBA-15|EO3) does not disturb viability of peritoneal macrophages. SBA-15|EO3 causes inhibition of tumor cell proliferation and triggers apoptosis, connected with caspase activation, upregulation of Bax, as well as Bcl-2 and Bim downregulation along with amplification of poly-(ADP-ribose)-polymerase (PARP) cleavage fragment. Thus, the mesoporous SBA-15 is a promising carrier of the water-insoluble drug emodin.

Influence of bridged monomer on porosity and sorption properties of mesoporous silicas functionalized with diethylenetriamine groups

“…In the case of the samples R3 and R4 the releasing profile is close to linear in that range without the so-called burst effect (i.e., initial abrupt releasing of the matrix) which is a very desirable feature of any controlled releasing system (CDS). In the literature there is a lot of reports describing applications of silica as CDSs due to their tailored porosity and surface chemistry (Krajnović et al 2018;Rosenholm and Lindén 2008;Song et al 2005;Vallet-Regí et al 2007). Thus the synthesis approach presented here based on co-condensation of three monomers can be applied for more precise tuning of the releasing profiles of the pharmaceuticals from the silica-based CDSs.…”

The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss

“…SBA-15 was synthesized by sol-gel method and subsequently calcined, according to the literature procedure [39]. Functionalization of SBA-15 mesoporous silica was performed with (3-chloropropyl)triethoxysilane (CPTS; → SBA-15p).…”

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

“…Emodin, a naturally occurring anthraquinone, has a wide range of pharmacological properties that make it an attractive candidate for cancer therapeutics such as its ability to induce apoptosis, cell cycle arrest, and inhibit DNA synthesis [20–28]. In cancers affecting the digestive tract, Emodin decreased metastasis, reduced survival signaling, and enhanced antitumor effects of other chemotherapeutic agents [5, 31–36]. Our data shows Emodin reduced the proliferation of CoCa cells in a concentration and time-dependent manner.…”