Drug Delivery Systems of Natural Products in Oncology

Colone, Marisa; Calcabrini, Annarica; Stringaro, Annarita

doi:10.3390/molecules25194560

Cited by 58 publications

(34 citation statements)

References 171 publications

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“…Despite GO’s solubility in aqueous media, it has a charged screening effect that makes GO flakes aggregate [ 19 ]. The PEGylation process makes GO become more biocompatible and stable in all biological solutions [ 20 ]. This permits the delivery of anticancer drugs that bind to the graphene oxide surface through π–π stacking [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Anticancer Molecular Mechanism of Protocatechuic Acid Loaded on Folate Coated Functionalized Graphene Oxide Nanocomposite Delivery System in Human Hepatocellular Carcinoma

et al. 2021

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Liver cancer is listed as the fifth-ranked cancer, responsible for 9.1% of all cancer deaths globally due to its assertive nature and poor survival rate. To overcome this obstacle, efforts have been made to ensure effective cancer therapy via nanotechnology utilization. Recent studies have shown that functionalized graphene oxide (GO)-loaded protocatechuic acid has shown some anticancer activities in both passive and active targeting. The nanocomposites’ physicochemical characterizations were conducted. A lactate dehydrogenase experiment was conducted to estimate the severity of cell damage. Subsequently, a clonogenic assay was carried out to examine the colony-forming ability during long-term exposure of the nanocomposites. The Annexin V/ propidium iodide analysis showed that nanocomposites induced late apoptosis in HepG2 cells. Following the intervention of nanocomposites, cell cycle arrest was ascertained at G2/M phase. There was depolarization of mitochondrial membrane potential and an upregulation of reactive oxygen species when HepG2 cells were induced by nanocomposites. Finally, the proteomic profiling array and quantitative reverse transcription polymerase chain reaction revealed the expression of pro-apoptotic and anti-apoptotic proteins induced by graphene oxide conjugated PEG loaded with protocatechuic acid drug folic acid coated nanocomposite (GOP–PCA–FA) in HepG2 cells. In conclusion, GOP–PCA–FA nanocomposites treated HepG2 cells exhibited significant anticancer activities with less toxicity compared to pristine protocatechuic acid and GOP–PCA nanocomposites, due to the utilization of a folic acid-targeting nanodrug delivery system.

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Section: Discussionmentioning

confidence: 99%

Anticancer Molecular Mechanism of Protocatechuic Acid Loaded on Folate Coated Functionalized Graphene Oxide Nanocomposite Delivery System in Human Hepatocellular Carcinoma

et al. 2021

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“…In addition, almost all of the drugs utilized at the present are associated with many other disadvantages including fast metabolism, nonspecific, low bioavailability and stability, which subsequently leads limited therapeutic index. In addition, chemotherapy is the only therapeutic option in NSCLC patients, with metastatic stage, although 90% of the cases end in death as they cannot be cured via surgery 7 . Alternative strategies are required to circumvent this deadly disease and there are many aspects should betake into account to improvise the treatments in lung cancer especially chemotherapy because of the insignificant development in the treatment efficacy in the past few years 8 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, chemotherapy is the only therapeutic option in NSCLC patients, with metastatic stage, although 90% of the cases end in death as they cannot be cured via surgery. 7 Alternative strategies are required to circumvent this deadly disease and there are many aspects should betake into account to improvise the treatments in lung cancer especially chemotherapy because of the insignificant development in the treatment efficacy in the past few years. 8 Chemotherapy comprise of both synthetic and natural compound to decrease or halt the development and migration of cancer cells.…”

mentioning

confidence: 99%

Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway

Yin

Yang

Guo

et al. 2021

Environmental Toxicology

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This work focuses on evaluating the therapeutic ability of betalain and its causal mechanisms in NSCLC both in vivo and in vitro. The experimental results demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells. Betalain also augmented the apoptotic cells of A549 and cell cycle arrest which was evidenced via increased in level of p53/p21 and decreasing levels of cyclin-D1 complex. Moreover, betalain also reduced the levels of p-PI3K, p-Akt, and mammalian target of rapamycin significantly, justifying the pro-apoptotic effect on A549 cells. The in vivo anticancer activity of betalain was determined further in nude mice injected with A549 cells. Xenograft in vivo experiments confirmed betalain administration of ameliorates the expression of pro-inflammatory cytokines, tumor markers with reduced toxic effect. Accordingly, this combined study provides significant insight on betalain as a therapeutic agent.

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“…Therefore, it can be summed up that nanotechnology plays a vital role in the improvement of safety, patient compliance, efficacy and drug shelf life. 7 Despite various novel innovations for the delivery of dynamic pharmacotherapeutic mixes, drug formulation through the oral route is viewed as the most common for patients of all ages. 8 The high-dose requirements of some drugs have intensified the need to design nano-enabled drug delivery systems (DDSs), which have many benefits over conventional DDSs.…”

Section: Introductionmentioning

confidence: 99%

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

Verma¹,

Kaushik²,

Almeer³

et al. 2021

IJN

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The purpose of this proposed research was to investigate a nano-formulation developed using self-nanoemulsifying drug delivery system (SNEDDS) to improve the pharmacodynamic potential of rosuvastatin by assisting its transportation through lymphatic circulation. Methods: The utilized lipids, surfactants, and co-surfactants for SNEDDS were selected on the basis of solubility studies. The SNEDDS formulation was optimized by implementing a D-optimal mixture design, wherein the effect of concentration of Capmul MCM EP (X 1), Tween 20 (X 2) and Transcutol P (X 3) as independent variables was studied on droplet size (Y 1), % cumulative drug release (Y 2) and self-emulsification time (Y 3) as dependent variables. The optimized formulation was evaluated via in vitro parameters and in vivo pharmacodynamic potential in Wistar rats. Results: The D-optimal mixture design and subsequent ANOVA application resulted in the assortment of the optimized SNEDDS formulation that exhibited a droplet size of nano range (14.91nm), in vitro drug release of >90% within 30 minutes, and self-emulsification time of 16 seconds. The in vivo pharmacodynamic study carried out using Wistar rats confirmed the better antihyperlipidemic potential of developed formulation in normalizing the lipidic level of serum in contrast to pure drug and marketed tablets. Conclusion: This research reports the application of D-optimal mixture design for successful and systematic development of rosuvastatin-loaded SNEDDS with distinctly enhanced in vitro and in vivo performance in comparison to marketed formulation. Eventually, improved anti-hyperlipidemic efficacy was envisaged which might be attributed to increased drug solubility and absorption. Overall, this study shows the utility of SNEDDS for improving the dissolution rate and bioavailability of poor aqueous-soluble drugs. The present SNEDDS formulation could be a promising approach and alternative to conventional dosage form.

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Drug Delivery Systems of Natural Products in Oncology

Cited by 58 publications

References 171 publications

Anticancer Molecular Mechanism of Protocatechuic Acid Loaded on Folate Coated Functionalized Graphene Oxide Nanocomposite Delivery System in Human Hepatocellular Carcinoma

Anticancer Molecular Mechanism of Protocatechuic Acid Loaded on Folate Coated Functionalized Graphene Oxide Nanocomposite Delivery System in Human Hepatocellular Carcinoma

Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

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