Drug development against tuberculosis: Impact of alkaloids

Mishra, Shardendu; Tripathi, G.; Kishore, N.; Singh, Rakesh Kumar; Singh, Archana; Tiwari, Vinod K.

doi:10.1016/j.ejmech.2017.06.005

Cited by 52 publications

(22 citation statements)

References 327 publications

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“…Recently, Isaka and coworkers [ 44 , 45 ] reported a potent antitubercular activity of several lanostane triterpenoids isolated from different cultures of Ganoderma species with MIC values ranging between 0.78 and 12.5 μ g/ml. In addition, a lot of isolated alkaloids belonging to various classes, e.g., indole, pyrrole, indoloquinoline, carbazole, manzamine, quinoline, isoquinoline, and pyrrolidine alkaloids were investigated for their antimycobacterial activities against M. tuberculosis , where many of them exhibited a notable and potent efficacy and may be regarded as lead molecules for the treatment of tuberculosis [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Alajmi

Mothana

Al‐Rehaily

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Tuberculosis (TB) remains a common deadly infectious disease and worldwide a major health problem. The current study was therefore designed to investigate the in vitro antimycobacterial activity of different extracts of Alpinia galanga and Tinospora cordifolia. Moreover, a safety assessment for both plants was carried out. Dichloromethane and ethanolic extracts of each plant were examined against H37Rv INH-sensitive and resistant INH strains of Mycobacterium tuberculosis. The safety assessment of both plants has been performed through in vivo acute and chronic toxicity studies in animal model. Body weight, food consumption, water intake, organ's weight, and haematological and biochemical parameters of blood and serum were evaluated. The extracts of A. galanga and T. cordifolia produced significant and dose-dependent inhibitory activity with maximum effect of 18-32% at 50 μg/ml against both strains of M. tuberculosis. No effect on the body weight or food and water consumption was observed but A. galanga caused significantly an increase in the relative weight of the heart, liver, spleen, and kidney. Haematological studies of both plants revealed a slight but significant fall in the RBC and WBC level as well as haemoglobin and platelets. In addition, A. galanga extracts increased significantly liver enzymes and bilirubin and glucose.

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Section: Discussionmentioning

confidence: 99%

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Alajmi

Mothana

Al‐Rehaily

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Benzylsulfoxide derivatives are the most privileged scaffolds in natural biological products [1], pharmaceutical chemistry [2], and functionalized materials [3]. In particular, benzylsulfoxide derivatives exhibit a wide range of biological properties, such as anti-bacterial activity (Scheme 1I) [4], anti-cancer activity (Scheme 1II) [5], and HIV inhibition (Scheme 1III) [6]. The most common synthetic method for benzylsulfoxide derivatives is sulfide oxidation, as illustrated in Scheme 2A [7].…”

Section: Introductionmentioning

confidence: 99%

Direct Sulfoxidation of Aromatic Methyl Thioethers with Aryl Halides by Copper-Catalyzed C(sp3)–H Bond Activation

Xu¹,

Zhu²,

Xiong³

et al. 2019

Catalysts

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“…Tuberculosis (TB) can be considered a global public health threat due to the fact that it is a leading killer of adults in the world today. TB incidence is aggravated by the HIV co-infection and emergence of drug-resistant strains such as multi drug resistance (MDR) and extremely drug resistance (XDR) tuberculosis [1], [2]. In 2012, 450,000 individuals developed MDR-TB globally, and 170,000 deaths were reported from it [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Anitimycobacterial activity and potential mechanism of action of Campnosperma auriculatum shoot extract

Sanusi

Bakar

Mohamed

et al. 2018

AIP Conference Proceedings

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Tuberculosis (TB) is a great public health challenge and a number one cause of morbidity and mortality worldwide. Around one-third of the global populations are latently infected with TB. C. auriculatum is medicinal plant used by the Jakun tribe of Endau Romping, Johor, Malaysia in the treatment of coughing with blood (hemoptysis). C. auriculatum shoot was collected from Taman Negara Johor Endau Rompin, Mersing, Johor, and extracted with hexane, ethyl acetate, methanol, and water. The antimycobacterial activity of the C. auriculatum shoot extracts was tested against Mycobacterium smegmatis mc 2 155 (ATCC 700084) using broth microdilution assay technique to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The cells of M. smegmatis were exposed to most active extract, and then time-kill assay and scanning electron microscopy were carried out to investigate the effect on cell growth and morphology. Gas Chromatography-Mass Spectrometry (GC-MS) was used to investigate the compound present extract. The methanol extract exhibited the best antimycobacterial activity against M. smegmatis with the MIC and MBC values of 1.56 and 3.13 mg/mL respectively. The methanol extract resulted in a significant reduction of colony counts. Furthermore, the appeared elongated, filamentous, swollen with lesions, and there was the appearance of small globular debris. Five compounds were identified with 1-Methyl-trans-decahydroquinol-5(equat)-ol (80.32%) been dominant. The results demonstrated that C. auriculatum have a great potential in TB-drug research if further investigated.

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Drug development against tuberculosis: Impact of alkaloids

Cited by 52 publications

References 327 publications

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Direct Sulfoxidation of Aromatic Methyl Thioethers with Aryl Halides by Copper-Catalyzed C(sp3)–H Bond Activation

Anitimycobacterial activity and potential mechanism of action of Campnosperma auriculatum shoot extract

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