Drug discovery for alopecia: gone today, hair tomorrow

Santos, Zenildo; Avci, Pinar; Hamblin, Michael R.

doi:10.1517/17460441.2015.1009892

Cited by 97 publications

(79 citation statements)

References 172 publications

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“…Stem-cell therapy in alopecia 6.1. Hair follicle, stem cells, and dermal papilla Hair follicle (HF) is a complex structure that contains important units in the development of hair shaft including dermal papilla, matrix, and bulge region [3].…”

Section: Alopecia Areatamentioning

confidence: 99%

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Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet-rich plasma, low-level light therapy, and stem-cell therapy with variable outcomes are reviewed in this chapter.

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Section: Alopecia Areatamentioning

confidence: 99%

“…The signaling in this cycling is not completely understood. Fundamentally, there is a bidirectional communication between the mesenchymal and stem cells within the hair follicle that controls the formation, growth, and cycling of hair follicle [3,116,117].…”

Section: Alopecia Areatamentioning

confidence: 99%

Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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“…8 However, clinical features of PCIA seem strikingly similar to that of severe AGA. 5 The histological picture of taxane-related permanent alopecia is consistent in all published reports.…”

Section: Discussionmentioning

confidence: 96%

“…Currently, however, it seems that chemotherapeutic agents share proapoptotic pathways (mainly mediated by p53) that selectively target growing cells, and consequently prominently affect the highly proliferative hair-matrix keratinocytes of anagen hair follicles. 7,8 This leads to hair-cycle abnormalities, often reversible within 6 weeks after cessation of chemotherapy. Hair follicle epithelial stem cells are a vital progenitor for epithelial lineages within the follicle.…”

Section: Discussionmentioning

confidence: 99%

Alopécia Permanente Pós-Quimioterapia com Resposta Favorável ao Minoxidil Tópico

Pires

Pinheiro

Lencastre

2018

SPDV

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RESUMO -A alopécia permanente pós-quimioterapia é um efeito adverso raro, classicamente associada a altas doses de quimioterapia sistémica com busulfan para transplante de medula óssea. Recentemente têm sido descritos casos de alopécia permanente pós-quimioterapia em doentes submetidos a quimioterapia sistémica com taxanos no carcinoma da mama. Na revisão da literatura não existem orientações terapêuticas consistentes para esta entidade com impacto importante na qualidade de vida dos doentes. Descreve-se o caso de uma doente de 38 anos que desenvolveu alopecia inaugural e permanente após quimioterapia com taxanos (docetaxel) para carcinoma da mama, com 2 anos de evolução à data da observação. Após 6 meses de tratamento tópico com solução de minoxidil 5%, em regime bidiário, assistiu-se a resposta clínica favorável. Os autores revêm o provável mecanismo patológico da alopécia permanente pós-quimioterapia, bem como os efeitos do minoxidil tópico no ciclo do cabelo, por forma a sustentar este fármaco como opção terapêutica a considerar neste tipo de alopecia. PALAVRAS-CHAVE -Alopecia/induzida quimicamente; Alopecia/tratamento Minoxidil; Taxanos. Case of Permanent Chemotherapy-Induced Alopecia with Response to Topical Minoxidil ABSTRACT -Permanent chemotherapy-induced alopecia is uncommon and has primarily been reported after high-dose busulfan

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“…[1][2][3] Microinflammation has been postulated to be involved. [4,5] Yet, exploratory molecular work in patients is difficult.…”

Section: Introductionmentioning

confidence: 99%

Infundibular protein and RNA microarray analyses from affected and clinically non‐affected scalp in male androgenetic alopecia patients

Vogt

Pfannes

Fimmel

et al. 2017

Experimental Dermatology

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Non-invasive sample collection methods could facilitate clinical research on hair diseases. In an exploratory experimental study on six male volunteers with untreated androgenetic alopecia (AGA), Hamilton-Norwood stage IIIv-IV, skin surface and infundibular protein as well as RNA extracts from plucked hair follicles were analyzed from frontal skin, vertex and clinically unaffected occiput. Slightly increased levels of inflammatory markers were only found in AGAaffected scalp skin and infundibulum, not in RNA from plucked hair follicles. RNA expression profiles point towards differential expression of genes involved in hair cycle regulation, hair keratin production, but also RNA methylation and ion channel regulation. | BACKGROUNDOur current concept of androgenetic alopecia (AGA) suggests that different factors including hormonal effects, ion channel regulation, vascularization, and prostaglandins contribute to the disease onset and progression. [1][2][3] Microinflammation has been postulated to be involved. [4,5] Yet, exploratory molecular work in patients is difficult.Clinical trials largely rely on macroscopic readouts. Inclusion of biomarkers usually requires skin biopsies, limiting the number of investigational sites and frequency of sampling. Non-invasive sample collection methods could help increase our understanding of hair growth regulation. | QUESTIONS ADDRESSEDIn this pilot study, we combined clinical diagnostics with a new method for non-invasive sampling of infundibular protein [6] and RNA microarray analysis of plucked hair follicles to investigate inflammatory processes in AGA-affected scalp skin. Additionally, we looked into gene expression to identify new markers of relevance in androgenetic alopecia. | EXPERIMENTAL DESIGNSix male volunteers with untreated AGA, Hamilton-Norwood stage IIIv-IV, were included. Investigational sites (frontotemporal area, vertex, clinically unaffected occiput) were assessed (Table S1) by phototrichogram analysis, sebum and pH determination, optical coherence tomography (OCT), ultrasonography, hair root plucking (trichogram, Figure S1) and mini-zone cyanoacrylate skin surface stripping (CSSS).[6] Seborrhoeic dermatitis was an exclusion criterion.RNA from about 30 hairs from each site was obtained by hair plucking and extraction performed using RNeasy kit (Qiagen, Hilden, Germany). For hybridization, Agilent Gene Expression Hybridization kit (Agilent Technologies Inc., Santa Clara, CA, USA) was used, andCy3-labelled fragmented cRNA hybridized overnight to Agilent WholeHuman Genome Oligo Microarrays 8 × 60 K V2 using Agilent's recommended hybridization chamber and oven. The Agilent FeatureExtraction software was used to read out and process the microarray image files. Data were normalized followed by correlation analysis and differential gene expression analysis (DGA). For further details concerning study plan, methods and the microarray data, please refer to the Appendix S1. | RESULTSConsistent with the clinical diagnosis, the total hair density was significantl...

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Drug discovery for alopecia: gone today, hair tomorrow

Cited by 97 publications

References 172 publications

Cosmetic Procedures in the Treatment of Alopecia

Cosmetic Procedures in the Treatment of Alopecia

Alopécia Permanente Pós-Quimioterapia com Resposta Favorável ao Minoxidil Tópico

Infundibular protein and RNA microarray analyses from affected and clinically non‐affected scalp in male androgenetic alopecia patients

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