Drug dispersion for single- and multi-lumen catheters

Schwalbach, Dillon; Plourde, Brian D.; Abraham, John; Kohler, Robert Ε.

doi:10.4236/jbise.2013.611127

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…There, an illustration of the multi-lumen catheter is provided. This catheter is termed the ND ® Infusion Catheter which was also subject to prior published research [36][37][38].…”

Section: Methodsmentioning

confidence: 99%

A New Catheter Technology to Deliver Vascular Stem-Cells

Plourde¹,

Stark²,

Abraham³

2016

Stud Stem Cells Res Ther

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A new device has been designed, developed and tested to improve the capacity of vascular drug and stem cell delivery. The device consists of a catheter with a multitude of small lumens (instead of a large central channel lumen). The use of multiple lumens provides a number of benefi ts to medical intervention. First, the multiple lumens are spread across the catheter cross section. As a consequence, the medication/stem cells are more effectively dispersed into the artery. Second, the construction of the new catheter has an increased mechanical strength compared to the standard single-lumen cathetertherefore, it is able to resist compressive forces caused by a pressurized balloon. This fact makes the new design able to preserve medication/stem cell fl owrates without causing mechanical hemolysis to the cells. Finally, the newly designed device prohibits clumping of stem cells carried in solution.

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“…There, an illustration of the multi-lumen catheter is provided. This catheter is termed the ND ® Infusion Catheter which was also subject to prior published research [36][37][38].…”

Section: Methodsmentioning

confidence: 99%

A New Catheter Technology to Deliver Vascular Stem-Cells

Plourde¹,

Stark²,

Abraham³

2016

Stud Stem Cells Res Ther

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“…Over the past few years, the focus has moved toward patient-specific modeling with a goal of identifying those features of the flow that are predictive of aneurysm growth and rupture. In addition to the evolution of aneurysms, flow dynamics are important for predicting transport processes which occur within the artery wall [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Impacts of waveforms on the fluid flow, wall shear stress, and flow distribution in cerebral aneurysms and the development of a universal reduced pressure

Naughton¹,

Plourde²,

Stark³

et al. 2014

JBiSE

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The hydrodynamics of aneurysm blood flow is thought to be a critical factor in the evolution and potential rupture of blood vessel walls. The ability to predict which aneurysms may grow or rupture has eluded researchers and practicing clinicians. On the other hand, it is expected that local flow patterns, pressures, and wall shear stress play a role in the aneurysm life. In this study, the impact of waveform on these parameters was studied. A baseline waveform, taken from a patient, was applied to an aneurysm geometry. Then the waveform was modified by increasing and decreasing both the flowrates and the cardiac rate. In total, seven cases were investigated. It was found that there were remarkable similarities in the patterns of flow and wall stresses for the cases. These similarities existed throughout the cardiac cycle. It was also found that there was a reduced pressure variable that provides a universal relationship that characterizes all of the cases. It was seen that the maximum wall shear occurs at the neck of the aneurysm and scales with the peak systolic velocity. Finally, it is shown that the flow distribution to the multiple outlets does not appreciably depend on the details of the inlet waveform. All cases had a flow distribution that was within 2%.

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Impact of Balloon Inflation Pressure on Cell Viability with Single and Multi Lumen Catheters

Dib¹,

Schwalbach

Plourde

et al. 2014

J. of Cardiovasc. Trans. Res.

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Infusion catheters, when used in combination with balloons, are subjected to pressure created by inflation of the balloon. The compression can reduce the catheter flow area and cause elevated shear stresses in the fluid. A model and experiments were developed with a range of applied balloon pressures to investigate whether such situations may cause cell lysis during stem-cell infusion through single-lumen catheters. It was found that for balloon inflation pressures in excess of ~7 atm, it is possible for cell injury to occur, although the critical pressure depends on the fluid viscosity. The study was then applied to a multi-lumen catheter which was designed to resist compression. That device was able to handle very elevated balloon pressures and flow rates before cell lysis became a concern.

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Drug dispersion for single- and multi-lumen catheters

Cited by 5 publications

References 19 publications

A New Catheter Technology to Deliver Vascular Stem-Cells

A New Catheter Technology to Deliver Vascular Stem-Cells

Impacts of waveforms on the fluid flow, wall shear stress, and flow distribution in cerebral aneurysms and the development of a universal reduced pressure

Impact of Balloon Inflation Pressure on Cell Viability with Single and Multi Lumen Catheters

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