Drug-Eluting Coronary-Artery Stents

doi:10.1056/nejmc1301999

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…Yang et al developed a nanotubular titanium oxide (TiO 2 ) system containing the thrombin inhibitor bivalirudin (BVLD), which remained stable on the polydopamine-coated surfaces for at least two months. These substrates largely inhibited thrombin activity and platelet adhesion while enhancing HUVEC adhesion and growth . The above studies denote polydopamine’s contribution to the biocompatibility of implanted materials, which could expand their usage in translational endeavors.…”

Section: Applications In Tissue Engineeringmentioning

confidence: 99%

Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications

et al. 2015

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Current advances in biomaterial fabrication techniques have broadened their application in different realms of biomedical engineering, spanning from drug delivery to tissue engineering. The success of biomaterials depends highly on the ability to modulate cell and tissue responses, including cell adhesion, as well as induction of repair and immune processes. Thus, most recent approaches in the field have concentrated on functionalizing biomaterials with different biomolecules intended to evoke cell- and tissue-specific reactions. Marine mussels produce mussel adhesive proteins (MAPs), which help them strongly attach to different surfaces, even under wet conditions in the ocean. Inspired by mussel adhesiveness, scientists discovered that dopamine undergoes self-polymerization at alkaline conditions. This reaction provides a universal coating for metals, polymers, and ceramics, regardless of their chemical and physical properties. Furthermore, this polymerized layer is enriched with catechol groups that enable immobilization of primary amine or thiol-based biomolecules via a simple dipping process. Herein, this review explores the versatile surface modification techniques that have recently been exploited in tissue engineering and summarizes polydopamine polymerization mechanisms, coating process parameters, and effects on substrate properties. A brief discussion of polydopamine-based reactions in the context of engineering various tissue types, including bone, blood vessels, cartilage, nerves, and muscle, is also provided.

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Section: Applications In Tissue Engineeringmentioning

confidence: 99%

Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications

et al. 2015

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“…With bare-metal stents (BMS), the incidence of ISR was as high as 20–40% [12,13], and with drug-eluting stent (DES), the incidence still remained about 10% [14–17]. It is generally believed that ISR is one of the most important prognostic factors after PCI and is also one of the major difficulties in CHD treatment [18,19].…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Heart Disease: A Clinical Trial Based on 1-Year Follow-Up

et al. 2019

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BackgroundThis study observed the incidence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) and discusses the risk factors of ISR based on clinical data, coronary angiography, and stent features, to provide a theoretical basis for the prevention and treatment of ISR.Material/MethodsWe selected 1132 cases who received stent implantation at the Shaanxi People’s Hospital from June 2014 to June 2016 and were followed up by coronary angiography within 1 year. Based on coronary angiography, the cases were divided into ISR and non-ISR groups. ISR was defined as a reduction in lumen diameter by over 50% after PCI. The ISR group consisted of 93 cases and the non-ISR group consisted of 1039 cases. Medical history, biochemical indicators, features of coronary artery lesions, and stent status were analyzed retrospectively. Risk factors of ISR were identified by univariate and multivariate logistic regression analyses.ResultsAmong 1132 cases, 93 cases had ISR, with the overall incidence of 8.21%. Univariate and multivariate logistic regression analyses indicated that postoperative hypersensitive C-reactive protein (hs-CRP) levels (OR=2.309, 1.579–3.375 mg/L), postoperative homocysteine (HCY) levels (OR=2.202, 1.268–3.826 μmol/L), history of diabetes (OR=1.955,1.272–3.003), coronary bifurcation lesions (OR=3.785, 2.246–6.377), and stent length (OR=1.269, 1.179–1.365 mm) were independent risk factors of ISR after PCI (P<0.05).ConclusionsElevated hs-CRP and HCY levels after PCI, history of diabetes, coronary bifurcation lesions, and greater stent length were associated with a higher risk of ISR. Patients with a higher risk of ISR should receive routine follow-up and intense medication management after PCI to control the risk factors and to reduce ISR.

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“…Coronary artery disease (CAD), a major threat to human health, has become one of the leading causes of disease and death worldwide. , Currently, drug-eluting stents (DES) are widely used to restore blood flow. , However, there is a risk of restenosis, delayed endothelial healing, and late thrombosis after stent implantation. − The ideal stent should have the surface characteristics of inhibiting intimal hyperplasia, good blood compatibility, and accelerating endothelialization. , However, many drug stents currently contain only small amounts of single drugs or biological molecules, which cannot meet the treatment requirements of complexity of the disease. − Thus, the strategy of modifying DES by combining two or more biomolecules with different functions and utilizing their synergistic effects are becoming more interesting. − …”

Section: Introductionmentioning

confidence: 99%

“…1,2 Currently, drug-eluting stents (DES) are widely used to restore blood flow. 3,4 However, there is a risk of restenosis, delayed endothelial healing, and late thrombosis after stent implantation. 5−7 The ideal stent should have the surface characteristics of inhibiting intimal hyperplasia, good blood compatibility, and accelerating endothelialization.…”

Section: ■ Introductionmentioning

confidence: 99%

Coronary Stents Decorated by Heparin/NONOate Nanoparticles for Anticoagulant and Endothelialized Effects

et al. 2020

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In the treatment of coronary artery disease (CAD), the use of stent implantation often leads to clinical complications such as restenosis, delayed endothelial healing, and thrombosis. Here, we develop a double drug sustained-release coating for the stent surface by grafting heparin/NONOate nanoparticles (Hep/NONOates). The Hep/NONOates and surface modification of the stent were characterized by X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, static water contact angle, and scanning electron microscopy (SEM), and the release behaviors of the anticoagulant, heparin (Hep) and the bioactive molecule, nitric oxide (NO) were studied. Furthermore, the blood compatibility and cytotoxicity of the modified stent were evaluated by whole blood adhesion and platelet adhesion tests, hemolysis assay, morphological changes of red blood cells, plasma recalcification time assay, in vitro coagulation time tests, and MTT assay. Finally, the results of a rabbit carotid artery stent implantation experiment showed that the double drug sustained-release coating for the stent can accelerate regeneration of endothelial cells and keep good anticoagulant activity. This study can provide new design ideas based on nanotechnology for improving the safety and effectiveness of drug-eluting stents.

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Drug-Eluting Coronary-Artery Stents

Cited by 7 publications

References 37 publications

Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications

Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications

Factors Influencing Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Heart Disease: A Clinical Trial Based on 1-Year Follow-Up

Coronary Stents Decorated by Heparin/NONOate Nanoparticles for Anticoagulant and Endothelialized Effects

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