2020
DOI: 10.1038/s41598-020-71129-0
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Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Abstract: Triple-negative breast cancer (TNBC) is more aggressive and difficult to treat using conventional bulk chemotherapy that is often associated with increased toxicity and side effects. In this study, we encapsulated targeted drugs [A bacteria-synthesized anticancer drug (prodigiosin) and paclitaxel] using single solvent evaporation technique with a blend of FDA-approved poly lactic-co-glycolic acid-polyethylene glycol (PLGA_PEG) polymer microspheres. These drugs were functionalized with Luteinizing Hormone-Relea… Show more

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Cited by 80 publications
(72 citation statements)
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References 89 publications
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“…The effect of the surfactant observed in this study is consistent with the findings of our prior work on the encapsulation of prodigiosin in electrospun fibers. 16 Although the proportion of the encapsulated prodigiosin (PG) released from the pluronic F127-containing fibers was similar (i.e., 50%) under the same sink conditions at physiological temperature and pH, a lower percentage of prodigiosin (PG) was released from the non-pluronic F127 fibers than in this study (80% vs. 90%). This suggests that the surfactant exerts similar stabilizing effects on the fibers (PLGA/Ge) and drugs (AME and PG) to prolong their release, whereas, in the absence of the surfactant, the AME extract and PG drug exhibit different diffusion rates out of the fibers.…”
Section: Release Profile and Kinetics Of Ame Extracts From The Ame-loaded Scaffoldscontrasting
confidence: 51%
See 1 more Smart Citation
“…The effect of the surfactant observed in this study is consistent with the findings of our prior work on the encapsulation of prodigiosin in electrospun fibers. 16 Although the proportion of the encapsulated prodigiosin (PG) released from the pluronic F127-containing fibers was similar (i.e., 50%) under the same sink conditions at physiological temperature and pH, a lower percentage of prodigiosin (PG) was released from the non-pluronic F127 fibers than in this study (80% vs. 90%). This suggests that the surfactant exerts similar stabilizing effects on the fibers (PLGA/Ge) and drugs (AME and PG) to prolong their release, whereas, in the absence of the surfactant, the AME extract and PG drug exhibit different diffusion rates out of the fibers.…”
Section: Release Profile and Kinetics Of Ame Extracts From The Ame-loaded Scaffoldscontrasting
confidence: 51%
“…13 Prior works have also explored the development of sustainedrelease drug delivery systems in an attempt to maintain and localize the anticancer drug concentrations at desirable doses over longer durations than bulk systemic chemotherapy to maximize therapeutic effect. [14][15][16] A few researchers have reported the successful loading of AME extracts into drug delivery carriers to potentiate their cytotoxic effects through their sustained release to the target cells. [17][18][19] For instance, Aruan et al 17 incorporated AME leaf extracts into electrospun polyvinyl alcohol nanofiber scaffolds and demonstrated the cytotoxic effects of the released extracts on the growth of Staphylococcus aureus.…”
Section: Introductionmentioning
confidence: 99%
“…To overcome its short half-life, PLGA is combined with polyethylene glycol (PEG) to form PLGA-PEG copolymer NPs [63][64][65]. The PLGA-PEG copolymer is widely used in pharmaceutical products and devices.…”
Section: Plga-peg Co-polymeric Nps Modifications and Applicationsmentioning
confidence: 99%
“…This study employed FTIR to characterize the chemical bonds/functional groups on SF-film that were relevant to the physicochemical properties and drug-loading capabilities of the film [43]. This study did not observe significant wavenumber shifts in the SF-…”
Section: Manufacturing Procedures Of Silk Fibroin (Sf)-filmmentioning
confidence: 99%