Drug-induced acne

Kazandjieva, Jana; Tsankov, Nikolaï

doi:10.1016/j.clindermatol.2016.10.007

Cited by 63 publications

(53 citation statements)

References 51 publications

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“…32 Presently, the list of drugs that causes acne is increasing with the newer drugs, especially chemotherapeutic agents that are being added every year. 33 Urticaria was observed in 6.89% and FDE in 5.6% of the reported cases in the present study. As observed for maculopapular rash, antimicrobial agents were the commonest cause for both urticaria and FDE followed by NSAIDs.…”

Section: Discussionsupporting

confidence: 47%

Analysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South India

Konda

Pilla

Surekha

et al. 2018

Int J Basic Clin Pharmacol

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Background: Skin is the most common organ involved in adverse reactions due to drugs. With newer drugs released into market every year, there is changing pattern of the reported cutaneous adverse drug reactions (ADRs). In order to ensure safer use of medicines in patients, there is need for continuous monitoring of ADRs. This is a retrospective study to analyse spontaneously reported cutaneous ADRs.Methods: All the cutaneous ADRs reported between January 2017 and September 2018 were analysed for clinical patterns, suspected medications, causality, severity and preventability.Results: Of the 1035 reports received during the study period, 232 (22.41%) included cutaneous reactions. 113 (48.7%) were male and 119 (51.29%) were female. Maculopapular rash 70 (30.17%), pruritus 31 (13.36%), palmar plantar erythrodysesthesia 30 (12.93%), acne 19 (8.19%), urticaria 16 (6.89%) and fixed drug eruptions (FDE) 13 (5.6%) were the common clinical patterns. Antimicrobial agents followed by anticancer drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), hormones and related drugs, and antiepileptic drugs were the common suspected group of drugs. Causality assessment as done by WHO-UMC scale showed that 3 (1.29%) were certainly related, 174 (75%) were probably related and 55 (23.7%) were possibly related to the suspected medication.Conclusions: Cutaneous ADRs are most frequently reported ADRs in the present study. With newer drugs released into market, there is a need for continuous monitoring of use of drugs to promote safer use of medicines in patients.

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Section: Discussionsupporting

confidence: 47%

Analysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South India

Konda

Pilla

Surekha

et al. 2018

Int J Basic Clin Pharmacol

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“…Corticosteroids, halogens, isoniazid, lithium, vitamin B12, immunosuppressants and certain anticancer agents and radiotherapy have been reported causing acneiform eruptions. [59][60][61][62][63][64][65][66][67][68][69][70] We consider these dermatoses as a differential diagnosis of acne.…”

Section: Acne Exposome Factorsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

122

110

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Background Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.AimTo assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.MethodsTwo consensus meetings of five European dermatologists and a comprehensive literature search on exposome factors triggering acne served as a basis for this review.ResultsAcne exposome was defined as the sum of all environmental factors influencing the occurrence, duration and severity of acne. Exposome factors impact on the response and the frequency of relapse to treatments by interacting with the skin barrier, sebaceous gland, innate immunity and cutaneous microbiota. They may be classified into the following six main categories: nutrition, psychological and lifestyle factors, occupational factors including cosmetics, as well as pollutants, medication and climatic factors. Moreover, practical considerations for the dermatologist's clinical practice are proposed.ConclusionExposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.

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“…In contrast, it should be expected that p450-inducing agents such as isoniazid, phenobarbital, rifampicin, phenytoin, glucocorticosteroids and others [ 95 – 97 ] may lower intracellular ATRA levels and thus increase the risk for acne. Indeed, the majority of drugs reported to promote acne and acneiform drug eruption are p450-inducing agents [ 98 – 100 ].…”

Section: Tetracyclines and Macrolidesmentioning

confidence: 99%

p53: key conductor of all anti-acne therapies

Melnik

2017

J Transl Med

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This review based on translational research predicts that the transcription factor p53 is the key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis retinoic acid) enhance p53 expression. Tetracyclines and macrolides via inhibiting p450 enzymes attenuate ATRA degradation, thereby increase p53. Benzoyl peroxide and hydrogen peroxide elicit oxidative stress, which upregulates p53. Azelaic acid leads to mitochondrial damage associated with increased release of reactive oxygen species inducing p53. p53 inhibits the expression of androgen receptor and IGF-1 receptor, and induces the expression of IGF binding protein 3. p53 induces FoxO1, FoxO3, p21 and sestrin 1, sestrin 2, and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), the key inducer of isotretinoin-mediated sebocyte apoptosis explaining isotretinoin’s sebum-suppressive effect. Anti-androgens attenuate the expression of miRNA-125b, a key negative regulator of p53. It can thus be concluded that all anti-acne therapies have a common mode of action, i.e., upregulation of the guardian of the genome p53. Immortalized p53-inactivated sebocyte cultures are unfortunate models for studying acne pathogenesis and treatment.

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Drug-induced acne

Cited by 63 publications

References 51 publications

Analysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South India

Analysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South India

The influence of exposome on acne

p53: key conductor of all anti-acne therapies

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