Drug-Induced Effects on Reticular Groove Reflex, Eructation and Rumination

Ooms, L.; Degryse, Anne‐Dominique; Weyns, A.; Bouisset, Simon; Ruckebusch, Y.

doi:10.1007/978-94-009-3319-4_11

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…The present findings confirm earlier reports that a-adrenergic blockade does not significantly affect the extrinsically regulated resting contractions of the reticulo-rumen (Leek & van Miert, 1971;Toutain et al, 1982;Ruckebusch, 1983;Ruckebusch & Toutain, 1984).…”

Section: Discussionsupporting

confidence: 93%

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Inhibition of rumination in sheep by α‐adrenoreceptor antagonists

Nicholson

Osman

Belkhiri

1988

Vet Pharm & Therapeutics

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Rumination activity was recorded in sheep during a period of 3 h. The amount of rumination occurring in 30 min following the intravenous injection of an alpha 1 blocking drug (prazosin, 0.1 mg/kg) and an alpha 2 blocking drug (idazoxan, 0.1 mg/kg) was reduced compared with control days when saline was given. The observation that rumination can be stimulated by a rapid, intravenous dose of adrenalin was confirmed. The induction of rumination by adrenalin was prevented by these alpha-adrenoreceptor antagonists given singly or together at the dose rate mentioned. These findings are discussed in the light of knowledge that normal reticulo-ruminal motility and food intake can be inhibited by stimulation of alpha 2-adrenoreceptors.

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Section: Discussionsupporting

confidence: 93%

“…The dose of the specific al blocker, prazosin, was 0.1 mg/kg. This was between the dose of 0.06 mg/kg which Ruckebusch (1983) Idazoxan was prepared freshly by dissolving the dose required in 10 ml of sterile saline. This volume was injected in 1 min.…”

Section: Drugsmentioning

confidence: 99%

Inhibition of rumination in sheep by α‐adrenoreceptor antagonists

Nicholson

Osman

Belkhiri

1988

Vet Pharm & Therapeutics

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“…Adrenalin evoked rumination in sheep when injected intrajugularly (Kay, 1959) by acting upon a2-adrenoreceptors (Leek & Stafford, 1987a) located in the forestomach (Leek & Stafford, 1986). Dopamine also induced rumination when given intrajugularly, especially when preceded by an injection of naloxone (Ooms et al, 1987) or by the dopaminergic antagonists domperidone or metoclopramide (Bueno et al, 1983). Dopamine injected intracerebroventricularly also evoked rumination in sheep.…”

Section: Introductionmentioning

confidence: 95%

Dopamine‐sensitive receptors that evoke rumination and modify reticulo‐ruminal activity in sheep

Stafford

Leek

1988

Vet Pharm & Therapeutics

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Dopamine (20 micrograms/kg) evoked rumination in sheep when injected as a bolus into the coeliac artery or into the left gastric artery but not when injected into the carotid artery. A mixed alpha-adrenoreceptor antagonist (phentolamine) and an alpha 2-adrenoreceptor antagonist (yohimbine) prevented dopamine from evoking rumination, but a dopaminergic antagonist (metoclopramide) did not. These findings suggest that dopamine stimulated rumination by acting upon alpha 2-adrenoreceptors situated in the area supplied by the left gastric artery, whereas dopamine injected intracerebrally may have evoked rumination by an alpha 2-adrenoreceptor effect in the central nervous system (Bueno et al., 1983) and the actions of intrajugular dopamine were exclusively upon peripheral adrenoreceptors located specifically in the gastric area. Dopamine (1 microgram/kg/min) infused into the carotid artery reduced the frequency of reticular contractions by acting upon a centrally located dopaminergic receptor mechanism sensitive to metoclopramide but not to phentolamine. When dopamine was infused into the coeliac artery or into the left gastric artery, the amplitude of reticular contractions was reduced by a peripheral mechanism sensitive both to metoclopramide and to phentolamine. Dopamine also reduced the amplitude of reticular contractions when infused into the carotid artery but to a lesser degree than when given into the coeliac or left gastric artery.

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“…Reflex inhibition can also be interesting in some practices with sheep. Inhibition can be achieved administering a local anaesthetic in the oral cavity, with atropine intravenous injections, acting at the level of the efferent pathway (12,60) and with metoclopramide (0.2 mg/kg) (61) which act as an antagonist of dopamine through the cholinergic system. Domperidone has a similar effect although not with the same access intensity in CNS that metoclopramide (62) .…”

Section: Reflex Inhibitionmentioning

confidence: 99%

Anatomy, physiology, manipulation and veterinary applications of the reticular groove. Review

MARTÍN-ALONSO

Cal-Pereyra

Fernández-Caso

et al. 2019

Rev. Mex. Cienc. Pecu.

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Reticular groove closure in ruminants is a primary mechanism, almost exclusive of lactating animals, which makes the passage of food from the orifice of cardia to the abomasum possible, thus avoiding unwanted fermentations in rumen and reticulum. In this review It is described some anatomical and physiological aspects of the reticular groove, given its embryonic and postnatal development, its topographic location, structure, innervation, blood circulation and histology. Also describing the techniques used to study its functioning, both direct and indirect methods. Finally there is a concentrate on handling techniques to manipulate closing reflex of reticular groove and its veterinary applications, in both the stimulation and inhibition, since the possibility to control this reflex is of great interest in the oral administration of various drugs, the treatment of certain diseases, as well as a better utilization of some types of food.

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Drug-Induced Effects on Reticular Groove Reflex, Eructation and Rumination

Cited by 6 publications

References 53 publications

Inhibition of rumination in sheep by α‐adrenoreceptor antagonists

Inhibition of rumination in sheep by α‐adrenoreceptor antagonists

Dopamine‐sensitive receptors that evoke rumination and modify reticulo‐ruminal activity in sheep

Anatomy, physiology, manipulation and veterinary applications of the reticular groove. Review

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