Inhibition of rumination in sheep by α‐adrenoreceptor antagonists

Nicholson, T.; Osman, T. E. A.; Belkhiri, M.

doi:10.1111/j.1365-2885.1988.tb00153.x

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…An i.v. injection of adrenaline was shown to increase rumination in sheep (Nicholson et al, 1988), therefore increased rumination performed by HIGH lambs may suggest that transport stimulated a greater sympathetic nervous response in these animals. Alternatively, increased rumination performed by the HIGH group post-transport could be a compensatory effect due to lower pre-transport levels of rumination.…”

Section: Discussionmentioning

confidence: 93%

Effect of pre-slaughter handling, exercise and the presence of a dog on lamb welfare and meat quality

Sutherland

Worth

Stuart

et al. 2016

Animal

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Before slaughter, lambs may experience several stressors such as feed and water deprivation, handling and transport that have the potential to negatively impact welfare and meat quality. The objective of this study was to evaluate the effect of pre-slaughter handling, exercise and the presence of a dog on the behaviour and physiology of lambs and meat quality at slaughter. At 6 months of age, 60 lambs ( n = 20 lambs/replicate; three replicates) were allocated to one of the two treatment groups ( n = 30 lambs/ treatment): low (LOW) intensive handling or high (HIGH) intensive handling. LOW lambs were moved short distances, quietly and without the use of a dog before transport. HIGH lambs were moved quickly, long distances and with a dog present before transport. Lamb behaviour (standing, lying, rumination and panting) was recorded for 1 h before (post-treatment) and after transport (post-transport), and for 30 min before slaughter (pre-slaughter). Blood samples were collected before (baseline), after transport (post-transport) and at exsanguination (at slaughter) to assess cortisol, lactate and non-esterified fatty acid (NEFA) concentrations. At slaughter, lamb carcases ( M. longissimus lumborum) were evaluated for pH levels, drip and cook loss, and tenderness. HIGH lambs spent more time standing ( P < 0.001) and panting ( P < 0.001) and less time lying ( P < 0.001) and ruminating ( P < 0.001) post-treatment than LOW lambs, but more ( P < 0.001) time ruminating post-transport. All lambs spent more time standing ( P < 0.001) and less time lying ( P < 0.001) and panting ( P < 0.001) post-transport and pre-slaughter than post-treatment. Cortisol concentrations were greater ( P < 0.001) in lambs post-transport and at slaughter compared with baseline values. Lactate concentrations were lower ( P = 0.002) in HIGH than LOW lambs. In addition, NEFA concentrations were higher ( P < 0.001) post-transport and at slaughter in HIGH compared with LOW lambs. Ultimate pH was higher ( P < 0.001) in HIGH than LOW lambs and pH declined quicker ( P = 0.012) in LOW than HIGH lambs. Cook loss, drip loss and shear force were lower ( P ⩽ 0.05) in HIGH than LOW lambs. The HIGH intensive pre-slaughter handling regime used in the present study caused stress in lambs and increased ultimate pH that could potentially negatively impact welfare, product quality and consistency.

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Section: Discussionmentioning

confidence: 93%

Effect of pre-slaughter handling, exercise and the presence of a dog on lamb welfare and meat quality

Sutherland

Worth

Stuart

et al. 2016

Animal

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“…Published reports have shown that the adrenergic receptors, located both centrally and it the reticuloruminal wall are involved in the regulation of forestomach motility in ruminants (Ruckebusch, 1983). Many reports indicated that the injection of "-adrenoreceptor antagonists had no significant effects on reticuloruminal motility (Toutain et al, 1982;Nicholson et al, 1988;Nicholson and Osman, 1992). However, at higher doses Toutain et al (1982) noted that phentolamine (0.2 mg kgG 1 ) and prazosin (0.4 mg kgG 1 ) inhibited reticular motility in sheep and Ruckebusch and Toutain (1984) found that reticular motility of cattle was inhibited by tolazoline at 2 mg kgG 1 .…”

Section: Introductionmentioning

confidence: 99%

Role of α-Adrenoreceptors In The Regulation of Fore-Stomach Motility in the Goat

Osman¹,

Al-Busadah²

1999

Pakistan J. of Biological Sciences

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Abstract:The investigation of the effects of intravenous (i.v.) infusion of "2-adrenoreceptor agonists and antagonists on reticuloruminal motility was carried out in conscious goats. The i.v. administration of the "1-agonist phenylephrine (4 µg kgG 1 minG 1 for 15 min) or the "2-agonist naphazoline (2.5 µg kgG 1 minG 1 for 15 min) reduced both frequency and amplitude of reticulum and rumen dorsal sac contractions. Pretreatment of animals with the "1-antagonist prazosin (20 µg kgG 1 minG 1 for 30 min) prevented the inhibitory effects of phenylephrine on reticuloruminal motility. The effects of naphazoline were prevented by yohimbine, an "2-antagonist at 20 µg kgG 1 minG 1 for 30 min. Yohimbine, given alone or followed by naphazoline, abolished secondary ruminal dorsal sac contractions. It is concluded that both "12 and "2-adrenoreceptors are involved in the regulation of reticuloruminal motility in the goat. At the dosage of drugs used al and "2-adrenoreceptors appear to play an inhibitory effect on reticuloruminal motility in the goat.

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Vasopressin inhibits food intake in pygmy goats by activation of α1-adrenergic receptors

Rossi

Scharrer

1994

Pharmacology Biochemistry and Behavior

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Inhibition of rumination in sheep by α‐adrenoreceptor antagonists

Cited by 6 publications

References 12 publications

Effect of pre-slaughter handling, exercise and the presence of a dog on lamb welfare and meat quality

Effect of pre-slaughter handling, exercise and the presence of a dog on lamb welfare and meat quality

Role of α-Adrenoreceptors In The Regulation of Fore-Stomach Motility in the Goat

Vasopressin inhibits food intake in pygmy goats by activation of α1-adrenergic receptors

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