Drug-Induced Gingival Overgrowth

Bontemps, Léa; Gaultier, Fréderick; Anagnostou, Fani; Ejeil, Anne-Laure; Dridi, Sophie-Myriam

doi:10.1007/978-3-030-66973-7_2

Cited by 6 publications

(7 citation statements)

References 54 publications

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“…Bacterial plaque is an important factor, and the severity of gingival overgrowth is directly proportional to the degree of plaque accumulation and plaque-induced inflammation. 11 Surgical treatment of DIGO involves reorganization of the gingiva with a scalpel, blades, or laser. Successful therapeutic management of DIGO includes plaque control, topical folic acid, and topical azithromycin.…”

Section: Discussionmentioning

confidence: 99%

Management of initial and surgical management of amlodipine-induced gingival enlargement with multifactorial etiology: a case report with 6 months follow-up

Akdeniz,

Güler Doğru

2023

JDSE

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Drug-induced gingival enlargement can be seen as a side effect of systemically used drugs such as calcium channel blockers, anticonvulsants, and immunosuppressants. One of these drugs is amlodipine, a dihydropyridine derivative calcium channel blocker used in the treatment of high blood pressure and coronary artery disease. Amlodipine-induced gingival overgrowth is rarely seen compared to other calcium channel blockers. The aim of this case is to present the diagnosis of gingival overgrowth due to amlodipine use and the identification of other etiologic factors such as labial frenulum, phase 1 initial, and phase 2 surgical treatment approaches. A 56-year-old female patient presented to our clinic with severe gingival overgrowth, intense bleeding, difficulty feeding, and pain. The anamnesis revealed that she had hypertension and had been taking amlodipine derivative Norvasc 10 mg once a day for 8 years. A look inside the mouth showed that there was a lot of gum tissue growing over the crowns from the labial and palatal sides, mainly in the front of the maxilla. Phase 1 treatment was initiated. As a result of the consultation with the patient's cardiologist, the hypertension medication Norvasc 10 mg was replaced with Candexil 16 mg by the medical physician. The preoperative tension and blanch test was positive, and the labial frenulum was seen to mobilize the free gingival margin of the central teeth. After the same session of gingivoplasty, the labial frenulum was removed by a frenectomy operation. After the operation, antibiotics, analgesics, and mouthwash were prescribed. The patient stated that he did not have any problems after the operation. 6-month follow-up showed uneventful healing. No recurrence of gingival growth was found in the 1st, 3rd, and 6th month follow-ups. In conclusion, this case report shows that non-surgical periodontal treatment alone isn't always enough to treat drug-induced gingival overgrowths. The gingival shape should be changed so that the patient can properly clean their teeth, and drug-induced gingival overgrowths, like the one in this case, may have more than one cause and may need additional surgery like a labial frenectomy.

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Section: Discussionmentioning

confidence: 99%

Management of initial and surgical management of amlodipine-induced gingival enlargement with multifactorial etiology: a case report with 6 months follow-up

Akdeniz,

Güler Doğru

2023

JDSE

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“…Some children with special health care needs also have epilepsy. Some antiepileptic drugs (such as phenytoin, sodium valproate, phenobarbitone, and vigabatrin) can induce gingival hyperplasia and lead to periodontitis and tooth decay [23][24] . Antipsychotics, such as risperidone, olanzapine, and clozapine, are frequently prescribed to children with ASD, ID, and other neurodevelopmental disorders.…”

Section: E N Ta L H E a Lt H P R O B L E M S A N D M A Na Ge M E N T ...mentioning

confidence: 99%

Preventive Dentistry in Children with Special Needs: Narrative Review

Wannapaschaiyong,

Ketudat,

Bunman

2024

Vajira Med J

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Children with special healthcare needs face a high prevalence of dental and oral health problems due to unique challenges in maintaining oral hygiene. Preventive dentistry, which encompasses practices and strategies aimed at maintaining optimal oral health and preventing dental caries, periodontal disease, and other oral conditions, is therefore of utmost importance for this vulnerable group. This narrative review compiles the dental health concerns commonly encountered in these children and outlines preventive strategies to address them. Common dental issues encountered in this population include dental caries, gingival inflammation, tooth erosion, and attrition. Factors contributing to these problems range from motor impairments limiting brushing ability, food preferences, bruxism, gastroesophageal reflux disease, and side effects of certain medications. Effective preventive measures involve early dental visits, appropriate oral hygiene routines, judicious use of fluoride toothpaste and supplements, dietary modifications, and cessation of nighttime bottle-feeding. Specific recommendations are provided for caregivers, such as selecting the right toothbrush, maintaining proper brushing techniques, and monitoring fluoride intake based on age and risk factors. Interdisciplinary collaboration between pediatricians, dentists, and other healthcare professionals is crucial in identifying potential dental issues and providing tailored preventive care for children with special needs.

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“…However, these medications cause side effects such as gingival overgrowth, which requires regular check-ups with a dentist. 17,18 The objective of this study is to report a clinical case of a patient with nephrotic syndrome as a result of Galloway-Mowat syndrome and who required surgery to remove fibrous gingival tissue to facilitate the eruption of permanent teeth. As it is a rare disease, there are few studies that report oral manifestations in patients affected by this syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…Since these patients usually undergo kidney transplantation, the use of immunosuppressive drugs is necessary to prevent the rejection of the transplanted organ. However, these medications cause side effects such as gingival overgrowth, which requires regular check‐ups with a dentist 17,18 …”

Section: Introductionmentioning

confidence: 99%

Ulectomy in a patient with nephrotic syndrome under investigation for Galloway‐Mowat syndrome: a case report

Alves,

Javaroni,

Moura

et al. 2024

Special Care in Dentistry

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The aim of this study is to report a case in which a patient with nephrotic syndrome underwent surgery to remove fibrous gum tissue (ulectomy). An 8‐year‐old patient, diagnosed with early onset nephrotic syndrome due to a mutation in the NUP107 gene, had received a kidney transplant and was therefore taking various medications, including immunosuppressants. On oral examination, the patient was found to have a fibrous gingiva that was preventing the eruption of the upper permanent central incisors. A ulectomy was performed and the gingival tissue was sent for histopathological analysis, which showed normal aspects. The upper right central incisor was seen in the oral cavity 15 days after surgery. A second procedure was carried out to facilitate the eruption of the upper left incisor, which was visualized in the oral cavity 30 days later. In addition, oral manifestations such as maxillary atresia, ogival palate and mouth breathing were observed. Therefore, the role of the dental surgeon in the lives of transplanted children is considered important, as they often take various medications that can affect their oral health. Thus, early diagnosis and effective treatment will be essential to prevent future malocclusions and thus improve the quality of life of these patients.

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Drug-Induced Gingival Overgrowth

Cited by 6 publications

References 54 publications

Management of initial and surgical management of amlodipine-induced gingival enlargement with multifactorial etiology: a case report with 6 months follow-up

Management of initial and surgical management of amlodipine-induced gingival enlargement with multifactorial etiology: a case report with 6 months follow-up

Preventive Dentistry in Children with Special Needs: Narrative Review

Ulectomy in a patient with nephrotic syndrome under investigation for Galloway‐Mowat syndrome: a case report

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