Drug-Induced Glomerular Disease

Hogan, Jonathan J.; Markowitz, Glen S.; Radhakrishnan, Jai

doi:10.2215/cjn.01910215

Cited by 85 publications

(83 citation statements)

References 115 publications

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“…The MPO ANCA in patients with hydralazine-induced vasculitis is often in high titer (12), and patients often have antibodies directed to other antigens for perinuclear, elastase, and lactoferrin (8,13). The mechanism by which hydralazine induces MPO antibodies and vasculitis is not clear.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of hydralazine induced renal vasculitis

Timlin¹,

Liebowìtz²,

Jaggi³

et al. 2018

Eur J Rheumatol

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Section: Discussionmentioning

confidence: 99%

Outcomes of hydralazine induced renal vasculitis

Timlin¹,

Liebowìtz²,

Jaggi³

et al. 2018

Eur J Rheumatol

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“…Antineutrophil cytoplasmic antibodies (ANCA) are associated with cases of small vessel vasculitis in granulomatosis with polyangiitis (Wegener’s), microscopic polyangiitis, Churg-Strauss syndrome, “renal-limited” rapidly progressive glomerular nephritis (RPGN), and certain drug-induced vasculitis syndromes[2]. In these conditions, ANCA consistently have specificities for either PR3 or MPO, but almost never for both.…”

Section: Introductionmentioning

confidence: 99%

Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy

Gadde

Lee

Kidd

et al. 2016

WJN

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Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis.

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“…Production of autoantibodies is common during hydralazine treatment and patients may develop either a lupus-like or an AAV-like condition. Patients with hydralzine-induced vasculitis typically have very high levels of MPO-ANCA along with ANCA of different specificities such as elastase-ANCA and lactoferrin-ANCA [45]. In mild cases it is sufficient to stop the drug treatment, but in severe cases immunosuppressuion is needed.…”

Section: Hydralazinementioning

confidence: 99%

The clinical presentation and therapy of diseases related to anti-neutrophil cytoplasmic antibodies (ANCA)

Weiner

Segelmark

2016

Autoimmunity Reviews

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Anti-neutrophil cytoplasmic antibodies (ANCA) are a family of autoantibodies that react with proteins predominantly expressed in cytoplasmic granules of polymorphonuclear neutrophil granulocytes (PMNs). ANCA was initially detected using indirect immunofluorescence, allowing for different patterns such as p-ANCA (perinuclear) and c-ANCA (cytoplasmic) to be distinguished. Today it is common to detect the antibodies by immunochemical assays such as ELISA using purified proteins as antigens. The strongest association with ANCA is found in the pauci-immune small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). There is compelling evidence that ANCA contributes to the pathogenesis in these conditions. ANCA also occurs in 30%-40% of patients with eosinophilic granulomatosis with polyangiitis (EGPA) and anti-GBM disease, but is uncommon in other forms of vasculitis. ANCA with different specificities have been described with varying frequencies in diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, inflammatory bowel disease, endocarditis, chronic infections and hematopoietic malignancies. ANCA can also develop as an adverse event during pharmacological treatment. These entities are treated quite differently, with therapies ranging from immunosuppressive agents over antibiotics to simply removing the causative drug. A positive ANCA test thus requires a careful diagnostic work-up. (C) 2016 Elsevier B.V. All tights reserved

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Drug-Induced Glomerular Disease

Cited by 85 publications

References 115 publications

Outcomes of hydralazine induced renal vasculitis

Outcomes of hydralazine induced renal vasculitis

Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy

The clinical presentation and therapy of diseases related to anti-neutrophil cytoplasmic antibodies (ANCA)

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