Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

Shakya, Arvind

doi:10.5530/ijper.54.2.28

Cited by 18 publications

(14 citation statements)

References 80 publications

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“…I. aquatica (water spinach) is an emergent aquatic plant of Convolvulaceae family and estimated annual production was 0.08 million tonnes (2020) in India (Prasad et al, 2008;DARE, 2021). H. spinosa (gokulkanta) is herbaceous, medicinal plant in the Acanthaceae family with estimated annual production was 0.01 million tonnes (2020) in India (Shakya, 2020;DARE, 2021). These leaves are generally used as fodder for ruminants or treated as waste after harvesting.…”

Section: Introductionmentioning

confidence: 99%

Mixed leaf meal supplemented with exogenous enzyme and limiting amino acids can completely replace DORB (de-oiled rice bran) in the diet of Labeo rohita

Mondal

Sardar

Jayant

et al. 2022

Aquat. Living Resour.

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Various single leaf meal can substitute costly de-oiled rice bran (DORB) in farm made feed for carps. However, the use of mixed leaf meal (LM) in fish feed is not reported yet. Therefore, Vigna mungo, Ipomoea aquatica and Hygrophila spinosa leaf meals were blended in an equal proportion to prepare LM. DORB was the major energy source in control diet (C) and LM substituted 50% and 100% of DORB in LM20 and LM40 experimental diets, respectively. In addition, control diet (C), LM20 and LM40 diets were supplemented with limiting amino acids and exogenous carbohydrases and denoted as CE, LM20E and LM40E, respectively. Labeo rohita fingerlings were fed till satiation for 60 days. Fish fed with LM20E diet exhibited maximum growth rates and feed conversion (p <0.05) however these were similar in C and LM40 (p > 0.05). Amylase and aminotransferase activities were positively related with growth indices (p < 0.05). Difference in hematological indices was negligible (except total leukocyte count), and lactate dehydrogenase activities in DORB and LM-based fed groups (p > 0.05) while lower superoxide dismutase activities was observed in LM fed groups (p < 0.05). The present study concluded that LM up to 400 g kg–1 could be incorporated as complete DORB replacer in L. rohita diet, however, 200 g kg–1 LM supplemented with 0.98 g L-lysine kg–1 and 1 g exogenous enzyme kg–1 registered the best growth, nutrient utilization, feed conversion ratio, physio-metabolic responses and hematological status.

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Section: Introductionmentioning

confidence: 99%

Mixed leaf meal supplemented with exogenous enzyme and limiting amino acids can completely replace DORB (de-oiled rice bran) in the diet of Labeo rohita

Mondal

Sardar

Jayant

et al. 2022

Aquat. Living Resour.

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“…Hepato-injury caused by a variety of environmental pollutants, pathogenic micro-organism, viruses, drugs and chemical agents may account for various hepatic diseases such as jaundice, necrosis, hepatitis, fibrosis and cirrhosis etc. (Shakya, 2020). Liver diseases are one of the leading causes of illness and death globally.…”

Section: Introductionmentioning

confidence: 99%

تحسین الضررالکبدی المحدث بواسطة عقار الاسیتامینوفین باستخدام مسحوق ومستخلص الکرز الأسود فی الفئران

الله¹

2021

مجلة التربیة النوعیة و التکنولوجیا بحوث علمیة و تطبیقیة

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Liver injury is a major health problem .Continuous exposure to drugs, viral and bacterial infections and environmental toxins can trigger liver injury and eventually lead to various liver diseases. The present investigation aims to elucidate the possible hepatoprotective effect of black cherry on liver injury induced by administration of acetaminophen (APAP) (which known as paracetamol) to adult male albino rats. Animals were divided into 5 groups, each of 6 rats. The first group was kept as normal control group received (basal diet only). The other four groups fed on basal diet and daily oral dose of paracetamol (400 mg/kg body weight) by gastric tube for one week to induce hepato injury. The hepato-injury rats were classified into control (+ve) group and three treated rat groups which administered selymarin 100 mg/kg/day, 10% dried black cherry and 500mg/kg/day black cherry extract. The treatment period was designed for 28days. Total antioxidant and total plyphenols and flavonoids for black cherry extract were analyzed. Administration of APAP caused liver injury in rats evidenced by significant increase in serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatic malondialdehyde (MDA). In addition, significant decreases in hepatic catalase (CAT) and glutathione (GSH). Total (Phenolic, flavonoids and antioxidant) contents were (4.39 ± 0.33& 6.53 ± 0.46 and 85.94 ± 1.67) in black cherry respectively. Treatment with silymarin , dried black cherry and black cherry extract protect against liver injury as evidenced by significant decreases in liver MDA content, In addition, significant increases in hepatic CAT activity and GSH content. In conclusion: black cherry is rich source for polyphenols, flavonoids and total antioxidant sources so it may be have protective role against liver injury in rats.

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“…Research on Andrographis Paniculata coins andrographolide as the chief liver-protective and anti-liver-toxic constituent [14, 24 & 25] . Phyllanthus amarus is reported to show liverprotective effect by lowering down the content of thiobarbituric acid reactive substances (TBARS) [13,26,27] . Oral administration of ethanol (EtOH) extract from the leaves of Cnidoscolus chayamansa demonstrated a protective effect against the hepatotoxicity [28] .…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective plants role in human health: A cross-kingdom review

Motwani¹,

Gadhavi²,

Mangukia³

et al. 2021

J. Med. Plants Stud.

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Liver, being one of the most fundamental and vital organ existing in human body and performing significant role in regulation of enormous number of biological processes including metabolism of biomolecules, secretion, storage, detoxification and excretion of xenobiotics from body. Accomplishment of all these processes leads to acute or chronic hepatic injuries and liver dysfunctions, which sequentially contributes to global health care threat as well as it is a concern for pharmaceutical industry as despite all advancements in medicine there is still a lack of completely assured hepato-protective drugs which stimulate and enhance liver function. However, nature full fills these vacant spaces by providing a number of plant derived hepatoprotective phytochemicals, which are comparatively less toxic and this leads to introduction of an alternative phytotherapeutic approach i.e., the use of poly herbal formulations for treatment of liver diseases. Throughout the world, herbalists claim the use of a number of remedial plants for treatment of hepatic dysfunctions. Nevertheless, recent research also reveals that not only phytochemicals, but also regulatory microRNAs are being transferred from plant to animal kingdom. Thus, this leads to an alternative concept of cross-kingdom gene regulation by non-coding tiny molecules i.e. orally consumed plant derived xeno-MIRs play a chief role in human health regulation. The abilities of microRNAs to regulate cross-kingdom gene regulation have prompted the hopes to explore this novel concept in diagnosis, prognosis and treatment as potential therapeutic and dietary supplements. The present review is aimed to compile the available data of promising hepatoprotective plants and introduce the cross-kingdom gene regulation approach as potential therapy for human health care.

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Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

Cited by 18 publications

References 80 publications

Mixed leaf meal supplemented with exogenous enzyme and limiting amino acids can completely replace DORB (de-oiled rice bran) in the diet of Labeo rohita

Mixed leaf meal supplemented with exogenous enzyme and limiting amino acids can completely replace DORB (de-oiled rice bran) in the diet of Labeo rohita

تحسین الضررالکبدی المحدث بواسطة عقار الاسیتامینوفین باستخدام مسحوق ومستخلص الکرز الأسود فی الفئران

Hepatoprotective plants role in human health: A cross-kingdom review

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