Drug-induced lung disease.

Özkan, Metin; Dweik, Raed A.; Ahmad, Muzaffar

doi:10.3949/ccjm.68.9.782

Cited by 51 publications

(37 citation statements)

References 20 publications

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“…Many drugs, including hydroxyurea, imatinib and lenalidomide, are known to cause lung disease with a hypersensitivity reaction [15,16,17,18]. Consistent with this kind of reaction, all of our patients improved with discontinuation of the offending agent and administration of systemic corticosteroids.…”

Section: Discussionsupporting

confidence: 53%

Bronchoalveolar Lavage Cellular Patterns in Monoclonal Antibody-Induced Lung Disease

et al. 2014

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Background: The increase in the use of monoclonal antibodies (mAB) as a targeted therapy for a variety of diseases has been accompanied by an increase in reports of interstitial lung abnormalities in treated patients. Objective: Bronchoalveolar lavage (BAL) is routinely performed in these patients to rule out infection, so we sought to determine the BAL cellular pattern in individuals with mAB-induced lung disease (mAB-ILD). Methods: We utilized a case-control study design. Among patients treated with mAB, cases were defined as those with otherwise-unexplained interstitial lung abnormalities, which resolved after cessation of treatment, while controls were defined as those with interstitial abnormalities clearly explained by other etiologies. Results: From 2000 to 2012, we identified 9 cases and 7 controls. The mean age of the cases was 62.6 ± 26 years and 6 were female. The most common radiographic finding was diffuse ground-glass opacities. The most common BAL cellular pattern was mixed inflammation with moderate lymphocytic and mild neutrophilic alveolitis. The cases had a higher mean lymphocyte count than the controls (40.1 ± 32.6 vs. 13.1 ± 25.5, p = 0.008). The rest of the BAL cellular analyses were similar between the 2 groups. The median CD4:CD8 ratio in 7 patients with >15% lymphocytes was 0.9 (0.6-3). There was no significant difference in the CD4:CD8 ratio between the 2 groups. Conclusions: Mixed inflammation with moderate lymphocytic and mild neutrophilic alveolitis is the most common BAL cellular pattern in patients with mAB-ILD. Such findings may be useful for the early identification of mAB-ILD.

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Section: Discussionsupporting

confidence: 53%

Bronchoalveolar Lavage Cellular Patterns in Monoclonal Antibody-Induced Lung Disease

et al. 2014

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“…The clinical picture was that of interstitial pneumonitis [1,2]. Since there was no laboratory or historical evidence of any other interstitial lung disease, druginduced pneumonitis was considered most likely.…”

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confidence: 99%

Interstitial pneumonitis during lamotrigine therapy

Saravanan

Otaiku

Namushi

2005

Brit J Clinical Pharma

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“…This is caused by vascular injury or inflammation [6]. Previous reports suggest that many drugs can cause alveolar hemorrhage [5]. Some of these drugs cause capillaritis, while others cause diffuse alveolar damage or bland hemorrhage.…”

mentioning

confidence: 98%

“…DAH is one histopathologic pattern of drug-induced lung injury [3,5], which results from the disruption of the alveolar-capillary basement membrane. This is caused by vascular injury or inflammation [6].…”

mentioning

confidence: 99%