Drug induced malignancy: a focus on pioglitazone

Kelleni, Mina

doi:10.15406/ppij.2018.06.00190

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Moreover, our colleagues have stated that ibuprofen and the group of antidiabetic drugs known as thiazolidinediones [which are mostly obsolete, except in developing countries (Kelleni 2018 )] have similar effects on their proposed ACE2 expression, however, there were no references cited. To the best of the author’s pharmacological research, there’s a single published experiment that gathered those drugs and showed a protective effect of ibuprofen similar to pioglitazone, a member of the thiazolidinediones, against cardiac fibrosis in a rat model partially through their ability to increase ACE2 but in a protective manner (Qiao et al 2015 ).…”

Section: Are Nsaids Including Ibuprofen Hazardous In Covid-19?mentioning

confidence: 99%

ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror

Kelleni

2020

Inflammopharmacol

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During the COVID-19 pandemic, a correspondence, published at the Lancet Respiratory Medicine, that linked angiotensinconverting enzyme inhibitors, angiotensin receptor blockers and ibuprofen to a higher risk of SARS CoV-2 infection and complications, has influenced, when adopted by official health authorities, the practical management of COVID-19 with regard to non-steroidal anti-inflammatory drugs that were avoided in all COVID-19 management protocols all over the world. This manuscript discusses, from a pharmacological point of view, the points of weakness in the mentioned correspondence and it also lists some important contradictory review articles as well as clinical results that refuted its claims. The author chose to argue against each claim represented in the mentioned correspondence to confirm that ACEIs, ARBs and NSAIDs including ibuprofen should not be considered hazardous to be administered for COVID-19 patients and to warn against any future adoption of such unproved claims. Keywords COVID-19 • SARS CoV-2 • Aceis • Arbs • Ibuprofen Abbreviations ACEIs Angiotensin-converting enzyme inhibitors ARBs Angiotensin receptor blockers SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 COVID-19 Coronavirus disease 2019 D. Rainsford; Editor in Chief and Dr. Phil Berry; Deputy Editor of Inflammopharmacology for their highly valuable remarks as well as their timely and highly professional management of this manuscript. The author has tried since March 2020 to publish the main body of this manuscript and only on June 2020 a preprint has been published after a dozen of rejections without peer review (Kelleni M 2020, June 2,) and only Inflammopharmacology has accepted to peer review it. Funding None.

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Section: Are Nsaids Including Ibuprofen Hazardous In Covid-19?mentioning

confidence: 99%

ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror

Kelleni

2020

Inflammopharmacol

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“…Moreover, our colleagues have stated that ibuprofen and the group of antidiabetic drugs thiazolidinediones which are mostly obsolete, except in the developing countries 17 have similar effects on their proposed ACE2 expression citing no references at all. The author must stress, with utmost respect that the editor, and more importantly the peer reviewers of this correspondence, shouldn't have ever published such a serious suggestion without enough scientific support.…”

mentioning

confidence: 99%

ACEIs, ARBs, Ibuprofen linked to COVID-19: The other side of the broken mirror

Kelleni¹

2020

Preprint

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This article discusses from a pharmacological point of view, the points of weakness in a correspondence published at the Lancet Respiratory Medicine that has suggested a hypothesis relating ACEIs, ARBs and ibuprofen to be associated with a higher risk for COVID-19 infection and complications. This article also explains some unfortunate mistakes that have been made by some who have adopted this hypothesis and decided to unwisely recommend against these important drugs.

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Drug induced malignancy: a focus on pioglitazone

Cited by 2 publications

References 19 publications

ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror

ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror

ACEIs, ARBs, Ibuprofen linked to COVID-19: The other side of the broken mirror

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