Drug‐induced ocular side‐effects with isotretinoin

Abstract

Whereas there are numerous reported ocular side-effects from isotretinoin medication, we present the first case report of corneal steepening after systemic treatment with isotretinoin for seven and a half weeks. The case was associated with a significant drop in visual acuity which could not be explained from the refractive error change. All signs and symptoms were absent seven and a half weeks after the medication was withdrawn. The case indicates that eye care professionals need to be vigilant about the possibility of adverse ocular manifestations associated with the use of systemic medications.

Side effects of retinoid therapy on the quality of vision

“…Corneal steepening (23). -A 39-year-old female patient, taking isotretinoin (20 mg kg -1 daily) for seven and a half weeks, experienced blurred vision, transient loss of some parts of her visual field, dry eyes, peeling and erythema of the face and lips.…”

Changes in Anterior Chamber Parameters with the Pentacam Rotating Scheimpflug and Axial Length Measurements by Ultrasound in Patients Who Use Isotretinoin

“…14 Alteration of tear film secretion associated with the use of isotretinoin could reduce CCT values. 15 Santodomingo-Rubido et al 8 have reported corneal steepening in a case who used isotretinoin for the treatment of acne vulgaris. Fraunfelder et al have also reported keratoconus in four cases.…”

“…7 In addition, a case of corneal steepening associated with the use of this medication was recently reported. 8 The evaluation of anterior segment parameters may provide useful information that contributes towards our understanding of ocular pharmacokinetics, aqueous humour dynamics and ocular physiology.…”

Psoriasis Induced by Isotretinoin in Acne

“…The deterioration of visual acuity was associated with Corneal steepening. 8 In addition, Radmanesh described 2 cases anal fissures and rectal bleeding, and Stetson et al described one case of whitlow herpetiformis. 5 ' Isotretinoin (13-cis-retinoic acid) is a retinoid that has been used to treat a wide variety of conditions, some with great success.…”