Drug-induced oral lichenoid reactions: a real clinical entity? A systematic review

Fortuna, Giulio; Aria, Massimo; Schiavo, Julie

doi:10.1007/s00228-017-2325-0

Cited by 36 publications

(33 citation statements)

References 28 publications

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“…Drug‐induced OLRs are a rare adverse effect so it is important for health practitioners to be aware of this possibility, confirm the diagnosis by an adverse drug algorithm and report the case to their respective drug regulatory authority. In agreement with Fortuna et al and Myers et al, a universal protocol should be established to conclusively prove this association for each case. Table details drugs associated with lichenoid‐like reactions, and is adapted from Fortuna et al…”

Section: Drug‐induced Lichenoid Reactionssupporting

confidence: 66%

“…In agreement with Fortuna et al and Myers et al, a universal protocol should be established to conclusively prove this association for each case. Table details drugs associated with lichenoid‐like reactions, and is adapted from Fortuna et al…”

Section: Drug‐induced Lichenoid Reactionssupporting

confidence: 66%

“…Oral lichenoid reactions (OLRs) refer to a lesion that clinically and histologically resembles lichen planus . A wide range of drugs have been implicated in causing oral lichenoid reactions with conflicting presentations . The ambiguity of these case reports arise from the lack of biopsy confirming the diagnosis, the use of imprecise terminology when establishing a full diagnosis, when the histological appearance is similar to but not consistent with classical lichen planus, as well as the lack of the use of an adverse drug reaction validation protocol, such as the challenge‐dechallenge‐rechallenge (C‐D‐R) procedure or Naranjo algorithm …”

Section: Drug‐induced Lichenoid Reactionsmentioning

confidence: 99%

“…While there are numerous case reports of medications associated with oral lichenoid reactions, a systematic review showed that most evidence for this rare adverse effect exists for a few drugs only . Of the cardiac medications, most evidence exists for methyldopa, with one case of the reappearance of the oral lesions on rechallenge .…”

Section: Drug‐induced Lichenoid Reactionsmentioning

confidence: 99%

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A review and guide to drug‐associated oral adverse effects—Oral mucosal and lichenoid reactions. Part 2

Teoh

Moses

McCullough

2019

J Oral Pathology Medicine

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Dental practitioners and other health professionals commonly encounter and manage adverse medicine effects that manifest in the orofacial region. Numerous medicines are associated with a variety of oral adverse effects. However, due to lack of awareness and training, these side effects are not always associated with medicine use and are underreported to pharmacovigilance agencies by dentists and other health professionals. This article aims to inform health professionals about the various oral adverse effects that can occur and the most commonly implicated drugs to improve the management, recognition and reporting of adverse drug effects. This article follows on from Part 1; however, the focus here is on lichenoid reactions and oral mucosal disorders including oral aphthous‐like ulceration, mucositis and bullous disorders such as drug‐induced pemphigus, pemphigoid, Stevens‐Johnson syndrome and toxic epidermal necrolysis.

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Section: Drug‐induced Lichenoid Reactionssupporting

confidence: 66%

Section: Drug‐induced Lichenoid Reactionssupporting

confidence: 66%

Section: Drug‐induced Lichenoid Reactionsmentioning

confidence: 99%

Section: Drug‐induced Lichenoid Reactionsmentioning

confidence: 99%

See 2 more Smart Citations

A review and guide to drug‐associated oral adverse effects—Oral mucosal and lichenoid reactions. Part 2

Teoh

Moses

McCullough

2019

J Oral Pathology Medicine

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“…(6). Their definition leaves open the opportunity of using the terms "adverse reaction" and "adverse effects" interchangeably, in keeping with the understanding that adverse effect points to the drug standpoint, while adverse reaction points to the patient standpoint (7).…”

Section: Introductionmentioning

confidence: 99%

An Update on Drug-induced Oral Reactions

Yousefi¹,

Abdollahi²

2018

J Pharm Pharm Sci

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-Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. Electronic searches were performed in Scopus, Google Scholar, Cochrane and PubMed databases, for articles published between January 2008 and August 2017. Two authors screened the titles and abstracts for eligibility. Finally, 56 studies included in this review. There was no systematic homogeneity in the included studies; thereby no meta-analysis was performed. The most frequent oral ADR was xerostomia, and the most reported cause was antihypertensive medications. Cardiovascular drugs were the most reported culprit agents for induction of oral ulcerative and vesiculo-bullous lesions, followed by methotrexate. Nonsteroidal anti-inflammatory drugs (NSAIDs) and β-blockers were found the most common responsible drugs for induction of oral lichen planus.

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The association between high‐risk human papillomavirus and oral lichen planus

Mohammadi

Abbaszadeh

Mohtasham

et al. 2023

Clinical & Exp Dental Res

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Objectives: Oral lichen planus (OLP) is a cell-mediated inflammatory mucosal disorder and is classified as an oral potentially malignant disorder. Some research has shown that apoptosis in OLP cells is similar to a viral infection such as human papillomavirus (HPV). So, the aim of this case-control study was to investigate the association of high-risk HPV with OLP.Material and Methods: DNA was extracted from 25 formalin-fixed, paraffin-embedded (FFPE) OLP tissues and 25 FFPE normal oral tissues as case and control groups, respectively. The presence of high-risk HPV16 and HPV18 DNA was investigated by polymerase chain reaction (PCR). p-value<.05 was considered significant.Results: Twelve samples (48%) of OLPs were positive for HPV16, compared with six samples (24%) of controls; although the difference was not significant, it was borderline (p = .07). Three samples (12%) of OLPs were positive for HPV18 compared with one sample (4%) of controls; the difference was not significant (p = .3). The total frequency of both high-risk HPV were 14 samples (56%) of OLPs and 7 samples (28%) of controls; there was a significant association between the high-risk HPV and OLP (p = .04). High-risk HPVs was more prevalent in erosive-atrophic (EA) form of OLP as compared to non-EA form, although the difference was not significant (p = .13). Conclusions:The results suggest a significant association between high-risk HPVs and OLP.

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Drug-induced oral lichenoid reactions: a real clinical entity? A systematic review

Cited by 36 publications

References 28 publications

A review and guide to drug‐associated oral adverse effects—Oral mucosal and lichenoid reactions. Part 2

A review and guide to drug‐associated oral adverse effects—Oral mucosal and lichenoid reactions. Part 2

An Update on Drug-induced Oral Reactions

The association between high‐risk human papillomavirus and oral lichen planus

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