2007
DOI: 10.1080/01926230601156237
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Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Abstract: Awareness of the dangers of drug-induced thrombosis has recently been heightened and led to demand for improved testing methodology. For example, reports indicating that some selective inhibitors of cyclooxygenase-2 (COX-2) increase the risk of myocardial infarction and atherothrombotic events caused the withdrawal of rofecoxib from global markets and the issuance of warnings concerning the usage of other COX-2 inhibitors. Drugs may exert a prothrombotic state by a variety of mechanisms-those affecting the ves… Show more

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Cited by 40 publications
(28 citation statements)
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“…Selective inhibitors of COX-2 Rofecoxib and Valdecoxib were withdrawn from market in 2007 because of increased risk of myocardial infarction and athero-thrombotic involvements. 4 Similarly, the restrictions to the use of Rosiglitazone are based on data of ADR reports which shows an elevated risk of heart attacks in patients treated with it. The decision to restrict access to Rosiglitazone was made on September 23, 2010 US-FDA.…”
Section: Introductionmentioning
confidence: 99%
“…Selective inhibitors of COX-2 Rofecoxib and Valdecoxib were withdrawn from market in 2007 because of increased risk of myocardial infarction and athero-thrombotic involvements. 4 Similarly, the restrictions to the use of Rosiglitazone are based on data of ADR reports which shows an elevated risk of heart attacks in patients treated with it. The decision to restrict access to Rosiglitazone was made on September 23, 2010 US-FDA.…”
Section: Introductionmentioning
confidence: 99%
“…Since a layer of titanium oxide is formed on its surface, preventing the diffusion of nickel atoms, nitinol is considered a biologically inert material (Shabalovskaya 2002). Nevertheless, it should be taken into consideration that thrombotic complications can occur when implanted in small arteries (Ramot and Nyska 2007;Ramot, Nyska, and Spectre 2013).…”
Section: Discussionmentioning
confidence: 99%
“…It also negatively interferes with the production of nitric oxide [18]. In addition, it leads to DNA damage, blocking of ATP and release of proapoptotic proteins.…”
Section: Mechanisms Of Drug Cardiotoxicity and Other Chemical Substancesmentioning
confidence: 99%