Drug interaction between methamphetamine and antihistamines: behavioral changes and tissue concentrations of methamphetamine in rats

Okuda, Tomohiro; Ito, Yukiko; Nakagawa, Naoto; Hishinuma, Takanori; Tsukamoto, Hiroki; Iwabuchi, Kentaro; Watanabe, Takehiko; Kitaichi, Kiyoyuki; Goto, Junichi; Yanai, Kazuhiko

doi:10.1016/j.ejphar.2004.10.022

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…Different mechanisms may also account for the different time course of stereotypies induced by apomorphine and methamphetamine. The nonsignificant effect of ciproxifan against methamphetamine did not result from pharmacokinetic interactions between the two drugs (Okuda et al 2004) since ciproxifan used at the same dose could suppress other methamphetamine-induced responses (Pillot et al 2003). Its effect on stereotypies appears also much lower than its effect on methamphetamine-induced hyperlocomotion in mice (Morisset et al 2002).…”

Section: Discussionmentioning

confidence: 87%

Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists

et al. 2010

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Their total absence of effect in several validated animal models of the disease does not support antipsychotic properties of H(3)-receptor inverse agonists. However, their positive effects previously reported in behavioral tasks addressing learning, attention, and memory maintain the interest of H(3)-receptor inverse agonists for the treatment of cognitive symptoms of schizophrenia as adjunctive medications.

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Section: Discussionmentioning

confidence: 87%

Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists

et al. 2010

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“…Furthermore, according to the fact that first generation histamine H 1 -receptor antagonists potentiate methamphetamine (METH)-induced psychomotor activation (7), some studies have reported that histaminergic neurons have inhibitory effects on dopaminergic neurons (6,8). However, we have demonstrated that first generation antihistamines alter the pharmacokinetics of METH in rats and that drug-drug interaction is involved in the potentiating effects of antihistamines on METH-induced psychomotor activation (9). From these findings, it is suggested that drug-drug interaction may exist between antihistamines and some psychostimulants.…”

Section: Introductionmentioning

confidence: 74%

“…Therefore, there might be a drug-drug interaction between thioperamide and psychostimulants, including METH and cocaine. As reported previously (9), it is important to pay special attention to drug-drug interaction in studies involving the use of two different drugs.…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

et al. 2009

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Abstract. Histamine H 3 receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes. To examine whether deficiency in histamine H 3 receptors influences psychostimulant-induced behavioral sensitization and reward, we examined locomotor activity, conditioned place preference (CPP), and c-Fos expression in histamine H 3 receptor-gene knockout mice (H3KO) and their wild-type (WT) counterparts before and after treatment with methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA). The increase in locomotion induced by treatment with METH or MDMA was lower in histamine H3KO mice than in WT mice, while the locomotor sensitization was developed by METH or MDMA in both strains. However, no significant difference in METH-and MDMA-induced preference scores of CPP between histamine H3KO mice and WT mice was observed. Following treatment with METH, the number of c-Fos-positive neurons in the the caudate-putamen of histamine H3KO mice was lower than that in the caudate-putamen of WT mice. In contrast, there was no significant difference in the number of the psychostimulant-induced c-Fos-positive cells in the nucleus accumbens between the two strains of mice. These findings suggest that deficiency in histamine H 3 receptors may have inhibitory effects on psychostimulant-induced increase in locomotion, but insignificant effects on the reward.

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“…For example, methamphetamine-induced hyperactivity was increased in histamine-deficient mice (Kubota et al 2002). Moreover, the inhibition of the histaminergic system with H 1 antagonists (pyrilamine, chlorpheniramine) potentiated methamphetamine-and amphetamine-induced hyperactivity and stereotypies (Naylor and Costall 1971;Ito et al 1997;Okuda et al 2004). Conversely, the administration of agents that increase the brain histamine content was shown to diminish amphetamine-and methamphetamine-induced hyperactivity.…”

Section: Discussionmentioning

confidence: 90%

The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward

et al. 2006

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Drug interaction between methamphetamine and antihistamines: behavioral changes and tissue concentrations of methamphetamine in rats

Cited by 9 publications

References 28 publications

Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists

Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists

Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward

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