Drug interactions in primary health care in the George subdistrict, South Africa: a cross-sectional study

Kapp, Paul; Klop, A C; Jenkins, Louis

doi:10.1080/20786204.2013.10874307

Cited by 25 publications

(41 citation statements)

References 19 publications

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“…(6,11) Such aspect is particularly important, once those patients have higher risks of suffering from adverse effects and drug interactions. (2,11) The association between psychiatric drugs and Common Mental Disorders, revealed in this study, is confirmed by previous studies. (5) Despite such association, one cannot help but notice, in this study, the fact that among the people who were negative for Common Mental Disorders, 15.1% made use of psychiatric drugs.…”

Section: Discussionsupporting

confidence: 78%

“…Consistent with the results found in this study, other studies show that such medication classes are the ones which are the most prescribed in different countries. (1,2) The high rate of fluoxetine prescriptions may be justified by some factors. Firstly, fluoxetine is classified as a selective inhibitor for serotonin reception, a class of antidepressants which are safer and more tolerated.…”

Section: Discussionmentioning

confidence: 99%

“…(7) The usage rate of psychiatric drugs observed (25.8%) was higher than the one found in the literature, which ranges from 9 to 13%. (1,2) In regards to the types of psychiatric drugs prescribed, the most prevalent ones were the ones in the class of antidepressants, followed by benzodiazepine drugs. Consistent with the results found in this study, other studies show that such medication classes are the ones which are the most prescribed in different countries.…”

Section: Discussionmentioning

confidence: 99%

“…(1) Such phenomenon seems to happen worldwide, as studies conducted in other countries showed high usage rates for them. (2) Although the benefit related to the use of psychiatric drugs as a therapeutic modalities cannot be denied, their popularization gave rise to questions regarding the real need for them. (3) Not always are psychiatric drugs used to treat specific mental disorders; sometimes the very doctor prescribing them cannot specify the reason some of their patients use them.…”

Section: Introductionmentioning

confidence: 99%

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Prevalência do uso de psicotrópicos e fatores associados na atenção primária à saúde

et al. 2015

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Objective: Investigating the prevalence in the use of psychotropics and associated factors in primary health care withsocio-demographic and pharmacotherapeutic factors, medical history, and Common Mental Disorders. Methods: A cross-section study which includes 430 primary health care patients. The research instruments were Self-reporting Questionnaires and medical records. A chi-squared test was used in the univariate analysis, and a logistic regression was used in the multivariate analysis. Results: The prevalence in the use of psychotropics was 25.8%. There was an association among the use of psychiatric drugs and common mental disorders, use of non-psychiatric drugs, number of medications prescribed,number of pills a day, clinical pathologies, age, and schooling. In the multivariate analysis, the predictors for the use of psychiatric drugs were: common mental disorders, clinical pathologies, and schooling. Conclusion: The prevalence in the use of psychiatric drugs and the associated factors varied according to the univariate or the multivariate analyses. ResumoObjetivo: Investigar a prevalência de uso de psicotrópicos e fatores associados na atenção primária à saúde com fatores sociodemográficos, farmacoterapêuticos, histórico de saúde e Transtornos Mentais Comuns. Método: Estudo transversal que incluiu 430 pacientes de atenção primária à saúde. O instrumento de pesquisa foi o Self-reporting Questionnaire e prontuários. Para análise, utilizou-se teste Qui-quadrado na análise univariada e regressão logística na multivariada. Resultados: A prevalência de uso de psicotrópicos foi de 25,8%. Houve associação entre uso de psicofármacos e transtornos mentais comuns, uso de medicamentos não psicofármacos, número de medicamentos prescritos, número de comprimidos/dia, patologias clínicas, idade e escolaridade. Na análise multivariada os preditores para uso de psicofármacos foram: transtornos mentais comuns, patologias clínicas e escolaridade. Conclusão: A prevalência de uso de psicofármacos e os fatores associados variaram conforme a análise uni ou multivariada.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalência do uso de psicotrópicos e fatores associados na atenção primária à saúde

et al. 2015

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“…Also, there was a direct correlation between the number of medicines prescribed and the occurrence of adverse events in South Africa. [45] Avoidance of polypharmacy in the management of depression is necessary to reduce the disease burden and health cost to the patients.…”

Section: Discussionmentioning

confidence: 99%

Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

Kehinde

Anyika

Abah

2017

JHA

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Backgroud: The paucity of information on prescribing patterns and use of antidepressants in accordance with practice guidelines necessitated this study in Nigeria. Objective: To assess the prescribing patterns of antidepressants, average cost of prescriptions and the index of rational drug prescribing (IRDP) in a Nigerian tertiary care hospital. Methods: A retrospective study which involved the assessment of 683 prescriptions and case records of patients who received antidepressants from 1 st January 2013 to 31 st December 2014 was conducted. Information on diagnosis, patients' demographics, prescribing patterns and cost of medications was obtained therefrom. Compliance to the World Health Organization (WHO) prescribing indicators and Nigerian Standard Treatment Guidelines (STG) was assessed. The IRDP for antdepressants was determined using a validated mathematical model. The statistical analysis was performed using SPSS version 20. Results: Tricyclic antidepressants (TCAs) were the most commonly prescribed drug group (61.3%), followed by selective serotonin re-uptake inhibitors (SSRIs) with a total of 38.7%. On the average, three drugs were prescribed per prescription, while 60.3% and 38.3% of the drugs were prescribed from National Essential Medicine List (NEML) and STG respectively. The IRDP was 3.96 over 5 points. The average cost of drugs per prescription was 4.2 USD. The cost of drugs in the prescriptions written according to STG was lower compared to that in prescriptions not compliant with the STG (p < .001).Conclusions: TCAs are the most commonly prescribed antidepressants due to their affordability. The generic prescribing, medicines prescribed from the NEML and in compliance with the STG were less than the WHO standard. The rational drug use is suboptimal. Better prescribing habits, affordability and use of newer antidepressants should be encouraged by the hospital management.

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Ogunbanjo¹

2013

South African Family Practice

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Drug interactions in primary health care in the George subdistrict, South Africa: a cross-sectional study

Cited by 25 publications

References 19 publications

Prevalência do uso de psicotrópicos e fatores associados na atenção primária à saúde

Prevalência do uso de psicotrópicos e fatores associados na atenção primária à saúde

Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

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