Drug Interactions With Diazepam

Bojanić, Zoran; Bojanić, Novica; Bojanić, Vladmila; Lazović, Marko

doi:10.5633/amm.2011.0214

Cited by 6 publications

(10 citation statements)

References 24 publications

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“…Furthermore, the hydrophobicity of diazepam (log DOW: 3.08) could also favour its rejection because its molecules would be partially adsorbed by both the membrane and EfOM macromolecules, especially in proteins (Bojanić et al, 2011;López-Fernández et al, 2014). Similar behaviour was observed for diclofenac, which presented the highest molecular weight of all target compounds and was highly hydrophobic (log DOW: 4.64) at the studied pH range.…”

Section: Rejection Of Ionic Target Compounds In Wwtp Secondary Effluentsupporting

confidence: 55%

Nanofiltration as tertiary treatment method for removing trace pharmaceutically active compounds in wastewater from wastewater treatment plants

et al. 2017

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The ever-increasing occurrence and persistence of pharmaceutically active compounds (PhACs) in soils, sediments, drinking water supplies and wastewater effluents are a matter of serious environmental concern for governments and researchers worldwide. Nanofiltration as tertiary treatment method can be a viable and practical tool to remove these pollutants from aquatic environments. However, organic matter present in water sources can foul the membrane surface during operation, thus being potentially able to affect the membrane performance. Therefore, fouling mechanisms could heavily influence on the removal efficiencies. The purpose of this study was to investigate the implementation of three nanofiltration membranes (TFC-SR2, NF-270 and MPS-34) and to study both the rejection of trace PhACs and the fouling mechanisms for each membrane as a function of feed solution pH. Fouling mechanisms were predicted by Hermia's model adapted to cross-flow configurations. Results demonstrated that higher removals were obtained at slightly alkaline pH, especially for anionic trace PhACs. At the same conditions, more severe fouling was observed, which resulted in strong flux declines and an increase in hydrophobicity. This indicates that the attached organic matter on the membrane surface acts as a secondary selective barrier for separation.

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Section: Rejection Of Ionic Target Compounds In Wwtp Secondary Effluentsupporting

confidence: 55%

Nanofiltration as tertiary treatment method for removing trace pharmaceutically active compounds in wastewater from wastewater treatment plants

et al. 2017

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“…DZP interacts with alcohol and many different classes of drugs, including analgesics, antibiotics, anticonvulsants and antidepressants. In addition, oral contraceptives can inhibit the biotransformation of DZP, thereby increasing its effects and possibly increasing the incidence of break-through bleeding [87]. However, DZP should be avoided in pregnant women as there is evidence for an increased risk of harmful effects on the human fetus or neonate without causing malformations [88].…”

Section: Pharmacodynamics Pharmacokinetics and Metabolismmentioning

confidence: 99%

Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability

et al. 2022

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Status epilepticus (SE) is an acute, life-threatening medical condition that requires immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings. Benzodiazepines (BZDs) are the first-line treatment for SE worldwide due to their efficacy, tolerability, and rapid onset of action. Although all BZDs act as allosteric modulators at the inhibitory gamma-aminobutyric acid (GABA) A receptor, the individual agents have different efficacy profiles and pharmacokinetic and pharmacodynamic properties, some of which differ significantly. The conventional BZDs clonazepam, diazepam, lorazepam and midazolam differ mainly in their durations of action and available routes of administration. In addition to the common intravenous, intramuscular and rectal administrations that have long been established in the acute treatment of SE, other administration routes for BZDs-such as intranasal administration-have been developed in recent years, with some preparations already commercially available. Most recently, the intrapulmonary administration of BZDs via an inhaler has been investigated. This narrative review provides an overview of the current knowledge on the efficacy and tolerability of different BZDs, with a focus on different routes of administration and therapeutic specificities for different patient groups, and offers an outlook on potential future drug developments for the treatment of prolonged seizures and SE.

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“…Drug interactions between diazepam and phenytoin occur at the pharmacokinetic level, with hydantoin being metabolized by hepatic isoenzymes CYP2C9 and CYP2C19. ( 29 , 30 ) Benzodiazepines are metabolized by a distinct isoform (CYP3A4), however, diazepam is specifically metabolized extensively by CYP2C19. ( 31 ) Diazepam may, therefore, compete with the metabolizing enzyme and significantly increase phenytoin concentrations, inducing toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…( 31 ) Diazepam may, therefore, compete with the metabolizing enzyme and significantly increase phenytoin concentrations, inducing toxicity. ( 29 , 30 ) Carbamazepine, may compromise the therapeutic action of diazepam through metabolic activity of the CYP3A4 isoenzymes. ( 31 – 34 )…”

Section: Discussionmentioning

confidence: 99%

Drug interactions in maternal intensive care: prevalence, risk factors, and potential risk medications

Pessoa¹,

Clemente²,

Costa³

et al. 2019

Einstein (São Paulo)

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Objective: To characterize severe potential drug interactions in maternal intensive care, and to determine their frequency, risk factors and potential risk medications. Methods: An observational and longitudinal study conducted between December 2014 and December 2015 in a maternal intensive care unit. Clinical data were collected and severe potential drug interactions were identified on pregnant inpatients. The drug interactions were classified by type, prevalence and exposure rate. A multivariate logistic regression model was used to identify the severe potential drug interactions and the related drugs (p<0.05). Results: A total of 95.1% of patients were exposed to, at least, one potential drug interaction; in that, 91.7% 33.9% were related to, respectively, moderate and severe potential drug interactions. The patients were exposed, on average, on 69.2% of days they were in the intensive care unit. The main drugs involved in more severe drug interactions were magnesium sulfate, metoclopramide, propranolol and diazepam. Conclusion: The severe potential drug interactions were observed in almost all patients of the study, and, approximately one third of those interactions were related to greater severity and resulted in exposure during long hospital stay. The higher number of prescribed drugs and its previous use of medications at home increase the occurrence of severe potential drug interactions.

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Drug Interactions With Diazepam

Cited by 6 publications

References 24 publications

Nanofiltration as tertiary treatment method for removing trace pharmaceutically active compounds in wastewater from wastewater treatment plants

Nanofiltration as tertiary treatment method for removing trace pharmaceutically active compounds in wastewater from wastewater treatment plants

Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability

Drug interactions in maternal intensive care: prevalence, risk factors, and potential risk medications

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