Drug interactions with radiopharmaceuticals

Abstract

Considerable information on documented drug and radiopharmaceutical interactions has been assembled in a tabular form, classified by the type of nuclear medicine study. The aim is to provide a rapid reference for nuclear medicine staff to look for such interactions. The initiation of drug chart monitoring or drug history taking of nuclear medicine patients and the reporting of such events are encouraged.Reduced tumour uptake Reduced tumour uptake Reduced tumour uptake Reduced tumour uptake Increased tumour retentionBone imaging using 99"Tc-diphosphonafes Aluminium-containing drugs [50,51] Cortisone [52] Reduced uptake in bone, increased hepatic and renal uptake Reduced uptake in bone trauma

Uncaria tomentosa extract: evaluation of effects on the in vitro and in vivo labeling of blood constituents with technetium-99m

“…The in vitro effect of the Uncaria tomentosa extract on radiolabeling of blood constituents may be due to four possible mechanisms: (i) chelation of stannous and/or pertechnetate ions; (ii) competition of Tc-99m/stannous ions by the bindings sites; (iii) interference in the redox state of the labeling system, and (iv) blockage of calcium channels (Hesslewood et al, 1994;Bernardo-Filho et al, 2005). Results obtained from blood of animals treated with the extract, have shown that metabolization of Uncaria tomentosa extract after in vivo treatment was unable to alter the labeling of the blood constituents.…”

Effects of clove (Caryophyllus aromaticus L.) on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells

“…(Hesslewood and Leung, 1994;Owunwanne et al, 1995;Sampson, 1999). Blood constituents labeled with 99mTc have been used in several clinical examinations (Saha, 2004) and also as an experimental assay on an attempt to verify the effect of drugs ).…”

Acetylsalicylic acid and labeling of blood constituents with technetium-99m

“…Therapeutic drugs can modify the nature or amount of the 99mTc-radiopharmaceutical bound to blood constituents and result in an unexpected behavior of the radiopharmaceutical (Hladik III et al, 1987;Hesslewood and Leung, 1994;Sobal and Sinzinger, 2001;Welling et al, 2002;Fonseca et al, 2005). Thus, the evaluation of the influence of drugs on the fixation of 99mTc in blood constituents is important.…”