Drug Jelly Dosage as an Alternative to Gavage for Long-Term Oral Drug Administration in Rhesus Monkeys

Zhang, S.; Ye, B.; Zeng, Li; Chen, Y.; He, Sirong; Wang, C.; Li, X.; Zhao, Jinge; Shi, Min; Wang, L.; Li, H.; Cheng, Jingqiu; Wang, W.; Lu, Yunfeng

doi:10.1097/00007890-201211271-00255

Cited by 7 publications

(8 citation statements)

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“…One study suggests oral gavage should be abandoned for hazard assessments of endocrine disrupting chemicals, because it is stressful with manual restraint in conscious NHPs 35 , 36 and interferes with endocrine responses 37 . Oral gavage, especially long-term 38 , can carry well-known risks, including respiratory interference, damage to the stomach or esophagus, and granulomatous inflammation 36 , 39 , and potentially confound experimental outcomes 40 . Less than 1 percent of administered bisphenol A was bioavailable in blood in a gavage experiment with monkeys, while bisphenol A fed in a piece of fruit resulted in over 7 percent of administered bisphenol A being bioavailable in blood 37 .…”

Section: Discussionmentioning

confidence: 99%

“…Less than 1 percent of administered bisphenol A was bioavailable in blood in a gavage experiment with monkeys, while bisphenol A fed in a piece of fruit resulted in over 7 percent of administered bisphenol A being bioavailable in blood 37 . Alternative ways can reduce gavage-induced stress, such as feeding a compound mixed with a solution, food and pill 37 , 38 , 41 or giving a compound via implanted devices, such as osmotic pump. In this study banana-glucose feed created a nature way for oGTT in NHPs accepted glucose voluntarily.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates (Macaca Fascicularis)

Wang

Qiao

et al. 2017

Sci Rep

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Timely knowing glucose level helps diabetic patients to manage the disease, including decisions about food, physical activity and medication. This study compared two continuous glucose monitoring systems in conscious and moving-free nonhuman primates (NHPs, Macaca fascicularis). Each normoglycemic or diabetic monkey was implanted with one Dexcom G4 Platinum subcutaneously or one HD-XG glucose sensor arterially for glucose monitoring. The glucose levels measured by both telemetry devices significantly correlated with the glucometer readings. The data of oral glucose tolerance test (oGTT) showed that the glucose levels measured by either Dexcom G4 Platinum or HD-XG transmitter were very similar to glucometer readings. However, compared to HD-XG transmitter or glucometer, Dexcom G4 Platinum detected a decreased glucose peak of ivGTT with approximately 10 min delay due to interstitial glucose far behind blood glucose change. Our data showed the advantages of the telemetry systems are: (1) consecutive data collection (day and night); (2) no bleeding; (3) no anesthesia (moving freely); (4) recording natural response without physical restriction and stress; (5) less labor intensity during ivGTT and other tests; (6) quick outcomes without lab tests. This article summarized and compared the differences of the general characteristics of two continuous glucose monitoring systems in diabetic research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates (Macaca Fascicularis)

Wang

Qiao

et al. 2017

Sci Rep

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“…Graft function was monitored by detection of C‐P and HbA1C in recipient peripheral blood, and liver biopsies were performed to visualize the NPI graft by immunohistochemistry. All of the NPI recipients received immunosuppressive therapy consisting of inductive immunosuppression including 250 mg methylprednisolone on d −1 and 25 mg on d 0; 3 mg/kg/d daclizumab (Zenapax) on d 0–2; and gelatin containing 0.3 and 0.6 mg/kg/d tacrolimus and sirolimus, respectively, administered orally until the experiment ended (27).…”

Section: Methodsmentioning

confidence: 99%

MSCs promote the development and improve the function of neonatal porcine islet grafts

Wang

et al. 2018

FASEB j.

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Deficient insulin secretion caused by immaturity is the predominant disadvantage of neonatal porcine islets (NPIs) when they serve as a source for islet xenotransplantation. We hypothesize that the transplantation of NPIs with a combination of mesenchymal stem cells (MSCs) can accelerate NPI maturation and improve the engraftment and function of NPIs. After indirect coculturing with monkey MSCs over 21 d, insulin secretion and the expression of regulatory genes relevant to development were assessed in NPIs. NPIs alone or in combination with allogeneic MSCs were intraportally transplanted into diabetic monkeys. Glycemic control was monitored, and graft function was evaluated. Our results suggest that MSCs benefit both the development and proliferation of NPIs in the coexisting systems in vitro and in vivo. These effects are dependent on platelet-derived growth factor receptor-α and are relevant to the inhibition of downstream target Notch1 signaling and the activation of PI3K/protein kinase B signaling.-He, S., Wang, C., Du, X., Chen, Y., Zhao, J., Tian, B., Lu, H., Zhang, Y., Liu, J., Yang, G., Li, L., Li, H., Cheng, J., Lu, Y. MSCs promote the development and improve the function of neonatal porcine islet grafts.

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“…Moreover, drug dosage must be exact enough to maintain therapeutic drug level; however, long-term oral drug administration is challenging in transplant recipient NHPs. 3 Sirolimus is an oral immunosuppressive drug that has been used as immunosuppressive maintenance drug in many transplantation studies, including pig to NHPs islet xenotransplantation. 4 Fortunately, the monkeys tend to eat sirolimus (Rapamune tablet 1 mg) spontaneously, because it is formulated as sugarcoated tablet.…”

Section: Introductionmentioning

confidence: 99%

“…Oral immunosuppressive drugs have to be often administered more than one kind and even administered for long‐term period in most transplantation studies. Moreover, drug dosage must be exact enough to maintain therapeutic drug level; however, long‐term oral drug administration is challenging in transplant recipient NHPs …”

Section: Introductionmentioning

confidence: 99%

Gastrostomy tube placement for long‐term oral drug administration in non‐human primates

Kim

Shin

Min

et al. 2017

Xenotransplantation

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The complication of gastrostomy included a transient inflammation in the skin and peritonitis caused by a leakage around implantation site (one case), which could be overcome by changing suture method and tube type to interlocking box suture and Tri-Funnel Replacement Gastrostomy tube, respectively. Despite these complications, oral drug administration using gastrostomy tube allowed us to perform accurate dosage of drug administration and to reduce the stress that both the monkey and the researcher may experience. Taken together, this study showed that gastrostomy tube placement is a better alternative to oral drug administration in restraint for long-term oral drug administration in rhesus monkeys who tend to refuse to eat the mixture of drug and fruit juice.

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Drug Jelly Dosage as an Alternative to Gavage for Long-Term Oral Drug Administration in Rhesus Monkeys

Cited by 7 publications

References 0 publications

Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates (Macaca Fascicularis)

Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates (Macaca Fascicularis)

MSCs promote the development and improve the function of neonatal porcine islet grafts

Gastrostomy tube placement for long‐term oral drug administration in non‐human primates

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