Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities

Abstract

Current artificial periostea mainly focus on osteogenic activity but overlook structural and mechanical anisotropy, as well as the importance of antibacterial and anti-inflammatory properties. Here, inspired by the anisotropic structure of wood, the delignified wood (named white wood, WW) with a porous and highly oriented cellulose fiber skeleton was obtained, which was further filled with polyvinyl alcohol (PVA) hydrogel loaded with curcumin (Cur) and phytic acid (PA). The prepared wood-derived hydrogel composite membranes can not only exhibit an obvious anisotropic structure and good mechanical properties but also sustainably release loaded drugs to obtain long-term biological activities. Creatively, PA can effectively improve the bioavailability of Cur; more importantly, Cur and PA play an obvious synergistic effect in antibacterial, anti-inflammatory, and osteogenic activities. Compared with the woodderived hydrogel composite membranes without drug loading, as well as loaded with Cur or PA only, these loaded with Cur and PA are significantly more conducive to inhibiting the growth of bacteria and inflammatory response and facilitating the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. This kind of anisotropic woodderived hydrogel composite membrane with fantastic antibacterial, anti-inflammatory, and osteogenic activities is expected to be ideal artificial periostea.

Highly Elastic and Anisotropic Wood‐Derived Composite Scaffold with Antibacterial and Angiogenic Activities for Bone Repair

“…[ 2a,13 ] Due to the unique microstructure and mechanical properties of wood, fully delignified wood (WW) with a porous and highly oriented cellulose fiber skeleton has jumped into our view. [ 14 ] However, the structure of WW is loose and unstable in a wet state, so it cannot be used as bone repair material alone. Therefore, we designed to introduce drug‐loaded polyvinyl alcohol (PVA) hydrogel into the WW, thus endowing the WW with stability, flexibility, and biological activities.…”

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

“…120 Luo et al filled Cur into polyvinyl alcohol (PVA) hydrogels containing phytic acid (PA) to prepare wood-derived hydrogel composite membranes, which can not only exhibit an obvious heterogeneous structure and good mechanical properties, but also release the loaded drugs sustainably to obtain long-term biological activity. 121 Furthermore, they found that the Cur-PA-loaded composite membranes significantly inhibit bacterial growth and inflammation, and promote adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells.…”

Dual Factor-Loaded Artificial Periosteum Accelerates Bone Regeneration

“…Currently, artificial periosteums are mainly prepared by hydrogel and electrostatic spinning membranes. Although both methods can construct extracellular matrix (ECM)-like structures to promote the adhesion, proliferation, and differentiation of stem cells, − it is difficult to realize the slow-release function due to the good hydrophilicity of hydrogels, , which limits their application in artificial bone membranes. Therefore, the preparation of artificial bone membranes using electrostatic spinning technology has become a hot research topic.…”