Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting

Li, Binbin; Li, Qinghua; Mo, Jingxin; Dai, Hongyue

doi:10.3389/fphar.2017.00051

Cited by 62 publications

(58 citation statements)

References 111 publications

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“…In this regard, nanotechnology finds a major application [24]. Polymeric nanoparticles have been widely studied for tumor-targeted drug delivery [25,26]. Furthermore, lipid-based nanoparticles have demonstrated peculiar advantages such as prolonged circulation [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

et al. 2020

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Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for their potential in drug delivery of cytotoxic agents. Thus, the purpose of this study was to determine the potential enhancement of ICA cytotoxicity activity in OVCAR-3 ovarian cancer cells via its formulation in phytosomes. ICA-phytosomal formulation was optimized using a Box–Behnken design. Particle size, shape, and in vitro drug release were used to characterize the optimized formula. The optimized formulation exhibited enhanced in vitro drug release. ICA-phytosomes exhibited enhanced cytotoxicity against ovarian cancer cells. Cell cycle analysis indicated accumulation of cells challenged with ICA-phytosomes in G2/M and pre-G1 phases. Staining of cells with annexin V indicated significant elevation of percentage cells with early and late apoptosis as well as total cell death. In addition, the formulation significantly disturbed mitochondrial membrane potential and cellular content of caspase 3. In addition, intracellular release of reactive oxygen species (ROS) was enhanced by ICA-phytosomes. In conclusion, phytosome formulation of ICA significantly potentiates its cytotoxic activities against OVCAR-3 cells. This is mediated, at least partly, by enhanced ICA cellular permeation, apoptosis, and ROS.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

et al. 2020

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“…These features allow the extended use of nanoparticulates for cancer targeting and controlled release purposes. Many parenteral, oral, and topical nanoparticulate therapeutics are available on the market and clinical trial stages [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

Alshweiat

Ambrus

Csóka

2019

CMC

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There is always a need for alternative and efficient methods of drug delivery. The nasal cavity can be considered as a non-invasive and efficient route of administration. It has been used for local, systemic, brain targeting, and vaccination delivery. Although many intranasal products are currently available on the market, the majority is used for local delivery with fewer products available for the other targets. As nanotechnology utilization in drug delivery has rapidly spread out, the nasal delivery has become attractive as a promising approach. Nanoparticulate systems facilitate drug transportation across the mucosal barrier, protect the drug from nasal enzyme degradation, enhance the delivery of vaccines to the lymphoid tissue of the nasal cavity with an adjuvant activity, and offer a way for peptide delivery into the brain and the systemic circulation, in addition to their potential for brain tumor treatment. This review article aims at discussing the potential benefit of the intranasal nanoparticulate systems, including nanosuspensions, lipid and surfactant, and polymer-based nanoparticles as regards productive intranasal delivery. The aim of this review is to focus on the topicalities of nanotechnology applications for intranasal delivery of local, systemic, brain, and vaccination purposes during the last decade, referring to the factors affecting delivery, regulatory aspects, and patient expectations. This review further identifies the benefits of applying the Quality by Design approaches (QbD) in product development. According to the reported studies on nanotechnology-based intranasal delivery, potential attention has been focused on brain targeting and vaccine delivery with promising outcomes. Despite the significant research effort in this field, nanoparticle-based products for intranasal delivery are not available. Thus, further efforts are required to promote the introduction of intranasal nanoparticulate products that can meet the requirements of regulatory affairs with high patient acceptance.

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“…In the previous studies, it was stated that the drug-loaded nanoparticles can be larger in size compared to the empty nanoparticles (28,29). It was found that, particularly in cancer research, carrier systems smaller than 500 nm are more successful in delivering the drugs to the target tissues, therefore enabling active transport (30). On the other hand, it is known that nanoparticles larger than 200 nm are more effective in targeting macrophages that are used as host cells by the parasites, and that the nanoparticles of this size are phagocytosed by the macrophages (31).…”

Section: Discussionmentioning

confidence: 99%

A New Approach To The Treatment of Leıshmaniasis: Quercetin-Loaded Polycaprolactone Nanoparticles

Abamor

2018

Journal of the Turkish Chemical Society Section A: Chemistry

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Antileishmanial drugs used in the treatment of leishmaniasis are toxic and expensive. Moreover, parasites have recently developed resistance against them. Hence there is an increasing need for developing new antileishmanial medicines. Quercetin, found in the roots, leaves and fruits of many plants, is a natural polyphenolic flavonoid. Quercetin has antibacterial, antiviral, anti-carcinogenic, and antioxidant properties. On the other hand, because of its weak solubility in water, quercetin has had limited use on humans. To increase its bio-availability and maximize its therapeutic effects, quercetin has recently been encapsulated with nanoparticulate carrier systems. The aim of this study is to encapsulate quercetin in biodegradable, bio-compatible poly-ε-caprolactone (PCL) nanoparticles, to characterize the synthesized nanoparticles and to analyze their in vitro antileishmanial efficacy on L.infantum parasites. Quercetinloaded PCL nanoparticles (QPNPs) were synthesized using oil-in-water single emulsion solvent evaporation method. Their characterization was done using scanning electron microscopy (SEM) and dynamic light scattering (DLS) equipments. Encapsulation effectiveness and release profiles of QPNPs are calculated with UV-Vis spectrophotometry. The antileishmanial effectiveness of the synthesized nanoparticles was analyzed in L.infantum promastigote culture and amastigote-macrophage culture. The results indicated that QPNPs had an average size of 380 nm, a zeta potential of -6.56 mV, and a PDI value of 0.21. The measurements showed the quercetin-loaded nanoparticles to have an encapsulation effectiveness of 64% and a reaction efficiency of 55%. After an incubation of 192 hours, nanoparticles were seen to release 58% of their quercetin content. The synthesized QPNPs had IC50 values on L.infantum promastigotes and amastigotes of 86 and 144 µg/mL respectively. This means that QPNPs have reduced the vitality of promastigotes about 20 times and of amastigotes about 5 times as compared to the control group. These results demonstrate the strong antileishmanial potentials of QPNPs. It is believed that if these positive findings are supported by further in vivo studies, QPNPs may be used in the treatment of leishmaniasis.

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Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting

Cited by 62 publications

References 111 publications

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

A New Approach To The Treatment of Leıshmaniasis: Quercetin-Loaded Polycaprolactone Nanoparticles

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