Drug‐loading three‐dimensional scaffolds based on hydroxyapatite‐sodium alginate for bone regeneration

Liang, Tingting; Li, Fuyao; Huang, Zhu; Pi, Yixing; Miao, Guohou; Ren, Wen; Liu, Tiantao; Jiang, Qianzhou; Guo, Lvhua

doi:10.1002/jbm.a.37018

Cited by 41 publications

(26 citation statements)

References 49 publications

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“…In the presence of proteolytic enzymes, EGF is cleaved from the polypeptide and is progressively released from the scaffold. A constant and stable release over 3 weeks from an Alg/sodium hydroxyapatite hydrogel was observed for calcitonin-gene related peptide and naringin [171], while similar results were reported for the release of berberine from an Alg/calcium phosphate scaffold [172].…”

Section: Alginatesupporting

confidence: 80%

Polysaccharide 3D Printing for Drug Delivery Applications

et al. 2022

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3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well as in the large choice of materials. It is a powerful tool in the field of personalized pharmaceutical treatment, particularly crucial for pediatric and geriatric patients. Polysaccharides are abundant and inexpensive natural polymers, that are already widely used in the food industry and as excipients in pharmaceutical and cosmetic formulations. Due to their intrinsic properties, such as biocompatibility, biodegradability, non-immunogenicity, etc., polysaccharides are largely investigated as matrices for drug delivery. Although an increasing number of interesting reviews on additive manufacturing and drug delivery are being published, there is a gap concerning the printing of polysaccharides. In this article, we will review recent advances in the 3D printing of polysaccharides focused on drug delivery applications. Among the large family of polysaccharides, the present review will particularly focus on cellulose and cellulose derivatives, chitosan and sodium alginate, printed by fused deposition modeling and extrusion-based printing.

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Section: Alginatesupporting

confidence: 80%

Polysaccharide 3D Printing for Drug Delivery Applications

et al. 2022

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“…Recent studies reported the effective use of SA/HA-based scaffolds as biomedical materials, in which they identified their possibility of use in bone defect repair [ 9 ], bone regeneration [ 31 ], and promotion of new cartilage generation [ 32 ]. As mentioned above, our study involved enhanced mechanical properties compared with others.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications

et al. 2021

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In recent years, researchers working in biomedical science and technology have investigated alternatives for enhancing the mechanical properties of biomedical materials. In this work, sodium alginate (SA) hydrogel-reinforced nanoparticles (NPs) of hydroxyapatite (HA) were prepared to enhance the mechanical properties of this polymer. Compression tests showed an increase of 354.54% in ultimate compressive strength (UCS), and 154.36% in Young’s modulus with the addition of these NPs compared with pure SA. Thermogravimetric analysis (TGA) revealed that the amount of residual water is not negligible and covered a range from 20 to 35 wt%, and the decomposition degree of the alginate depends on the hydroxyapatite content, possibly due to the displacement of sodium ions by the hydroxyapatite and not by calcium chloride. Further, there is an important effect possibly due to the existence of an interaction of hydrogen bonds between the hydroxyl of the alginate and the oxygen atoms of the hydroxyapatite, so signals appear upfield in nuclear magnetic resonance (NMR) data. An increase in the accumulation of HA particles was observed with the use of X-ray microtomography, in which the quantified volume of particles per reconstructed volume corresponded accordingly to the increase in the mechanical properties of the hydrogel.

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“…For this reason, neuropeptides and axonal guidance molecules that possess osteogenic effects have been incorporated into bone scaffolds to promote tissue regeneration. For example, CGRP was used as printing ink in the fabrication of scaffolds and displayed osteoinductive abilities in vivo [ 14 ]. However, incorporation of proteins into scaffolds creates problems such as short half-lives, high cost, rapid degradation, difficulty in disinfection and immunogenicity.…”

Section: Introductionmentioning

confidence: 99%

Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration

Jiao

Wan

et al. 2022

Bioactive Materials

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Sensory nerves promote osteogenesis through the release of neuropeptides. However, the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain elusive. The present study identified that new bone formation was more abundantly produced after implantation of silicified collagen scaffolds into defects created in the distal femur of rats. The wound sites were accompanied by extensive nerve innervation and angiogenesis. Sensory nerve dysfunction by capsaicin injection resulted in significant inhibition of silicon-induced osteogenesis in the aforementioned rodent model. Application of extracellular silicon in vitro induced axon outgrowth and increased expression of semaphorin 3 A (Sema3A) and semaphorin 4D (Sema4D) in the dorsal root ganglion (DRG), as detected by the upregulation of signaling molecules. Culture medium derived from silicon-stimulated DRG cells promoted proliferation and differentiation of bone marrow mesenchymal stem cells and endothelial progenitor cells. These effects were inhibited by the use of Sema3A neutralizing antibodies but not by Sema4D neutralizing antibodies. Knockdown of Sema3A in DRG blocked silicon-induced osteogenesis and angiogenesis almost completely in a femoral defect rat model, whereas overexpression of Sema3A promoted the silicon-induced phenomena. Activation of “mechanistic target of rapamycin” (mTOR) pathway and increase of Sema3A production were identified in the DRG of rats that were implanted with silicified collagen scaffolds. These findings support the role of silicon in inducing Sema3A production by sensory nerves, which, in turn, stimulates osteogenesis and angiogenesis. Taken together, silicon has therapeutic potential in orthopedic rehabilitation.

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Drug‐loading three‐dimensional scaffolds based on hydroxyapatite‐sodium alginate for bone regeneration

Cited by 41 publications

References 49 publications

Polysaccharide 3D Printing for Drug Delivery Applications

Polysaccharide 3D Printing for Drug Delivery Applications

Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications

Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration

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