Drug metabolism in extrahepatic diseases

Farrell, Geoffrey C.

doi:10.1016/0163-7258(87)90101-x

Cited by 37 publications

(9 citation statements)

References 190 publications

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“…Mean ERMBT results were not different between HIV-positive and HIV-negative subjects, consistent with findings from a report that used midazolam clearance as a probe for CYP3A4 activity in HIV-positive patients compared with controls. 35 Some acute viral illnesses are well known to suppress the activity of CYP enzymes, 20,22,36 but the effects of HIV infection on CYP3A4 activity in humans have not been well studied. Investigation in a murine model reported reduced hepatic activity of CYP1A2 and CYP2E1 at 16 weeks in mice infected with the retrovirus LP-BM5 murine leukemia virus.…”

Section: Variability In Ermbt For Hiv-infected Patientsmentioning

confidence: 99%

Variability in Activity of Hepatic CYP3A4 in Patients Infected with HIV

Slain¹,

Pakyz

Israel³

et al. 2000

Pharmacotherapy

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Section: Variability In Ermbt For Hiv-infected Patientsmentioning

confidence: 99%

Variability in Activity of Hepatic CYP3A4 in Patients Infected with HIV

Slain¹,

Pakyz

Israel³

et al. 2000

Pharmacotherapy

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“…Although both patients had an acute bacterial in fection, there is no evidence that it could produce disturb ances in the metabolic hepatic capacity, except when there are complications (septic shock, congestive heart failure or hepatic failure) [9], but our patients did not have these problems.…”

Section: Alvarez/del Castillo/ortizmentioning

confidence: 79%

Interaction between Ciclosporin and Ceftriaxone

Álvarez¹,

Castillo²,

Ortiz

1991

Nephron

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“…It is important that clinical protocols for drug administration are established based on pharmacokinetic studies conducted in healthy volunteers. Moreover, drug metabolism is substantially suppressed during the APR due to a decrease in hepatic cytochrome P-450 content and related enzyme activities [37]. Thus, a decrease in the binding of anionic drugs in plasma during the APR should enhance their tissue uptake.…”

Section: Discussionmentioning

confidence: 99%

Untitled

et al. 2002

Clin Exp Med

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The acute-phase response alters the composition of carrier proteins in plasma, which may affect the blood deposition and transport of biomediators and drugs. The effect of the acute-phase response on the ligand binding ability of plasma was studied in leukemic children with and without systemic inflammation (sepsis and septic shock). To target different transport proteins, differentially charged fluorescent dyes were used: anionic ANS (8-anilinonaphthalene-1-sulfonate), uncharged Nile red, and cationic Quinaldine red. Human serum albumin was a principal carrier for ANS and competed for Nile red binding with lipoproteins. The synchro-scan fluorescence spectra of Nile red in plasma distinguished two species of the dye bound to serum albumin and to low-density and/or very low-density lipoproteins. The binding of Quinaldine red did not correlate with albumin and lipoprotein levels, and was probably determined by alpha(1)-acid glycoprotein. Compared with the control group, leukemia increased Quinaldine red binding by 65% and did not significantly affect the binding of other probes. Sepsis and septic shock did not change the binding of Quinaldine red, but progressively decreased ANS binding, finally by about 33%, and shifted Nile red distribution from serum albumin toward lipoproteins. These changes reflected a modified composition of the three principal transport proteins in plasma in the acute-phase response. Simple and rapid fluorescent tests developed in this study can be used to evaluate the acute-phase response and to optimize drug administration protocols in clinical practice.

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Drug metabolism in extrahepatic diseases

Cited by 37 publications

References 190 publications

Variability in Activity of Hepatic CYP3A4 in Patients Infected with HIV

Variability in Activity of Hepatic CYP3A4 in Patients Infected with HIV

Interaction between Ciclosporin and Ceftriaxone

Untitled

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