Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice

Matoušková, Petra; Bártíková, Hana; Boušová, Iva; Levorová, Lucie; Szotáková, Barbora; Skálová, Lenka

doi:10.1124/dmd.114.061176

Cited by 14 publications

(4 citation statements)

References 69 publications

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“…Nrf2, one of the redox-associated transcription factors, is a crucial molecule that regulates antioxidant defense system-related enzymes, such as SODs, HO-1, NQO1, and GPx. , Hence, Nrf2 is regarded as a potential target in the prevention and amelioration of obesity and obesity-derived oxidative stress. In previous reports, the antioxidant defense system was shown to be damaged under obese condition. − Our results similarly showed that renal Nrf2 and its related proteins were significantly increased in an obese group. In contrast to protein levels of antioxidant enzymes including MnSOD, total SOD activity in the obesity group was lower than that of the normal group.…”

Section: Discussionsupporting

confidence: 84%

Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice

Park

Jeon

et al. 2017

J. Agric. Food Chem.

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Immoderate fat accumulation causes both oxidative stress and inflammation, which can induce kidney damage in obesity. Previously, Ecklonia cava has shown anti-inflammatory and antioxidative effects. Our group aimed to investigate whether E. cava polyphenol extract (ECPE) improves renal damage in high fat diet (HFD)-induced obese mice through regulation of not only energy metabolism but also oxidative stress and inflammation. After obesity induction by HFD, the mice were treated with different dosages of ECPE (100 or 500 mg/kg/day) by gavage for 12 weeks. ECPE treatment lowered the protein levels related to lipid accumulation (SREBP1c, ACC& FAS), inflammation (NLRP3 inflammasome, NFκB, MCP-1, TNF-α & CRP), and oxidative stress (Nrf2, HO-1, MnSOD, NQO1, GPx, 4-HNE and protein carbonyls) in HFD induced obese mice. Moreover, ECPE supplementation significantly up-regulated renal SIRT1, PGC-1α, and AMPK, which are associated with renal energy metabolism. Consequently, the results provide novel insights into the anti-inflammatory roles of ECPE in obesity-induced renal inflammation.

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Section: Discussionsupporting

confidence: 84%

Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice

Park

Jeon

et al. 2017

J. Agric. Food Chem.

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“…Elevated activities of drug‐metabolizing enzymes, NAD(P)H:quinone oxidoreductase 1 and UDP‐glucuronosyltransferases 1A, caused alterations in drug pharmacokinetics, in an MSG‐mouse model of obesity (4 mg/g/day, s.c., MSG to newborn mice, in the first 6 days of life, followed by 10 mg/g day in days 7 and 8, and 20 mg/g in days 9 and 10). Moreover, decreased capacity of glutathione S‐transferases, in obese animals, indicated a potentially reduced antioxidant defense and diminished chemoprotection (Dluzen & Lazarus, ; Matouskova et al., ). These enzymes can either inactivate carcinogens or, in some cases, generate reactive species with higher reactivity compared to the original compound.…”

Section: Promotion Of Tumor Development In Msg‐induced Obesitymentioning

confidence: 99%

A Review of the Alleged Health Hazards of Monosodium Glutamate

Zanfirescu

Ungurianu

Tsatsakis

et al. 2019

Comp Rev Food Sci Food Safe

180

118

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Monosodium glutamate (MSG) is an umami substance widely used as flavor enhancer. Although it is generally recognized as being safe by food safety regulatory agencies, several studies have questioned its long‐term safety. The purpose of this review was to survey the available literature on preclinical studies and clinical trials regarding the alleged adverse effects of MSG. Here, we aim to provide a comprehensive overview of the reported possible risks that may potentially arise following chronic exposure. Preclinical studies have associated MSG administration with cardiotoxicity, hepatotoxicity, neurotoxicity, low‐grade inflammation, metabolic disarray, and premalignant alterations, along with behavioral changes. However, in reviewing the available literature, we detected several methodological flaws, which led us to conclude that these studies have limited relevance for extrapolation to dietary human intake of MSG risk exposure. Clinical trials have focused mainly on MSG effects on food intake and energy expenditure. Besides its well‐known impact on food palatability, MSG enhances salivary secretion and interferes with carbohydrate metabolism, while the impact on satiety and post‐meal recovery of hunger varied in relation to meal composition. Reports on MSG hypersensitivity or links of its use to increased pain sensitivity and atopic dermatitis were found to have little supporting evidence. Many of the reported negative health effects of MSG have little relevance for chronic human exposure and are poorly informative as they are based on excessive dosing that does not meet with levels normally consumed in food products. We conclude that further clinical and epidemiological studies are needed, with an appropriate design, accounting for both added and naturally occurring dietary MSG.

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“…Our in vivo study with non-obese mice, but the same experimental design as in the presented one, showed a different effect of GTE on the activity of NQO (increase), GPx and GST (decrease) . Moreover, this dissimilarity can be connected with the fact that obesity itself altered the activity of these enzymes in comparison to the non-obese rodents [Noeman et al, 2011;Matouskova et al, 2015], which may be caused by elevated expression of Nrf2 in MSG-obese mice . Moreover, the effect of green tea polyphenols on the antioxidant system of rodents is concentration-dependent with high doses (5-10 g/kg of the diet) causing down-regulation of Nrf2-dependent antioxidant enzymes in the liver and kidney [Murakami, 2014].…”

Section: Discussionmentioning

confidence: 99%

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Bártíková¹,

Boušová²,

Matoušková³

et al. 2017

Pol. J. Food Nutr. Sci.

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Key words: monosodium glutamate-induced obesity, catechins, oxidative stress, polyphenon 60Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their effi cacy in obese individuals is insuffi cient. The present study was designed to follow up the effect of defi ned and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specifi c activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specifi c activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.Unauthenticated Download Date | 5/12/18 3:35 AM

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Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice

Cited by 14 publications

References 69 publications

Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice

Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice

A Review of the Alleged Health Hazards of Monosodium Glutamate

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

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