Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives

Abstract

Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or anticancer drugs for nanoparticle formulations such as micelles, microemulsions, and liposomes. ASC-P vesicles called aspasomes are submicron-sized particles that can encapsulate hydrophilic drugs. Several transdermal and injectable formulations of ascorbyl n-alkyl fatty acid derivatives were used, including ascorbyl palmitate.

Kinetics and Mechanism of Oxidation of L-Ascorbic Acid by Pt(IV)(aq) in Aqueous Hydrochloric Acid Medium

“…We arrive at the reaction shown in ( The second-order rate constant (k) for reduction of Pt(IV) was calculated using (4) 4.39 Jk mol −1 (see Table 2). They are close to the reported value for similar systems [18,19,23]. The value of activation parameters is favorable for electron transfer reaction.…”

“…L-ascorbic acid (H 2 ASc) has two acidic protons (pK 1 = 4.04 and pK 2 = 11.34) [18] and is a strong reducing agent (E 0 = 0.390 V NHE) in aqueous solutions. The electron transfer reaction between PtCl 6 2− and L-ascorbic acid was investigated by changing (L-ascorbic acid) in the range 0.05 to 0.3 mol dm −3 at [H + ] = 0.14 mol dm −3 and I = 0.5 mol dm −3 .…”

Untitled

“…So excipient play major role with their contribution in above factors. Drug nanoparticle formulation using ascorbic acid derivatives (ascorbyl glycoside) used not only as antioxidant but also as carrier compound 37 .…”

Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery

“…The antioxidant potency of aspasome was much better than that of ascorbic acid [161, 162]. Thus, it can find applications as drug delivery system in disorders implicated with reactive oxygen species.…”