Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery

Abstract

Lipid-based innovations have achieved new heights during the last few years as an essential component of drug development. The current challenge of drug delivery is liberation of drug agents at the right time in a safe and reproducible manner to a specific target site. A number of novel drug delivery systems has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Microparticulate lipoidal vesicular system represents a unique technology platform suitable for the oral and systemic administration of a wide variety of molecules with important therapeutic biological activities, including drugs, genes, and vaccine antigens. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. Also, novel lipid carrier-mediated vesicular systems are originated. This paper has focused on the lipid-based supramolecular vesicular carriers that are used in various drug delivery and drug targeting systems.

Proniosomal Oral Tablets for Controlled Delivery and Enhanced Pharmacokinetic Properties of Acemetacin

“…Niosomal technology is believed to improve drug solubility, enhance drug permeability by their adhesive and surface-active properties, and protect the drug against gastrointestinal enzymatic degradation probabilities (4). Unlike liposomes, niosomal vesicles can survive the gastrointestinal acidic, bile, and enzymatic conditions (5). However, niosomal dispersion also suffers physical instability such as vesicle aggregations, fusion, size changes, and drug leaks to the outside buffer medium.…”

An Overview Of: Vesicular Drug Delivery System

“…[8,9] www.wjpps.com The targeted vesicles are classified on the basis of their composition. [16] a. Lipoidal biocarriers [17] Liposomes were first described by British haematologist Dr Alec D Bangham FRS in 1961…”

“…Emulsomes is a lipid based drug delivery system, especially designed for parenteral delivery of drugs having poor aqueous solubility [40] Nanosize Lipid particles (bio adhesives nanoemulsion) consisted of microscopic lipid assembly with a polar core [39] in emulsomes, the internal core is made up of fats and triglycerides, which are stabilize in form of o/w emulsion by addition of high concentration of lecithin. Emulsomes have the characteristics of both liposomes and emulsions.…”

“…The solvent-free and surfactant-free emulsomes technologies have demonstrated high encapsulation capacity for water insoluble antifungal and anticancer drugs, showed enhanced drug delivery and improved preclinical efficacy for oral route. [40] This study focus on …”

HIV Vaccines: A Brief Overview

“…Viral‐like particles (VLPs) are structures, manufactured in vitro , combine a non‐replicating, non‐pathogenic viral vector with the desired antigen. They retain the vector's cell binding ability, which results in antigen presentation via MHC class I and II . Recent attempts with VLP‐based vaccines have been largely disappointing.…”